Maternal exposure to O3 and NO2 may increase the risk of newborn congenital hypothyroidism: a national data-based analysis in China

Qi, Cuifang; Shang, Li; Yang, Wenfang; Huang, Liyan; Yang, Lei; Xin, Juan; Wang, Shanshan; Yue, Jie; Zeng, Lingxia; Chung, Mei

doi:10.1007/s11356-021-13083-6

Cited by 7 publications

(5 citation statements)

References 49 publications

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“…Although traditionally exposure to environmental air pollutants is related to respiratory and cardiovascular diseases, several studies have confirmed our hypothesis that breathing polluted air may lead to deterioration of AITD and thyroid function ( 14 , 22 - 26 ). However, the patho-physiological mechanisms linking pollution of ambient air with the function of the thyroid are still unknown.…”

Section: Discussionsupporting

confidence: 76%

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Urban Air Pollution Associated with the Incidence of Autoimmune Thyroid Diseases

Izic¹,

Husejnović²,

Caluk³

et al. 2022

Med Arch

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Background: Endocrine disrupting air pollutants such as sulphur dioxide (SO 2 ), carbon monoxide (CO), nitrogen dioxide (NO 2 ), fine particle matter (PM 2.5 ), and ozone (O 3 ) can affect thyroid gland function on the level of synthesis, metabolism, and the action of its hormones. Objective: The aim of this study was to establish whether increased air pollution could contribute to an increased incidence of autoimmune thyroid diseases (AITD). Methods: A retrospective analysis was conducted of the medical records of 82000 patients at the University Clinical Centre in Tuzla, Bosnia and Herzegovina. The target group of this study comprised a total of 174 patients from the Lukavac area. Daily data on concentrations of air pollutants were collected from the air quality monitoring station located in Lukavac. The study covered the period from 2015 to 2020. Results: The results of the monitoring confirmed the presence of air pollutants in concentrations above the permitted limits throughout the entire observed period. Concentrations of PM 2.5 , SO 2 , NO 2 , CO, and O 3 were in the range of 1.90–431.40 μg/m 3 , 3.60-620.50 μg/m 3 , 3.40-66.20 μg/m 3 , 48.00-7002.00 μg/m 3 , and 0.70-89.40 μg/m 3 , with means of 64.08 μg/m 3 , 77.48 μg/m 3 , 22.57 μg/m 3 , 1657.15 μg/m 3 , and 31.49 μg/m 3 , respectively. During the six-year period, 174 cases of AITD were registered, of which 150 (86.21%) were women and 24 (13.79%) men. Hashimoto’s thyroiditis was found in 33 patients (18.97%), whilst 141 patients (81.03%) were diagnosed with atrophic thyroiditis. The highest total incidence of autoimmune thyroiditis was recorded in 2017, when it reached 99.49, 95% CI. Conclusion: The effects of chronic exposure to a mixture of air pollutants on the function of the thyroid gland are still not sufficiently well-known, but the numerical tendency towards a higher incidence of AITD in this study, albeit without statistical significance (p>0.05), still underlines the need for additional research.

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Section: Discussionsupporting

confidence: 76%

“…Several studies indicate a correlation between exposure to O 3 and endocrine organ diseases in humans, including the pancreas, thyroid and the adrenal gland ( 26 - 28 ). Our research did not show any correlation between exposure to O 3 and the total incidence of AITD.…”

Section: Discussionmentioning

confidence: 99%

Urban Air Pollution Associated with the Incidence of Autoimmune Thyroid Diseases

Izic¹,

Husejnović²,

Caluk³

et al. 2022

Med Arch

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“…Its severe effects now spread beyond . A recent study indicated that maternal exposure to O3 in 1 μg m -3 level increment was positively associated with newborn congenital hypothyroidism(Qi et al, 2021). Carbon monoxide was posing some major health threats to the public.Depending on the length of exposure and the concentration inhaled, it reduces red blood cell oxygen-carrying capacity.…”

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confidence: 99%

Air Quality Status in Wuhan City during and One Year after the COVID-19 Lockdown

Ethan

Mokoena

2022

Aerosol Air Qual. Res.

