Maternal diet disrupts the placenta–brain axis in a sex-specific manner

Ceasrine, Alexis M; Devlin, Benjamin A.; Bolton, Jessica L.; Green, Lauren; Jo, Yong Suk; Huynh, Carolyn; Patrick, Bailey; Washington, Kamryn; Sánchez, Cristina; Joo, Faith; Campos-Salazar, A. Brayan; Lockshin, Elana R.; Kuhn, Cynthia M.; Murphy, Susan K.; Simmons, Leigh Ann; Bilbo, Staci D.

doi:10.1038/s42255-022-00693-8

Cited by 29 publications

(24 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maternal overnutrition was induced by allowing dams to consume an obesogenic diet prior to mating, during gestation, and throughout lactation [ 9 , 42 ]. Female C57BL/6 J mice were given ad libitum access to either LFD or HFD and standard chow for 6 weeks, at which point males were introduced ( Figure 1 A).…”

Section: Resultsmentioning

confidence: 99%

“…S1 ) are consistent with reports in which both males and females are at increased risk of developing diet-induced obesity following perinatal overnutrition [ 69 , 70 ]. Interestingly, female maternally over-nourished offspring develop increased adiposity and impaired glucose regulation [ 69 ], whereas over-nourished males may be at greater risk of developing broader hypothalamic changes and impaired reward seeking behavior [ 9 , 71 ]. Our results demonstrating pronounced HFD induced weight gain in females are consistent with this.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, elevated maternal weight is associated with increased risk of neuropsychiatric illness and metabolic dysfunction later in life [ [3] , [4] , [5] , [6] , [7] ]. This is recapitulated in animal models in which perinatal exposure to obesogenic diets leads to offspring that are predisposed to widespread phenotypic changes including those that mirror the neuropsychiatric and metabolic disorders seen in humans [ [8] , [9] , [10] , [11] , [12] ]. In rodent models, perinatal exposure to obesogenic diets causes pronounced metabolic changes later in life.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

Shrivastava¹,

Swaminathan²,

Barlotta³

et al. 2023

Molecular Metabolism

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

Shrivastava¹,

Swaminathan²,

Barlotta³

et al. 2023

Molecular Metabolism

View full text Add to dashboard Cite

“…111 Yet, the specific behavioral phenotypes that adult offspring exhibit are sex-specific: females have significantly decreased sociability scores, whereas males had diminished non-social reward behaviors, and increased escape responses. 112 Equally sexdetermined is the increased vulnerability of male offspring because of the altered epigenetic control of gene transcription in the developing brain, 113 which could limit spatial learning and memory. 114 In turn, female offspring show more pronounced stress pathobiology in adulthood, with altered gene expression seen in both the hypothalamus and amygdala.…”

Section: Sex-specific Sensitivity and Outcome Severity In Fetal Brainsmentioning

confidence: 99%

“…Changes in USVs emitted by infant offspring were also changed in both sexes, and compromised maternal pup retrieval and care behaviors in HFD dams 111 . Yet, the specific behavioral phenotypes that adult offspring exhibit are sex‐specific: females have significantly decreased sociability scores, whereas males had diminished non‐social reward behaviors, and increased escape responses 112 . Equally sex‐determined is the increased vulnerability of male offspring because of the altered epigenetic control of gene transcription in the developing brain, 113 which could limit spatial learning and memory 114 .…”

Section: Maternal Diet As a Risk Factor For Mental Disorders In Their...mentioning

confidence: 99%

Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Cinquina

Keimpema

Pollak

et al. 2023

J Neuroendocrinology

View full text Add to dashboard Cite

Obesity is a key medical challenge of our time. The increasing number of children born to overweight or obese women is alarming. During pregnancy, the circulation of the mother and her fetus interact to maintain the uninterrupted availability of essential nutrients for fetal organ development. In doing so, the mother's dietary preference determines the amount and composition of nutrients reaching the fetus. In particular, the availability of polyunsaturated fatty acids (PUFAs), chiefly their ω‐3 and ω‐6 subclasses, can change when pregnant women choose a specific diet. Here, we provide a succinct overview of PUFA biochemistry, including exchange routes between ω‐3 and ω‐6 PUFAs, the phenotypes, and probable neurodevelopmental disease associations of offspring born to mothers consuming specific PUFAs, and their mechanistic study in experimental models to typify signaling pathways, transcriptional, and epigenetic mechanisms by which PUFAs can imprint long‐lasting modifications to brain structure and function. We emphasize that the ratio, rather than the amount of individual ω‐3 or ω‐6 PUFAs, might underpin physiologically correct cellular differentiation programs, be these for neurons or glia, during pregnancy. Thereupon, the PUFA‐driven programming of the brain is contextualized for childhood obesity, metabolic, and endocrine illnesses.

show abstract

Dietary nutrients that potentially mitigate autism spectrum disorder and dietary recommendations for children and pregnant women

Li,

Kong,

Tian

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

The increasing incidence of autism spectrum disorder (ASD) worldwide poses serious social and family problems. Various risk factors for ASD are gradually being recognized, and there are also various options for the treatment of ASD. It is worth noting that dietary interventions have been shown to have a positive effect in terms of mitigating and preventing some psychiatric disorders, such as epilepsy, Parkinson's disease, and ASD, and they are gradually receiving attention as a safe adjuvant treatment. In this review, based on the current understanding of the pathogenic factors and intervention strategies for ASD, different dietary patterns that can be selected for children with ASD are discussed in depth. Moreover, a review was conducted on the use of dietary factors, such as natural products from food sources, prebiotics, and probiotics, as effective supplements to existing dietary patterns. As increasing evidence shows that maternal risk factors, such as obesity, diabetes, and hypertension, are associated with an increased risk of ASD in offspring, dietary suggestions are also made for pregnant woman with ASD‐related risk factors to counteract the impact of these risk factors. With compensation from food‐derived natural products, prebiotics, and probiotics, suitable dietary patterns can further enhance the effectiveness of dietary interventions for ASD. In addition, dietary recommendations for pregnant woman may reduce the potential impact of obesity, diabetes, and hypertension and may help to prevent the occurrence of ASD to the maximum extent possible.

show abstract

Maternal diet disrupts the placenta–brain axis in a sex-specific manner

Cited by 29 publications

References 75 publications

Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Dietary nutrients that potentially mitigate autism spectrum disorder and dietary recommendations for children and pregnant women

Contact Info

Product

Resources

About