Maternal exposure to organophosphate flame retardants alters locomotor and anxiety-like behavior in male and female adult offspring

Wiersielis, Kimberly R.; Adams, Sherrill L.; Yasrebi, Ali; Conde, Kristie; Roepke, Troy A.

doi:10.1016/j.yhbeh.2020.104759

Cited by 32 publications

(27 citation statements)

References 47 publications

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“…Males, regardless of diet, appear to have a trending reduction in time spent in this zone, an anxiogenic effect. This is consistent with our previous work (Wiersielis et al, 2020), as we identified a male OPFR‐induced reduction in time spent in a small center zone on the OFT. Although we did detect trending and significant differences in anxiety‐like behavior in female mice, we can only cautiously make conclusions.…”

Section: Discussionsupporting

confidence: 94%

“…Similar to our previous findings (Wiersielis et al, 2020), we did not detect any significant alterations in OFT locomotion in males. In females, we have previously identified a reduction in locomotion from perinatal OPFR exposure in mice fed a standard chow diet (Wiersielis et al, 2020). Here, we observed a similar trend in mice fed LFD, which most closely resembles standard chow.…”

Section: Discussionsupporting

confidence: 92%

“…We have previously demonstrated sex‐specific alterations in locomotion and anxiety‐like behavior from maternal exposure to the same OPFR mixture, concentration, and exposure window (Wiersielis et al, 2020). Similar to our previous findings (Wiersielis et al, 2020), we did not detect any significant alterations in OFT locomotion in males. In females, we have previously identified a reduction in locomotion from perinatal OPFR exposure in mice fed a standard chow diet (Wiersielis et al, 2020).…”

Section: Discussionmentioning

confidence: 91%

“…A growing body of literature has detected alterations in behavior from the developmental exposure to OPFRs (Baldwin et al, 2017; Gillera et al, 2019; Patisaul et al, 2013; Wiersielis, Adams, Yasrebi, Conde, & Roepke, 2020). We have previously demonstrated sex‐specific alterations in locomotion and anxiety‐like behavior from maternal exposure to the same OPFR mixture, concentration, and exposure window (Wiersielis et al, 2020). Similar to our previous findings (Wiersielis et al, 2020), we did not detect any significant alterations in OFT locomotion in males.…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, we may be able to characterize these differences due to age of animal. Our previous work tested young adult mice (8 and 9 weeks) (Wiersielis et al, 2020), while here, mature adult mice (19 and 20 weeks) were evaluated. In females, we only detected the main effect of diet on open arm time and a trending effect of diet in the percentage of time spent in the open arms.…”

Section: Discussionmentioning

confidence: 99%

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Maternal organophosphate flame‐retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually‐dimorphic manner in mice

Walley

Krumm

Yasrebi

et al. 2020

J of Applied Toxicology

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Increased usage of organophosphate flame retardants (OPFRs) has led to detectable levels in pregnant women and neonates, which is associated with negative neurological outcomes. Therefore, we investigated if maternal OPFR exposure altered adult offspring feeding, locomotor, and anxiety‐like behaviors on a low‐fat (LFD) or high‐fat diet (HFD). Wild‐type C57Bl/6J dams were orally dosed with vehicle (sesame oil) or an OPFR mixture (1 mg/kg combination each of tris(1,3‐dichloro‐2‐propyl)phosphate, triphenyl phosphate and tricresyl phosphate) from gestation day 7 to postnatal day 14. After weaning, pups were fed either a LFD or HFD until 19 weeks of age. Locomotor and anxiety‐like behaviors were evaluated with the open field test, elevated plus maze, and metabolic cages. Feeding behaviors and meal patterns were analyzed by a Biological Data Acquisition System. Anogenital distance was reduced in OPFR‐exposed male pups, but no effect was detected on adult body weight. We observed interactions of OPFR exposure and HFD consumption on locomotor and anxiety‐like behavior in males, suggesting an anxiogenic effect while reducing overall nighttime activity. We also observed an interaction of OPFR exposure and HFD on weekly food intake and feeding behaviors. OPFR‐exposed males consumed more total HFD than oil‐exposed males during the 72‐hour trial. However, when arcuate gene expression was analyzed, OPFR exposure induced Agrp expression in females, which would suggest greater orexigenic tone. Collectively, the implications of our study are that the behavioral effects of OPFR exposure are modulated by adult HFD consumption, which may influence the metabolic and neurological consequences of maternal OPFR exposure.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Maternal organophosphate flame‐retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually‐dimorphic manner in mice

Walley

Krumm

Yasrebi

et al. 2020

J of Applied Toxicology

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Developmental exposure to the flame retardant, triphenyl phosphate, causes long‐lasting neurobehavioral and neurochemical dysfunction

Hawkey

Evans

Holloway

et al. 2022

Birth Defects Research

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Background Human exposures to organophosphate flame retardants result from their use as additives in numerous consumer products. These agents are replacements for brominated flame retardants but have not yet faced similar scrutiny for developmental neurotoxicity. We examined a representative organophosphate flame retardant, triphenyl phosphate (TPP) and its potential effects on behavioral development and dopaminergic function. Methods Female Sprague–Dawley rats were given low doses of TPP (16 or 32 mg kg−1 day−1) via subcutaneous osmotic minipumps, begun preconception and continued into the early postnatal period. Offspring were administered a battery of behavioral tests from adolescence into adulthood, and littermates were used to evaluate dopaminergic synaptic function. Results Offspring with TPP exposures showed increased latency to begin eating in the novelty‐suppressed feeding test, impaired object recognition memory, impaired choice accuracy in the visual signal detection test, and sex‐selective effects on locomotor activity in adolescence (males) but not adulthood. Male, but not female, offspring showed marked increases in dopamine utilization in the striatum, evidenced by an increase in the ratio of the primary dopamine metabolite (3,4‐dihydroxyphenylacetic acid) relative to dopamine levels. Conclusions These results indicate that TPP has adverse effects that are similar in some respects to those of organophosphate pesticides, which were restricted because of their developmental neurotoxicity.

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A single-cell survey unveils cellular heterogeneity and sensitive responses in mouse cortices induced by oral exposure to triphenyl phosphate

Zhu

et al. 2022

Arch Toxicol

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Maternal exposure to organophosphate flame retardants alters locomotor and anxiety-like behavior in male and female adult offspring

Cited by 32 publications

References 47 publications

Maternal organophosphate flame‐retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually‐dimorphic manner in mice

Maternal organophosphate flame‐retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually‐dimorphic manner in mice

Developmental exposure to the flame retardant, triphenyl phosphate, causes long‐lasting neurobehavioral and neurochemical dysfunction

A single-cell survey unveils cellular heterogeneity and sensitive responses in mouse cortices induced by oral exposure to triphenyl phosphate

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