Maternal enrichment affects prenatal hippocampal proliferation and open-field behaviors in female offspring mice

Maruoka, Takashi; Kodomari, Ikuko; Yamauchi, Rena; Wada, Etsuko; Wada, Keiji

doi:10.1016/j.neulet.2009.02.052

Cited by 36 publications

(28 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in the less confined open field, sex differences emerged: in males, PE tended to PS-like reduced exploration, contrasting with PE-increased female exploration. The latter is consistent with previous findings, and with repeated testing (Dell & Rose, 1987), and with gestational enrichment (Maruoka, Kodomari, Yamauchi, Wada, & Wada, 2009;Welberg, Thrivikraman, & Plotsky, 2006). Similarly, PE-impoverished social interaction in males is a PSlike effect, whereas PE had little effect on female social interaction.…”

Section: Effects Of Prereproductive Enrichment (Pe) On Progenysupporting

confidence: 92%

Transgenerational effects of infantile adversity and enrichment in male and female rats

Leshem

Schulkin

2011

Developmental Psychobiology

View full text Add to dashboard Cite

To discover whether the accumulation of life's experiences, adverse and enriching, inform, and serve the following generation by inheritance we examine whether stress to a weanling female will influence her future offspring, whether prereproductive enrichment to the dam, or postweaning enrichment to the offspring, can reverse the transgenerational effects of stress, and whether, like adversity, enrichment might have transgenerational effects. Female rats were exposed to stressors when they were 27-29 days old. Half of these females and their controls were then raised in an enriched environment from weaning until mating at 60 days to examine whether preproduction enrichment reverses the effects of preproduction stress on offspring. Half of the offspring of each group were raised in an enriched environment after weaning, to see whether it reverses the effects of preproduction stress and buttresses prereproductive enrichment. Behavior was examined in 625 adult offspring in 16 groups covering all permutations of the experimental variables (preproduction weanling stress (PS), preproduction enrichment (PE), offspring enrichment (OE), sex). Exploration, avoidance learning, startle, and social interaction were tested. Results reveal that very early prereproductive experience in females, adverse or enriching, will transgenerationally influence their future offspring, depending on the behavior tested and sex. Our finding that enrichment, whether to the parent or offspring generation, can ameliorate the transgenerational impact of adversity, has novel implications for the malleability of transgenerational inheritance, and its individual, social, and therapeutic impact.

show abstract

Section: Effects Of Prereproductive Enrichment (Pe) On Progenysupporting

confidence: 92%

Transgenerational effects of infantile adversity and enrichment in male and female rats

Leshem

Schulkin

2011

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…We can also hypothesize that maternal corticosterone influenced the foetus during gestation crossing the placenta. The idea that the effect of EE in the mother can be passed to the offspring during embryogenesis is consistent with some studies showing that exposure of pregnant rats to EE enhances learning abilities [18,19], locomotor activity, anxiety-like behaviour [20,21], neurogenesis, synaptic markers and neurotrophic factors [19,73] in their offspring. On the basis that exposure to corticosterone during development is able to modify the hippocampal structure and morphology [74][75][76], we can suppose that the foetal exposure to glucocorticoid could have affected the hippocampal development and then the behavioural outcomes later in their life.…”

Section: Accepted Manuscriptsupporting

confidence: 85%

Maternal exposure to environmental enrichment before and during gestation influences behaviour of rat offspring in a sex-specific manner

Zuena

Zinni

Giuli

et al. 2016

Physiology & Behavior

View full text Add to dashboard Cite

“…It is also important to address that the presence of a running wheel in the cage may serve as enrichment for the exercising dams. Although no studies have been conducted to look at maternal environmental enrichment and its effects on the metabolic health of offspring, a few animal studies have shown that it can improve maternal and offspring cognitive functions (24,27,42). It may be necessary in future studies to control for this as a possible confounding factor by using a controlled exercised paradigm in which there is no running wheel in the home cage.…”

Section: Discussionmentioning

confidence: 99%

Perinatal exercise improves glucose homeostasis in adult offspring

Carter

Lewis

Wilkerson

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

138

View full text Add to dashboard Cite

Emerging research has shown that subtle factors during pregnancy and gestation can influence long-term health in offspring. In an attempt to be proactive, we set out to explore whether a nonpharmacological intervention, perinatal exercise, might improve offspring health. Female mice were separated into sedentary or exercise cohorts, with the exercise cohort having voluntary access to a running wheel prior to mating and during pregnancy and nursing. Offspring were weaned, and analyses were performed on the mature offspring that did not have access to running wheels during any portion of their lives. Perinatal exercise caused improved glucose disposal following an oral glucose challenge in both female and male adult offspring (P Ͻ 0.05 for both). Blood glucose concentrations were reduced to lower values in response to an intraperitoneal insulin tolerance test for both female and male adult offspring of parents with access to running wheels (P Ͻ 0.05 and P Ͻ 0.01, respectively). Male offspring from exercised dams showed increased percent lean mass and decreased fat mass percent compared with male offspring from sedentary dams (P Ͻ 0.01 for both), but these parameters were unchanged in female offspring. These data suggest that short-term maternal voluntary exercise prior to and during healthy pregnancy and nursing can enhance long-term glucose homeostasis in offspring.running; pregnancy; programming; mice IN 2007, 23.5 MILLION PEOPLE in the US were estimated to have diabetes, and this number is increasing (4). Interestingly, and what is often underappreciated, is that the metabolic status of an individual is decided not only by their inherited genes, nutritional intake, and physical exercise but also by maternal nutrition and obesity during pregnancy. In 1992, Hales and Barker (18) put forth the thrifty phenotype hypothesis that suggested that malnourished pregnant mothers produce smaller offspring that have a higher incidence of obesity, diabetes, and heart disease in adulthood. This hypothesis has since been modified to the developmental origins of health and disease (DOHaD) (15,17,18).The DOHaD suggests that the maternal environment and fetal programming lead to a higher incidence of several diseases later in life (14, 16). A growing number of studies have been designed to provide evidence for the negative impact of DOHaD, using mice, rats, and sheep as animal models (11,12,31,38). Many of these studies are directed at malnutrition through protein restriction or physical stressors that produce similar effects (8,11,34,44,45), but more recent studies are elucidating the metabolic effects of high-fat diet consumption during pregnancy on offspring (22,38,44,48).It has been known since Hippocrates and Galen that physical activity is an important component of a healthy lifestyle (33). However, knowledge about the contributions of maternal exercise during pregnancy and the long-term consequences on offspring is minimal. In both rats and mice, maternal exercise during pregnancy can improve brain physiology and cognition...

show abstract

Maternal enrichment affects prenatal hippocampal proliferation and open-field behaviors in female offspring mice

Cited by 36 publications

References 25 publications

Transgenerational effects of infantile adversity and enrichment in male and female rats

Transgenerational effects of infantile adversity and enrichment in male and female rats

Maternal exposure to environmental enrichment before and during gestation influences behaviour of rat offspring in a sex-specific manner

Perinatal exercise improves glucose homeostasis in adult offspring

Contact Info

Product

Resources

About