Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review

Naidoo, Nitalia; Moodley, Jagidesa; Naicker, Thajasvarie

doi:10.1038/s41440-020-00604-y

Cited by 15 publications

(30 citation statements)

References 142 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our group also demonstrated the role of various other angiogenic factors in PE development [16,[85][86][87][88][89][90]. We have shown an elevation of TN-C [86], Ang-2 and Eng [87], sVEGFR-1 with concurrent reduction in PECAM-1 and sVEGFR-2 levels [88] and a downregulation in plasma NF-κB and IκB-α expression [90] in PE versus normotensive pregnancies, regardless of HIV status, indicative of their potential role in PE development.…”

Section: Angiogenic Imbalance In Preeclampsiasupporting

confidence: 60%

“…We have shown an elevation of TN-C [86], Ang-2 and Eng [87], sVEGFR-1 with concurrent reduction in PECAM-1 and sVEGFR-2 levels [88] and a downregulation in plasma NF-κB and IκB-α expression [90] in PE versus normotensive pregnancies, regardless of HIV status, indicative of their potential role in PE development. However, HIV status did not affect the expression of sTie2 and sHER2 [85] nor sE-selectin [16] in our cohorts, regardless of pregnancy type, which is suggestive that HAART reconstitutes the immune system. Our research group has recently established that, in PE, a pre-delivery sFlt-1/PIGF proportion (<181.5) is an encouraging predictor value for excluding the need for >3 slow-acting and/or a rapid-acting antihypertensive drug management in the immediate postpartum period [89].…”

Section: Angiogenic Imbalance In Preeclampsiamentioning

confidence: 55%

“…The higher prevalence and mortality rates observed among PE cases are associated with ART use in comparison to HIV infection alone [16]. In the event of HIV infection, a pregnant women's adherence to ART increases the risk of pre-term birth [119,120].…”

Section: Antiretroviral Therapy and Preeclampsiamentioning

confidence: 99%

“…The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is also associated with an increased risk of severe outcomes in pregnancy than the general population [12][13][14]. The SARS-CoV-2 infection superimposed on HIV-associated pregnancy is complex as both impact the inflammatory response and influence endothelial function [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…The consequent hypoxic conditions promote widespread oxidative stress, angiogenic imbalance and an amplified immune and inflammatory response [19]. Endothelial dysfunction induces the maternal syndrome of PE [16].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

HIV Associated Preeclampsia: A Multifactorial Appraisal

Naicker

Govender

Abel

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Introduction: This review explores angiogenesis, vascular dysfunction, the complement system, RAAS, apoptosis and NETosis as potential pathways that are dysregulated during preeclampsia, HIV infection and ART usage. Results: HIV-1 accessory and matrix proteins are protagonists for the elevation of oxidative stress, apoptosis, angiogenesis, and elevation of adhesion markers. Despite the immunodeficiency during HIV-1 infection, HIV-1 exploits our cellular defence arsenal by escaping cell-mediated lysis, yet HIV-1 infectivity is enhanced via C5a release of TNF-α and IL-6. This review demonstrates that PE is an oxidatively stressed microenvironment associated with increased apoptosis and NETosis, but with a decline in angiogenesis. Immune reconstitution in the duality of HIV-1 and PE by protease inhibitors, HAART and nucleoside reverse transcriptase, affect similar cellular pathways that eventuate in loss of endothelial cell integrity and, hence, its dysfunction. Conclusions: HIV-1 infection, preeclampsia and ARTs differentially affect endothelial cell function. In the synergy of both conditions, endothelial dysfunction predominates. This knowledge will help us to understand the effect of HIV infection and ART on immune reconstitution in preeclampsia.

show abstract

Section: Angiogenic Imbalance In Preeclampsiasupporting

confidence: 60%

Section: Angiogenic Imbalance In Preeclampsiamentioning

confidence: 55%

Section: Antiretroviral Therapy and Preeclampsiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

HIV Associated Preeclampsia: A Multifactorial Appraisal

Naicker

Govender

Abel

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Immunoexpression of neuropilin-1 in the chorionic villi of HIV-infected preeclamptic South African women of African ancestry

Naidoo

Abel

Moodley

et al. 2023

Histochem Cell Biol

Self Cite

View full text Add to dashboard Cite

Neuropilin-1 (NRP-1) is an essential regulator of maternal immune tolerance, placentation, and angiogenesis. Its dysregulation in preeclampsia (PE) and human immunodeficiency virus (HIV) infection implicates NRP-1 in disease susceptibility and progression. Therefore, this study investigates placental NRP-1 immunoexpression in HIV-complicated preeclamptic pregnancies in South African women of African ancestry receiving antiretroviral therapy. Immunohistochemistry of recombinant anti-neuropilin-1 antibody was performed on placental tissue from 30 normotensive and 60 early onset (EOPE) and late-onset (LOPE) preeclamptic women stratified by HIV status. Qualitative analysis of NRP-1 immunostaining within the chorionic villi revealed a predominant localization in trophoblasts and syncytial knots as well as endothelial, fibroblast-like, and Hofbauer cells. Following morphometric evaluation, we report that PE and HIV infection and/or antiretroviral usage independently downregulate placental NRP-1 immunoexpression; however, as a comorbidity, this decline is further augmented within the conducting and exchange villi. Furthermore, reduced immunoexpression of NRP-1 in EOPE compared with LOPE villi may be due to maternal–fetal maladaptation. It is plausible that the decreased NRP-1 immunoexpression in PE placentae facilitates syncytiotrophoblast apoptosis and subsequent deportation of NRP-1 into the maternal circulation, contributing to the anti-angiogenic milieu of PE. We hypothesize that the intense NRP-1 immunoreactivity observed in Hofbauer cells at the maternal–fetal interface may contribute to the natural prevention mechanism of HIV vertical transmission.

show abstract