Maternal exposure to traffic-related ambient particles and risk of gestational diabetes mellitus with isolated fasting hyperglycaemia: A retrospective cohort study in Beijing, China

Zou, Xiaoxuan; Fang, Jugao; Yang, Ying; Wu, Ruihong; Wang, Shuo; Xu, Hongbing; Jia, Jiajing; Yang, Huajun; Yuan, Ningman; Hu, Meina; Zhao, Yanqing; Xie, Yunfei; Zhu, Yu; Wang, Tong; Deng, Yuzhi; Song, Xiaoming; Ma, Xu; Huang, Wei

doi:10.1016/j.ijheh.2022.113973

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…32 Our study further confirmed this association in pregnant women, aligning with several recent studies in China. 12,33,34 For example, a birth cohort study conducted in Foshan 34 concluded that a 10 μg/m 3 increase in PM 2.5 during the first two trimesters (mean level: 38.2 μg/m 3 ) was associated with a 0.18 mmol/L increase in FPG. Another cohort study in Guangzhou and Heshan also identified that PM 2.5 (mean level: about 39 μg/m 3 ) was associated with isolated fasting hyperglycemia but not OGTT 1 h or 2 h glucose levels during pregnancy.…”

Section: ■ Discussionmentioning

confidence: 99%

Gestational and Postpartum Exposure to PM_2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study

Chen,

Wang,

Chen

et al. 2024

Environ. Sci. Technol.

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Pregnant women are physiologically prone to glucose intolerance, while the puerperium represents a critical phase for recovery. However, how air pollution disrupts glucose homeostasis during the gestational and early postpartum periods remains unclear. This prospective cohort study conducted an oral glucose tolerance test and measured the insulin levels of 834 pregnant women in Guangzhou, with a follow-up for 443 puerperae at 6−8 weeks postpartum. Residential PM 2.5 and five chemical components were estimated by an established spatiotemporal model. The adjusted linear model showed that an IQR increase in gestational PM 2.5 exposure was associated with an increase of 0.17 mmol/L (95% CI: 0.06, 0.28) in fasting plasma glucose (FPG) and 0.24 (95% CI: 0.05, 0.42) in the insulin resistance index. Postpartum PM 2.5 exposure was linked to a 0.17 mmol/L (95% CI: 0.05, 0.28) elevation in FPG per IQR, with a strengthened association found in women with gestational diabetes (P interaction = 0.003). In the quantile-based g-computation model, NO 3 − consistently contributed to the combined effect of PM 2.5 components on gestational and postpartum FPG. This study was the first to suggest that PM 2.5 components were associated with exacerbated gestational insulin resistance and elevated postpartum FPG. Targeted interventions reducing the emissions of toxic PM 2.5 components are essential to improving maternal glucose metabolism.

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Section: ■ Discussionmentioning

confidence: 99%

Gestational and Postpartum Exposure to PM_2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study

Chen,

Wang,

Chen

et al. 2024

Environ. Sci. Technol.

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“…In the present study, we identified that protein powder supplementation mainly affected GDM subtypes with abnormal fasting glucose, which was consistent with the relationship between other exposures and GDM subtypes. 32,33 Some recent studies have indicated that individuals with isolated impaired fasting glucose and isolated impaired glucose tolerance have different insulin sensitivity characteristics of the liver and muscle. 34,35 Individuals with isolated impaired fasting glucose primarily manifest hepatic insulin resistance and relatively normal muscle insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Protein powder supplementation in early pregnancy and the risk of gestational diabetes mellitus: a prospective cohort study

et al. 2023

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“…ORs with 95% CIs were reported for per IQR increases in NO 2 , O 3 , PM 10 , PM 2.5 , SO 2 , and CO concentrations during each exposure window. We also established a two-pollutant model to evaluate whether the risk of GDM from the studied pollutants changed after controlling for other pollutants unless the Spearman’s correlation coefficient of the two pollutants was greater than 0.6 [ 40 ]. We performed stratified analyses according to the OGTT sampling time (cold and warm seasons), age (<35 and ≥35 years old), and BMI (<24 and ≥24 kg/cm 2 ).…”

Section: Methodsmentioning

confidence: 99%

The Influence of Airborne Particulate Matter on the Risk of Gestational Diabetes Mellitus: A Large Retrospective Study in Chongqing, China

Zeng,

Zhan,

Zhou

et al. 2023

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Emerging research findings suggest that airborne particulate matter might be a risk factor for gestational diabetes mellitus (GDM). However, the concentration–response relationships and the susceptible time windows for different types of particulate matter may vary. In this retrospective analysis, we employ a novel robust approach to assess the crucial time windows regarding the prevalence of GDM and to distinguish the susceptibility of three GDM subtypes to air pollution exposure. This study included 16,303 pregnant women who received routine antenatal care in 2018–2021 at the Maternal and Child Health Hospital in Chongqing, China. In total, 2482 women (15.2%) were diagnosed with GDM. We assessed the individual daily average exposure to air pollution, including PM2.5, PM10, O3, NO2, SO2, and CO based on the volunteers’ addresses. We used high-accuracy gridded air pollution data generated by machine learning models to assess particulate matter per maternal exposure levels. We further analyzed the association of pre-pregnancy, early, and mid-pregnancy exposure to environmental pollutants using a generalized additive model (GAM) and distributed lag nonlinear models (DLNMs) to analyze the association between exposure at specific gestational weeks and the risk of GDM. We observed that, during the first trimester, per IQR increases for PM10 and PM2.5 exposure were associated with increased GDM risk (PM10: OR = 1.19, 95%CI: 1.07~1.33; PM2.5: OR = 1.32, 95%CI: 1.15~1.50) and isolated post-load hyperglycemia (GDM-IPH) risk (PM10: OR = 1.23, 95%CI: 1.09~1.39; PM2.5: OR = 1.38, 95%CI: 1.18~1.61). Second-trimester O3 exposure was positively correlated with the associated risk of GDM, while pre-pregnancy and first-trimester exposure was negatively associated with the risk of GDM-IPH. Exposure to SO2 in the second trimester was negatively associated with the risk of GDM-IPH. However, there were no observed associations between NO2 and CO exposure and the risk of GDM and its subgroups. Our results suggest that maternal exposure to particulate matter during early pregnancy and exposure to O3 in the second trimester might increase the risk of GDM, and GDM-IPH is the susceptible GDM subtype to airborne particulate matter exposure.

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Maternal exposure to traffic-related ambient particles and risk of gestational diabetes mellitus with isolated fasting hyperglycaemia: A retrospective cohort study in Beijing, China

Cited by 5 publications

References 38 publications

Gestational and Postpartum Exposure to PM_2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study

Gestational and Postpartum Exposure to PM_2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study

Protein powder supplementation in early pregnancy and the risk of gestational diabetes mellitus: a prospective cohort study

The Influence of Airborne Particulate Matter on the Risk of Gestational Diabetes Mellitus: A Large Retrospective Study in Chongqing, China

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Maternal exposure to traffic-related ambient particles and risk of gestational diabetes mellitus with isolated fasting hyperglycaemia: A retrospective cohort study in Beijing, China

Cited by 5 publications

References 38 publications

Gestational and Postpartum Exposure to PM2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study

Gestational and Postpartum Exposure to PM2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study

Protein powder supplementation in early pregnancy and the risk of gestational diabetes mellitus: a prospective cohort study

The Influence of Airborne Particulate Matter on the Risk of Gestational Diabetes Mellitus: A Large Retrospective Study in Chongqing, China

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Gestational and Postpartum Exposure to PM_2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study

Gestational and Postpartum Exposure to PM_2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study