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Anthropogenic activities have been established to have severe adverse effects on air quality. Consequently, the nature of daily events, directly and indirectly, influences the nature of air pollution observed. This study focused on describing air quality one year after the Coronavirus (COVID-19) pandemic lockdown (since anthropogenic activities had resumed back to normal) in Wuhan.Using the independent t-test, the means of air quality index (AQI) and individual air pollutants concentration during the lockdown were compared with the means after the lockdown. Cohen's d was estimated to quantify the standardized mean difference observed.Based on the average AQI, the air quality in Wuhan during and after the lockdown was rated "good"; and ranged between 59.7 and 99.8. Indicators of traffic pollution, particularly NO2, were significantly higher after the lockdown; noting a 162% increment in concentration. A 36% increase was also noted for ozone immediately after the lockdown; while a 33% increase was noted for SO2 roughly eight months post lockdown. At different periods post lockdown, particulate matter pollution varied, with some time-spans observing lower concentrations and others higher concentrations than the lockdown. A trade-off effect between PM2.5 and O3 was also noted during and after the lockdown.One year post the lockdown, air quality in Wuhan has observed some drastic changes. Hence, there is a need for more studies to identify other specific and peculiar sources of emissions in the city. Relevant findings should be employed in supporting the implementation of stringent emission control.

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“…In contrast, another study conducted by Cuifang Qi et al has mentioned that O3 and NO2 exposure in the mother possibly in uences CHT [34]. If air pollution increases the thyroxine-binding globulin (TBG) levels, neonatal T4 concentration could increase while neonatal FT4 could decrease [15,29].…”

Section: Discussionmentioning

confidence: 95%

Air pollution and thyroid abnormalities: Systematic review and meta-analysis

Rohani

Rezayat

Rohani

et al. 2023

Preprint

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Background Air pollution exposure can trigger a wide range of thyroid dysfunction in different population groups. This systematic review and meta-analysis aimed to find the association between air pollution and thyroid dysfunction in the general population and neonate, pregnant and cancerous people. Methods Electronic databases, including Web of Science, PubMed, Scopus, and Embase, were searched for all published articles from 27 October 2021. The Newcastle Ottawa Scale checklist was used to assess the quality of individual studies. Relevant demographic data and the intended results of the selected studies were extracted, and their adjusted odds ratios were pooled using random and fixed effect analysis based on the heterogenicity index. Results After applying the search strategies, twenty-six articles were included in our study. Overall, the association between air pollution and thyroid cancer, neonatal hypothyroidism, maternal thyroid function, and thyroid function in the general population was discussed in four, eight, ten, and four studies, respectively. There was a significant association between PM2.5 exposure and maternal hypothyroxinemia with pooled OR of 1.241 (95%CI, 1.089–1.415), p-value < 0.001. No positive relationship existed between NO2 exposure and maternal hypothyroxinemia with pooled OR of 1.007 (95%CI, 0.840–1.207), p-value = 0.941. The investigation of the relationship between PM2.5 exposure and congenital hypothyroxinemia showed a significant association between them, with pooled OR of 1.017 (95%CI, 1.002–1.032), p-value = 0.024. Conclusions Air pollution could influence thyroid function, especially in pregnant women and newborn infants. This study and similar investigations provide evidence of air pollution toxicity for healthcare systems.

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Maternal exposure to O3 and NO2 may increase the risk of newborn congenital hypothyroidism: a national data-based analysis in China

Cited by 7 publications

References 49 publications

Urban Air Pollution Associated with the Incidence of Autoimmune Thyroid Diseases

Urban Air Pollution Associated with the Incidence of Autoimmune Thyroid Diseases

Air Quality Status in Wuhan City during and One Year after the COVID-19 Lockdown

Air pollution and thyroid abnormalities: Systematic review and meta-analysis

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