Maternal effects on mouse brain weight

Wahłsten, Douglas

doi:10.1016/0165-3806(83)90054-8

Cited by 22 publications

(9 citation statements)

References 23 publications

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“…Our results also demonstrated that with the exception of motor differences in swim speed, where the mice born to 129 mothers were swimming faster than their counterparts born to FVB dams, we did not observe any maternal effect on cognitive function or brain weight in adult 129FVBF1 progeny. Similar maternal effects on the body weights in reciprocal crosses of other strains were reported previously [56]. In conclusion, the employment of reciprocal crosses in our studies revealed maternal effects on body weight in adult mice, however, the genotype of the mother did not affect the response to cryoanesthesia, adult cognitive function, or brain weight of F1 progeny.…”

Section: Discussionsupporting

confidence: 90%

“…Also, the experimental end-point analysis of the brain weight also revealed no differences between neonatally cryoanesthetized and control mice. The average brain weights of 0.500g ± 0.004; 0.497g ± 0.004 for Cryo6 and Cryo12 mice, respectively, were comparable to the brain weight of the control mice (0.495g ± 0.004), and were within a range of the brain weights reported in the literature [56, 57]. Although we cannot exclude subtle changes in the dendritic arborization reported by Kolb and Cioe [36], the lack of differences in several behavioural measures and in a general physical development suggests that such differences, if exist, might have a minimal effect on adult cognitive function in a mouse, and in most cases might not be detected in cognitive tests.…”

Section: Discussionsupporting

confidence: 79%

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The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice

Janus

Golde

2014

Behavioural Brain Research

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Deep hypothermia (cryoanesthesia) is often used as general anesthesia during surgery in neonatal rodents. Neonatal cryoanesthesia has been used recently to generate somatic brain transgenic (SBT) mouse models via intracerebral ventricular injection of rAAV vectors into both non-transgenic mice and numerous transgenic mouse models. Since, the evaluation of cognition is one of the main experimental endpoints in many of these studies, we examined the consequences of brief neonatal cryoanesthesia on the physical development and mnemonic function of adult mice. Two groups of 129FVBF1 pups from reciprocal breeding crosses underwent cryoanesthesia for 6 (Cryo6) or 12 (Cryo12) min, respectively, within the first hours (< 12hr) of postnatal life. A group of pups separated from the nest and kept in ambient temperature of 33 °C for 6 min served as a control. Our results revealed that lowering the temperature of pups to ~8 °C (Cryo6) or ~5 °C (Cryo12) did not affect their body weight at pre-weaning stage and in the adulthood. The evaluation of cognitive function in adult mice revealed strong and comparable to controls spatial reference, and context and tone fear memories of neonatally cryoanesthetized mice. Also, the experimental and control groups had comparable brain weight at the end of the study. Our results demonstrate that neonatal cryoanesthesia, lasting up to 12 min, has no adverse effects on the body weight of mice during development, and on their cognition in the adulthood.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 79%

The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice

Janus

Golde

2014

Behavioural Brain Research

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“…The range of ages when the brains were extracted varied from a minimum of 8 weeks to over a year for some mice employed as breeders. Brain size differs substantially among mouse strains, is larger in hybrid crosses than their inbred parents, shows marked maternal environment effects (Wahlsten 1983), increases substantially with age of the animal (Wahlsten 1975(Wahlsten , 1984 and is also influenced by litter size (Bulman-Fleming & Wahlsten 1988). It is well known from the principle of allometry that a larger brain tends to have larger parts (Gould 1966).…”

Section: Criteria For Abnormalitymentioning

confidence: 99%

Hippocampal commissure defects in crosses of four inbred mouse strains with absent corpus callosum

Bohlen¹,

Bailoo²,

Jordan³

et al. 2012

Genes Brain and Behavior

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It is known that four common inbred mouse strains show defects of the forebrain commissures. The BALB/cJ strain has a low frequency of abnormally small corpus callosum, while the 129 strains have many animals with deficient corpus callosum. The I/LnJ and BTBR T+ tf/J strains never have a corpus callosum, while half of I/LnJ and almost all BTBR show severely reduced size of the hippocampal commissure. Certain of the F1 hybrid crosses among these strains are known to be less severely abnormal than the inbred parents, suggesting the parent strains have different genetic causes of commissure defects. In this study, all hybrid crosses among the four strains were investigated. The BTBR x I/Ln hybrid expressed almost no defects of the hippocampal commissure, unlike its inbred parent strains. Numerous 3-way crosses among the four strains yielded many mice with no corpus callosum and severely reduced hippocampal commissure, which shows that the phenotypic defect can result from several different combinations of genetic alleles. The F2 and F3 hybrid crosses of BTBR and I/LnJ had almost 100% absence of the corpus callosum but about 50% frequency of deficient hippocampal commissure. The 4-way hybrid cross among all four abnormal strains involved highly fertile parents and yielded a very wide phenotypic range of defects from almost no hippocampal commissure to totally normal forebrain commissures. The F2 and F3 crosses as well as the 4-way cross provide excellent material for studies of genetic linkage and behavioral consequences of commissure defects.

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“…anesthetized with an overdose of sodium pentobarbital, and perfused intracardially with 0.9% saline followed by buffered 10% Formalin. Brains were extracted and stored in Formalin for 1 week prior to being trimmed to a standard configuration (25) and weighed to the nearest milligram. The cerebellum was then removed and weighed to the nearest 0.1 mg. Five 33-μm serial frozen sections were cut from each left hemisphere starting at midplane and sections were wet-mounted using Aquamount.…”

Section: Histology and Fiber Tract Measurement At Between 99 And 102mentioning

confidence: 99%

“…Although this could occur because of polygenic inheritance, it might also reflect a superior hybrid maternal environment which promotes better brain growth. (25).…”

Section: Introductionmentioning

confidence: 99%

Effects of a hybrid maternal environment on brain growth and corpus callosum defects of inbred BALBc mice: A study using ovarian grafting

Bulman-Fleming

Wahłsten

1988

Experimental Neurology

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The corpus callosum of many but not all BALB/c mice is either abnormally small or absent. The basis for the defect is hereditary, but the proportion of mice expressing the anomaly can be modified by changing the early environment. The present study investigated the effects of an F1 hybrid maternal environment, which is known to promote better fetal development than an inbred environment, on body and brain growth in BALB/c and on the incidence of the corpus callosal defect. Ovarian follicle cells from BALB/cWah (albino) mice were grafted into pigmented F1 hybrid, BALB/cWah, and pigmented BALB female hosts of comparable age which were subsequently mated to BALB/cWah males. Groups of unoperated BALB/cWah and pigmented BALB dams were included as controls. Data from 111 litters were analyzed. Results showed that BALB mice with F1 mothers had heavier bodies at birth, weaning, and 100 days of age and heavier brains at 100 days than those with either grafted or ungrafted BALB mothers. The effects at birth were evident across all litter sizes (2 to 11), but those at weaning and 100 days were seen only in litters of more than 5 or 6. Neither the F1 hybrid maternal environment nor the grafting procedure itself appeared to influence the incidence or expression of the corpus callosal defect. About 22% of the offspring from each of the three groups (ungrafted BALB, grafted BALB, and grafted F1) showed a defective corpus callosum.

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Maternal effects on mouse brain weight

Cited by 22 publications

References 23 publications

The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice

The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice

Hippocampal commissure defects in crosses of four inbred mouse strains with absent corpus callosum

Effects of a hybrid maternal environment on brain growth and corpus callosum defects of inbred BALBc mice: A study using ovarian grafting

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