Maternal exposure to PM2.5 induces cognitive impairment in offspring via cerebellar neuroinflammation and oxidative stress

Zhang, Jiajia; Yang, Yingying; Al-Ahmady, Zahraa S.; Du, Wenchong; Duan, Jinjin; Liao, Ziqi; Sun, Qinghua; Wei, Zhiyun; Hua, Jing

doi:10.1016/j.ecoenv.2022.114425

Cited by 2 publications

(1 citation statement)

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“…The potential long-term effects of air pollution on children’s neurodevelopment are not yet fully understood. In a previous study, our team demonstrated that exposure to PM2.5 during pregnancy can induce cognitive and motor impairment in offspring mice, primarily mediated by persistent brain damage of aseptic inflammatory response and cerebellar oxidative stress [ 97 ]. Furthermore, a parallel study provided additional insight into the underlying biological mechanism of PM2.5-induced brain impairment, which is mediated by an inflammatory reaction and regulated by DNA methylation [ 55 ].…”

Section: Advances In Epigenetics Of Dcd and Its Comorbiditymentioning

confidence: 99%

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

et al. 2023

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Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition’s aetiology.

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Section: Advances In Epigenetics Of Dcd and Its Comorbiditymentioning

confidence: 99%

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

et al. 2023

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Preterm Birth and Developmental Coordination Disorder: What Do We Know and Not Know?

Du,

Hua

2023

Curr Dev Disord Rep

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Purpose of Review Despite increasing research on the association between preterm birth and DCD, some critical questions remain unanswered. This review therefore aims to examine the current state of knowledge and identify areas that require further research. Recent Findings Recent findings indicate that preterm birth is associated with a greater risk of DCD, with increasing severity of impairment observed with decreasing gestational age before 40 weeks. Numerous studies have examined risk factors for preterm DCD, but few have investigated the mechanisms separately for preterm and term-born DCD, which makes it challenging to determine if they share similar etiological factors. Evidence suggests that the developmental trajectory between preterm and term-born DCD may differ, but more details is required. Additionally, research has also been limited by inconsistent definitions of preterm populations in terms of the degree of prematurity and the use of gestational age and/or birth weight. Summary Further research is needed to fully comprehend the association between preterm birth and DCD and to develop effective prevention and intervention strategies.

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Maternal exposure to PM2.5 induces cognitive impairment in offspring via cerebellar neuroinflammation and oxidative stress

Cited by 2 publications

References 53 publications

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

Preterm Birth and Developmental Coordination Disorder: What Do We Know and Not Know?

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