Maternal diet-induced obesity during suckling period programs offspring obese phenotype and hypothalamic leptin/insulin resistance

Gomes, Rodrigo Mello; Bueno, Fernanda; Schamber, Christiano Rodrigues; Mello, João Carlos Palazzo de; Oliveira, Júlio Cézar de; Francisco, Flávio Andrade; Moreira, Veridiana Mota; Ferreira-Junior, Marcos Divino; Pedrino, Gustavo Rodrigues; Mathias, Paulo Cézar de Freitas; Miranda, Rosiane Aparecida; Moraes, Solange Marta Franzói de; Natali, Maria Raquel Marçal

doi:10.1016/j.jnutbio.2018.07.006

Cited by 53 publications

(41 citation statements)

References 33 publications

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“…Transcriptomic assessment of baboon fetal livers born to mothers fed high-fat/high-fructose diet indicated dysregulation of the TCA cycle, glycolysis, changes in Wnt/β-catenin signaling, and marked lipid accumulation 15 . Epigenome-wide methylation changes 16 and hypothalamic leptin and insulin resistance are postulated to be contributing factors 17 . These studies provide evidence that maternal obesity is a risk factor for offspring metabolic programming.…”

Section: Ghmentioning

confidence: 99%

Offspring susceptibility to metabolic alterations due to maternal high-fat diet and the impact of inhaled ozone used as a stressor

Snow

Broniowska

Karoly

et al. 2020

Sci Rep

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The influence of maternal high-fat diet (HFD) on metabolic response to ozone was examined in Long-Evans rat offspring. F0 females were fed control diet (CD; 10%kcal from fat) or HFD (60%kcal from fat) starting at post-natal day (PND) 30. Rats were bred on PND 72. Dietary regimen was maintained until PND 30 when all offspring were switched to CD. On PND 40, F1 offspring (n = 10/group/sex) were exposed to air or 0.8 ppm ozone for 5 h. Serum samples were collected for global metabolomic analysis (n = 8/group/sex). Offspring from HFD dams had increased body fat and weight relative to CD. Metabolomic analysis revealed significant sex-, diet-, and exposure-related changes. Maternal HFD increased free fatty acids and decreased phospholipids (male > female) in air-exposed rats. Microbiome-associated histidine and tyrosine metabolites were increased in both sexes, while 1,5-anhydroglucitol levels decreased in males indicating susceptibility to insulin resistance. Ozone decreased monohydroxy fatty acids and acyl carnitines and increased pyruvate along with TCA cycle intermediates in females (HFD > CD). Ozone increased various amino acids, polyamines, and metabolites of gut microbiota in HFD female offspring indicating gut microbiome alterations. Collectively, these data suggest that maternal HFD increases offspring susceptibility to metabolic alterations in a sex-specific manner when challenged with environmental stressors.

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Section: Ghmentioning

confidence: 99%

Offspring susceptibility to metabolic alterations due to maternal high-fat diet and the impact of inhaled ozone used as a stressor

Snow

Broniowska

Karoly

et al. 2020

Sci Rep

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“…The meta-analysis conducted by Ribaroff et al [ 20 ] on 171 experimental studies identified that the exposure to high fat diet during the lactation period was a key modulator of bodyweight of the offspring at weaning and in adulthood, with a significantly greater effect on offspring fat mass than when WD exposure occurred during pregnancy alone [ 21 ]. High exposure to a WD during the breastfeeding phase is also associated with hyperinsulinemia, hyperglycemia, pancreatic islet hypertrophy, insulin resistance, hyperphagia, and overweight in male offspring [ 22 ]. Indeed, the development of dys-metabolic and non-alcoholic hepatic steatosis phenotype observed in offspring exposed to maternal obesity in the postpartum period has been suggested to be induced by factors in breast milk which probably modify the brain centers of energetic homeostasis [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner

