“…76,77,134,147,168 Approximately two-thirds of these pertinent studies addressed motherinfant relationships and one-third addressed mother-toddler relationships, reporting decreased maternal sensitivity, 59,92,166,167,169,172,177,178 more neutral maternal affect, 178 lower structuring and higher intrusiveness, 170 more harsh parenting, 170,179 higher maternal rigidity, 174 lower reflective function, 77 and high rates of parent-child separation. 134 Of the articles relevant to relational and child outcomes which reported on substance use, four addressed offspring outcomes, 62,147,171,175 with two reporting on child socioemotional development, 62,171 one reporting on child temperament, 147 and another reporting on child internalizing symptoms. 175 Given study heterogeneity and the low number of studies, it is difficult to make definitive conclusions, though one longitudinal study reported that prenatal substance use mediated the relationship between maternal childhood maltreatment experiences and young child internalizing symptoms.…”