Maternal exposure to sulfur dioxide and the risk of oral clefts in Liaoning Province, China: a population-based case-control study

Liu, Fang-Hua; Xing, Ze; Gong, Ting-Ting; Zhang, Jiayu; Huang, Yan-Hong; Li, Jing; Liu, Shu; Chen, Yanling; Li, Lili; Jiang, Cheng-Zhi; Chen, Zong-Jiao; Zhao, Yang; Yang, Hui-Juan

doi:10.1007/s11356-021-13461-0

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…The results of a case-control study in Liaoning Province of China showed that exposure to SO2 increased the incidence of cleft lip and/or cleft palate in the first three months of pregnancy and the first month of pregnancy. The cOR = 1.63,95% CI = (1.38,1.93) of cleft lip and (or) cleft palate in the first month of pregnancy was the same as our results (29). A case-control study in Texas, the United States, showed that PM 2.5 and SO 2 increased the incidence of congenital heart disease during the third to eighth weeks of pregnancy, which is the same as our findings in the second month of pregnancy (30).…”

Section: Discussionsupporting

confidence: 89%

Association between air pollutants and birth defects in Xiamen, China

Huang

Qiu

et al. 2023

Front. Pediatr.

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ObjectiveTo explore the relationship between common air pollution and common birth defects, and to provide reference for the prevention of birth defects.MethodsWe conducted a case-control study in Xiamen, a city in southeastern China from 2019 to 2020. Logistics regression was used to analyze the relationship between sulfur dioxide(SO2), fine particulate matter 2.5(PM2.5), nitrogen dioxide(NO2), ozone(O3), carbon monoxide(CO) and the occurrence of common birth defects such as congenital heart disease, facial cleft, and finger deformity.ResultsSO2 significantly increased the risk of birth defects such as congenital heart disease, cleft lip and/or cleft palate, and ear deformity in the first and second months of pregnancy.ConclusionExposure to common air pollutants increases the risk of birth defects, and SO2 significantly affects the occurrence of birth defects in the first two months of pregnancy.

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Section: Discussionsupporting

confidence: 89%

Association between air pollutants and birth defects in Xiamen, China

Huang

Qiu

et al. 2023

Front. Pediatr.

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“…Fourthly, different studies have different exposure assessment methods. Marshall EG et al, Hansen CA et al and Liu FH et al used air quality monitoring stations to monitor the exposure assigned by individuals within a speci ed radius around, which may lead to measurement errors in exposure concentration, which may cause errors in risk assessment and result deviations [25,26,30]. Finally, the exposure points of the literature we included all selected the pregnancy address, without considering the possibility of mobility during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…After full-text reading, 53 articles that did not meet the requirements were excluded, including 22 articles on animal experiments, 28 articles on reviews, conferences, and case reports, and 3 articles on lack of data evaluation. Finally, 11 articles were included in the study [22][23][24][25][26][27][28][29][30][31][32]( Fig. 1).…”

Section: Literature Selectionmentioning

confidence: 99%

Association between gestational exposure and risk of orofacial Clefts: A systematic review and meta-analysis

Huang

Qiu

et al. 2023

Preprint

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Background: The occurrence of orofacial Clefts (OFCs) is a congenital disease caused by many factors. According to recent studies, air pollution has a strong correlation with the occurrence of OFCs. However, there are still some controversies about the current research results, and there is no relevant research to review the latest results in recent years. Objective: In this paper, the authors conducted a systematic review and meta-analysis to explore the correlation between ambient air pollution and the occurrence of neonatal OFCs deformity. Methods: We searched Pubmed, Web of science, and Embase databases from the establishment of the database to May 2023. We included observational studies on the relationship between prenatal exposure to fine particulate matter 2.5 (PM2.5), fine particulate matter 10 (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), carbon monoxide (CO) and the risk of cleft lip (CL), cleft palate (CP), cleft lip with or without palate (CL/P). the Newcastle-Ottawa quality assessment scale (NOS) was used to evaluate the quality of the literature. Funnel plot and Egger's regression were used to verify the publication bias. Random effect model or fixed effect model was used to estimate the combined relative risk (RR) and 95% confidence interval (95%CI). Results: A total of eleven studies were included in this study, including four cohort studies and seven case-control studies, including 22453 cases of OFCs. Ten studies had low risk of bias and only one study had high risk of bias. Three studies reported that PM2.5 was positively correlated with CL and CP, with a combined RR and 95%CI of 1.287(1.174,1.411) and 1.267 (1.105,1.454). Two studies reported a positive correlation between O3 and CL, with a combined RR and 95%CI of 1.132(1.047,1.225). Two studies reported a positive correlation between PM10 and CL, with a combined RR and 95%CI of 1.108 (1.017,1.206). No association was found between SO2, CO, NO2 exposure during pregnancy and the risk of OFCs. Conclusion: The results of this study showed that there was a significant statistical correlation between exposure to PM10, PM2.5, O3 and the risk of OFCs in the second month of pregnancy. Exposure assessment, research methods and mechanisms need to be further explored.

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“…Besides, Marshall et al in a study from New Jersey also provided evidence for the association between CL/P and SO 2 at the highest exposure level (aOR = 1.6, 95% CI 1.1, 2.2) [ 26 ]. However, another study performed by Liu et al in Liaoning, China reported no significant effects [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

First trimester exposure to ambient gaseous air pollutants and risk of orofacial clefts: a case–control study in Changsha, China

Jiang

Xie

et al. 2021

BMC Oral Health

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Background A growing body of studies have investigated the association between air pollution exposure during early pregnancy and the risk of orofacial clefts, but these studies put more emphasis on particulate matter and reported inconsistent results, while research on the independent effects of gaseous air pollutants on orofacial clefts has been quite inadequate, especially in China. Methods A case–control study was conducted in Changsha, China from 2015 to 2018. A total of 446 cases and 4460 controls were included in the study. Daily concentrations of CO, NO2, SO2, O3, PM2.5 and PM10 during the first trimester of pregnancy were assigned to each subject using the nearest monitoring station method. Multivariate logistic regression models were applied to evaluate the associations of monthly average exposure to gaseous air pollutants with orofacial clefts and its subtypes before and after adjusting for particulate matter. Variance inflation factors (VIFs) were used to determine if the effects of gaseous air pollutants could be independent of particulate matter. Results Increase in CO, NO2 and SO2 significantly increased the risk of cleft lip with or without cleft palate (CL/P) in all months during the first trimester of pregnancy, with aORs ranging from 1.39 to 1.48, from 1.35 to 1.61 and from 1.22 to 1.35, respectively. The risk of cleft palate only (CPO) increased with increasing NO2 exposure levels in the first trimester of pregnancy, with aORs ranging from 1.60 to 1.66. These effects sustained and even exacerbated after adjusting for particulate matter. No significant effect of O3 was observed. Conclusions Our study suggested that maternal exposure to CO, NO2, and SO2 during the first trimester of pregnancy might contribute to the development of orofacial clefts, and the associations were potentially independent of particulate matter.

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Maternal exposure to sulfur dioxide and the risk of oral clefts in Liaoning Province, China: a population-based case-control study

Cited by 7 publications

References 35 publications

Association between air pollutants and birth defects in Xiamen, China

Association between air pollutants and birth defects in Xiamen, China

Association between gestational exposure and risk of orofacial Clefts: A systematic review and meta-analysis

First trimester exposure to ambient gaseous air pollutants and risk of orofacial clefts: a case–control study in Changsha, China

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