Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies

Bongaerts, Eva; Lecante, Laetitia L; Bové, Hannelore; Roeffaers, Maarten; Ameloot, Marcel; Fowler, Paul A.; Nawrot, Tim S.

doi:10.1016/s2542-5196(22)00200-5

Cited by 79 publications

(59 citation statements)

References 46 publications

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“… 31 For black carbon measurements, cord blood samples were thawed at room temperature, vortexed (VWR International), and

was pipetted into imaging chambers fabricated in-house. 8 Two imaging chambers were prepared per participant. Imaging chambers were constructed by placing a glass coverslip (

; no.…”

Section: Methodsmentioning

confidence: 99%

“… 3 , 4 After inhalation, black carbon particles smaller than

can bypass the lung–blood barrier 5 and translocate to distal body sites, as substantiated by their presence in urine, 6 placental tissue, 7 and cord blood. 8 Quantified black carbon loads in these biological matrices correlate well with modeled prenatal and postnatal air pollution exposure and are therefore employed as individual internal exposure biomarkers. 6 – 8 …”

Section: Introductionmentioning

confidence: 99%

“… 8 Quantified black carbon loads in these biological matrices correlate well with modeled prenatal and postnatal air pollution exposure and are therefore employed as individual internal exposure biomarkers. 6 – 8 …”

Section: Introductionmentioning

confidence: 99%

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Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIR ON AGE Birth Cohort

Pee

Hogervorst

Dockx

et al. 2023

Environ Health Perspect

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Background: The gut microbiome plays an essential role in human health. Despite the link between air pollution exposure and various diseases, its association with the gut microbiome during susceptible life periods remains scarce. Objectives: In this study, we examined the association between black carbon particles quantified in prenatal and postnatal biological matrices and bacterial richness and diversity measures, and bacterial families. Methods: A total of 85 stool samples were collected from 4- to 6-y-old children enrolled in the ENVIRonmental influence ON early AGEing birth cohort. We performed 16S rRNA gene sequencing to calculate bacterial richness and diversity indices (Chao1 richness, Shannon diversity, and Simpson diversity) and the relative abundance of bacterial families. Black carbon particles were quantified via white light generation under femtosecond pulsed laser illumination in placental tissue and cord blood, employed as prenatal exposure biomarkers, and in urine, used as a post-natal exposure biomarker. We used robust multivariable-adjusted linear models to examine the associations between quantified black carbon loads and measures of richness (Chao1 index) and diversity (Shannon and Simpson indices), adjusting for parity, season of delivery, sequencing batch, age, sex, weight and height of the child, and maternal education. Additionally, we performed a differential relative abundance analysis of bacterial families with a correction for sampling fraction bias. Results are expressed as percentage difference for a doubling in black carbon loads with 95% confidence interval (CI). Results: Two diversity indices were negatively associated with placental black carbon [Shannon: (95% CI: , ); Simpson: (95% CI: , )], cord blood black carbon [Shannon: (95% CI: , ); Simpson: (95% CI: , )], and urinary black carbon [Shannon: (95% CI: , ); Simpson: (95% CI: , )]. The explained variance of black carbon on the above indices varied from 6.1% to 16.6%. No statistically significant associations were found between black carbon load and the Chao1 richness index. After multiple testing correction, placental black carbon was negatively associated with relative abundance of the bacterial families Defluviitaleaceae and Marinifilaceae , and urinary black carbon with Christensenellaceae and Coriobacteriaceae ; associations with cord blood black carbon were not statistically significant after correction. Conclusion: Black carbon particles quantified in prenatal and postnatal biological matrices were as...

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“… 31 For black carbon measurements, cord blood samples were thawed at room temperature, vortexed (VWR International), and

was pipetted into imaging chambers fabricated in-house. 8 Two imaging chambers were prepared per participant. Imaging chambers were constructed by placing a glass coverslip (

; no.…”

Section: Methodsmentioning

confidence: 99%

“… 3 , 4 After inhalation, black carbon particles smaller than

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIR ON AGE Birth Cohort

Pee

Hogervorst

Dockx

et al. 2023

Environ Health Perspect

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“…For example, plastic pollution can lead to synthetic fibers and microplastics entering the human body through food and air (De-la-Torre, 2020;Wang et al, 2021). Indeed, microplastics have been found in the human placenta (Ragusa et al, 2021), and carbon particles from air pollution have been found in the lung and brain tissue of unborn babies (Bongaerts et al, 2022).…”

Section: Fossil Fuelsmentioning

confidence: 99%

Health Psychology and Climate Change: Time to address humanity’s most existential crisis

Papies¹,

Nielsen²,

Soares³

2023

Preprint

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Climate change is an ongoing and escalating health emergency. It threatens the health and wellbeing of billions of people, through extreme weather events, displacement, food insecurity, pathogenic diseases, societal destabilisation, and armed conflict. Climate change dwarfs all other challenges studied by health psychologists. The greenhouse gas emissions driving climate change disproportionately originate from the actions of wealthy populations in the Global North and are tied to excessive energy use and overconsumption driven by the pursuit of economic growth. Addressing this crisis requires significant societal transformations and individual behaviour change. Most of these changes will benefit not only the stability of the climate but will yield significant public health co-benefits. Because of their unique expertise and skills, health psychologists are urgently needed in crafting climate change mitigation responses. We propose specific ways in which health psychologists at all career stages can contribute, within the spheres of research, teaching, and policy making, and within organisations and as private citizens. As health psychologists, we cannot sit back and leave climate change to climate scientists. Climate change is a health emergency that results from human behaviour; hence it is in our power to address it.

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“…Polluted air is also known to impact the health of children even before they are born, correlating strongly with miscarriages, premature births, low birth weight, and brain development 3. It is extremely concerning to see new research published this month showing the impact of toxic air pollution particles on the lungs, livers, and brains of unborn babies — confirming the direct harm caused to the fetus by dirty air 4…”

mentioning

confidence: 99%

Children have a right to clean air, and we must fight for it to become a reality

Kingdon

2022

BMJ

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Children have a right to clean air, and we must fight for it to become a reality Air pollution is complex-but the WHO air quality targets are clear, writes Camilla Kingdon Camilla Kingdon President"Legally binding targets based on WHO guidelines would reduce the number of deaths from air pollution in the UK." 1 This was the clear conclusion from the coroner following the death of nine-year-old Ella Adoo-Kissi-Debrah in 2013 following an asthma attack. Ella was the first person in the UK to have air pollution listed as a cause of death. 2 As paediatricians we are committed to learning from this very tragic example-no other child in the UK should be allowed to suffer the way that Ella did.

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Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies

Cited by 79 publications

References 46 publications

Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIR ON AGE Birth Cohort

Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIR ON AGE Birth Cohort

Health Psychology and Climate Change: Time to address humanity’s most existential crisis

Children have a right to clean air, and we must fight for it to become a reality

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