Alexandre-Gouabau

David-Sochard

Royer

et al. 2020

IJMS

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Lactation is a critical period during which maternal sub- or over-nutrition affect milk composition and offspring development that can have lasting health effects. The consequences of moderate high-fat, high-simple carbohydrate diet (WD) consumption by rat dams, during gestation and lactation, on milk composition and offspring blood lipidome and its growth, at weaning, were investigated by using a comprehensive lipidomic study on mass-spectrometric platform combined to targeted fatty- and free amino-acids analysis. This holistic approach allowed clear-cut differences in mature milk-lipidomic signature according to maternal diet with a similar content of protein, lactose and leptin. The lower WD-milk content in total fat and triglycerides (TGs), particularly in TGs-with saturated medium-chain, and higher levels in both sphingolipid (SL) and TG species with unsaturated long-chain were associated to a specific offspring blood-lipidome with decreased levels in TGs-containing saturated fatty acid (FA). The sexual-dimorphism in the FA-distribution in TG (higher TGs-rich in oleic and linoleic acids, specifically in males) and SL species (increased levels in very long-chain ceramides, specifically in females) could be associated with some differences that we observed between males and females like a higher total body weight gain in females and an increased preference for fatty taste in males upon weaning.

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“…It has been reported that insulin resistance and chronic inflammation contribute to hepatic lipid accumulation (43). There are also suggested effects of maternal HF diet and GTE intake on the formation of predispositions to hepatic lipid accumulation in offspring (44)(45)(46). Therefore, further study is necessary to clarify the mechanism underlying the preventive effects of maternal GTE intake on hepatic lipid accumulation.…”

Section: Discussionmentioning

confidence: 99%

Maternal green tea extract intake during lactation attenuates hepatic lipid accumulation in adult male rats exposed to a continuous high-fat diet from the foetal period

Yamasaki¹,

Kimura²,

Koizumi³

et al. 2020

Food & Nutrition Research

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Background: Maternal lipid intake in the early postnatal period has a long-term effect on the possibility of fatty liver formation in children; besides, the importance of lipid consumption during lactation for children's health has been suggested. Green tea extract (GTE) contains abundant catechins, and it has been reported to improve lipid metabolism and prevent fatty liver. Objective: The aim of this study was to examine the effects of maternal GTE intake during lactation on hepatic lipid accumulation in adult male rats exposed to a continuous high-fat (HF) diet from the foetal period. Methods: Pregnant Wistar rats received diets containing 13% (control-fat, CON) or 45% (high-fat, HF) fat. CON-fed mothers received the same diet during lactation, whereas HF-fed mothers received either HF diet alone or HF diet supplemented with 0.24% GTE. At weaning, male offspring were divided into three groups, i.e. CON/CON/CON, HF/HF/HF (HF-offspring) or HF/HF+GTE/HF (GTE-offspring), and were fed until 51 weeks. Results: A significant hepatic triglyceride (Tg) accumulation was observed in the HF-offspring when compared with the other offspring. This is presumed to be caused by the promotion of Tg synthesis derived from exogenous fatty acid due to a significant increase in diacylglycerol O-acyltransferase 1 and a decrease in Tg expenditure caused by decreasing microsomal triglyceride transfer protein (MTTP) and long-chain acyl-CoA dehydrogenase. On the other hand, attenuated hepatic Tg accumulation was observed in the GTEoffspring. The levels of the hepatic lipid metabolism-related enzymes were improved to the same level as the CON-offspring, and particularly, MTTP was significantly increased as compared with the HF-offspring. Conclusion: This study indicates the potential protective effects of maternal GTE intake during lactation on HF diet-induced hepatic lipid accumulation in adult male rat offspring and the possible underlying mechanisms.

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Maternal diet-induced obesity during suckling period programs offspring obese phenotype and hypothalamic leptin/insulin resistance

Cited by 53 publications

References 33 publications

Offspring susceptibility to metabolic alterations due to maternal high-fat diet and the impact of inhaled ozone used as a stressor

Offspring susceptibility to metabolic alterations due to maternal high-fat diet and the impact of inhaled ozone used as a stressor

Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner

Maternal green tea extract intake during lactation attenuates hepatic lipid accumulation in adult male rats exposed to a continuous high-fat diet from the foetal period

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