Maternal epigenetics and fetal and neonatal growth

Kitsiou-Tzeli, Sofia; Tzetis, Maria

doi:10.1097/med.0000000000000305

Cited by 72 publications

(58 citation statements)

References 30 publications

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“…14 The lack of association between maternal ferritin at 32 weeks gestation and child growth at 36 months of age raises the possibility that robust in utero iron concentrations are most critical in the early stages of pregnancy, for optimal postnatal child growth outcomes. Rapid fetal growth begins from 9 weeks after conception, and poor maternal nutritional status during the first trimester may have a significant impact …”

Section: Bmj Global Healthmentioning

confidence: 99%

Effect of low-dose versus higher-dose antenatal iron supplementation on child health outcomes at 36 months of age in Viet Nam: longitudinal follow-up of a cluster randomised controlled trial

et al. 2017

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IntroductionIntermittent iron-folic acid supplementation (IFA) is currently recommended for pregnant women in populations where anaemia prevalence among pregnant women is <20% or if daily iron is not acceptable. The effect of providing lower doses of antenatal elemental iron through intermittent regimes on longer-term health outcomes in childhood is unclear.MethodsA prospective cohort study conducted between May 2012 and May 2014 in Viet Nam among children of 36 months of age, born to women previously enrolled in a cluster randomised controlled trial of antenatal micronutrient supplementation (daily IFA (60 mg elemental iron) vs twice-weekly IFA (60 mg elemental iron) vs twice-weekly multiple micronutrient (MMN) supplementation (60 mg elemental iron)). Primary outcomes were height-for-age z-scores (HAZ), according to WHO growth standards and cognitive composite scores (Bayley Scales of Infant and Toddler Development, third edition) at 36 months of age.ResultsA total of 1017 children born to mothers enrolled in the cluster randomised trial were assessed at 36 months of age. Adjusted mean differences (MDs) in HAZ were –0.14 (95% CI –0.28 to –0.01) and –0.15 (95% CI –0.29 to –0.01) in children born to mothers who received twice-weekly IFA or MMN compared with those who received daily IFA. Children born to mothers who received twice-weekly MMN had lower composite motor scores compared with those who received daily IFA (MD –2.07, 95% CI –4.11 to –0.03). There were no differences in composite cognitive scores in the twice-weekly compared with daily regimens.ConclusionsLow-dose antenatal IFA supplementation (120 mg elemental iron per week) resulted in lower HAZ and motor composite scores in children compared with higher-dose antenatal IFA supplementation (420 mg elemental iron per week). This highlights the importance of adequate iron stores during pregnancy and the need for careful monitoring when lower-dose antenatal iron regimens are used.Trial registration numberAustralia New Zealand Clinical Trials Registry: 12610000944033.

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Section: Bmj Global Healthmentioning

confidence: 99%

Effect of low-dose versus higher-dose antenatal iron supplementation on child health outcomes at 36 months of age in Viet Nam: longitudinal follow-up of a cluster randomised controlled trial

et al. 2017

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“…Several authors have already reported that maternal malnutrition during pregnancy and lactation can be harmful to the birth weight and metabolic homeostasis of the offspring [5][6][7]. Complementarily, few recent studies have demonstrated the association among maternal diet restriction, disturbances in the miRNA expression and metabolic diseases onset in life [6,7].…”

Section: Maternal Under-nutrition and Mirna Expression In Offspringmentioning

confidence: 99%

“…Approximately 2,800 mammalian miRNAs have been annotated and these miRNAs are potentially target up to 60% of protein-coding genes [3]. In addition, disturbances in the miRNA expression are linked to aberrant metabolic changes and onset of diseases [5].…”

Section: Epigenetic Plasticity and Mirna Expressionmentioning

confidence: 99%

“…Epigenetic is based on inheritable changes that regulate tissue-specific gene expression, without altering the DNA sequences [4,5]. The major epigenetic determinants are DNA methylation, histone modification signatures (e.g.…”

Section: Epigenetic Plasticity and Mirna Expressionmentioning

confidence: 99%

“…The major epigenetic determinants are DNA methylation, histone modification signatures (e.g. methylation, acetylation and phosphorylation), chromatin conformation and non-coding RNA, including microRNA (miRNA) [4,5].…”

Section: Epigenetic Plasticity and Mirna Expressionmentioning

confidence: 99%

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