Maternal cortisol during pregnancy is related to infant cardiac vagal control

Rash, Joshua A.; Campbell, Tavis S.; Letourneau, Nicole; Giesbrecht, Gerald F.

doi:10.1016/j.psyneuen.2015.01.024

Cited by 19 publications

(30 citation statements)

References 67 publications

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“…142,146 Fetal exposure to excess cortisol may lead to altered programming of the fetal HPA axis, which, in turn, may be associated with adverse birth outcomes and could have long-term child health consequences. 19,[142][143][144][145][146][147][148][149][150] A linear relation was shown between fetal and maternal cortisol concentrations. 151 Cortisol stimulates corticotropin-releasing hormone secretion and production, resulting in positive maternal and fetal feedback loops and increased cortisol concentrations, potentially further amplifying the effect.…”

Section: Underlying Mechanismsmentioning

confidence: 77%

Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review

Vehmeijer

Guxens

Duijts

et al. 2018

J Dev Orig Health Dis

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Maternal psychological distress is common in pregnancy and may influence the risk of adverse outcomes in children. Psychological distress may cause a suboptimal intrauterine environment leading to growth and developmental adaptations of the fetus and child. In this narrative review, we examined the influence of maternal psychological distress during pregnancy on fetal outcomes and child cardiometabolic, respiratory, atopic and neurodevelopment-related health outcomes. We discussed these findings from an epidemiological and life course perspective and provided recommendations for future studies. The literature in the field of maternal psychological distress and child health outcomes is extensive and shows that exposure to stress during pregnancy is associated with multiple adverse child health outcomes. Because maternal psychological distress is an important and potential modifiable factor during pregnancy, it should be a target for prevention strategies in order to optimize fetal and child health. Future studies should use innovative designs and strategies in order to address the issue of causality.

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Section: Underlying Mechanismsmentioning

confidence: 77%

Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review

Vehmeijer

Guxens

Duijts

et al. 2018

J Dev Orig Health Dis

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show abstract

“…Findings generally showed that PNMS was associated with variable deviations from normal development in female fetuses, whereas PNMS was associated with consistently accelerated development in males [46]. In contrast, data from the Alberta Pregnancy Outcomes & Nutrition study ( N = 194) found no evidence of sex-dependent associations when evaluating effects of both prenatal maternal cortisol and depressive symptoms on an indicator of offspring parasympathetic nervous system functioning (cardiac vagal control) at age 6 months [29]. …”

Section: Resultsmentioning

confidence: 99%

“…To further complicate matters, a number of studies have shown that PNMS x sex interactions are dependent on other factors, creating higher-order interactions. The most well-established of these factors is timing of exposure [77, 78], which was highlighted by many studies in this review [29, 36, 39, 43, 46, 49, 54, 66, 70•]. Finally, including child sex as a moderator may be insufficient: Evaluating PNMS programming may require entirely different models with different functional forms for girls and boys.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature

Sutherland

Brunwasser

2018

Curr Psychiatry Rep

117

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Most articles (k = 35) found evidence of either sex-specific associations (significant in one sex but not the other) or significant PNMSstress interactions for at least one child health outcome. Evidence for sex-dependent effects was strongest in the group of studies evaluating child neural/nervous system development and temperament as outcomes. There is sufficient evidence of sex-dependent associations to recommend that researchers always consider the potential role of child sex in PNMS programming studies and report descriptive statistics for study outcomes stratified by child biological sex.

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“…13 Similar mechanisms have been demonstrated in the case of maternal depression. 13,89 Maternal stress and cortisol levels during pregnancy impact the development of infant cardiac vagal tone, 111 which is strongly associated with children’s later abilities to regulate emotions. Higher maternal cortisol levels during pregnancy were associated with infants’ slower behavioral distress recovery and larger cortisol responses in response to a painful procedure at age 2.…”

Section: Potential Mechanisms For the Transmission Of Riskmentioning

confidence: 99%

Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model

Stone

Wilson

2016

PAIN

119

135

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Offspring of parents with chronic pain are at increased risk for pain and adverse mental and physical health outcomes (Higgins et al, 2015). Although the association between chronic pain in parents and offspring has been established, few studies have addressed why or how this relation occurs. Identifying mechanisms for the transmission of risk that leads to the development of chronic pain in offspring is important for developing preventive interventions targeted to decrease risk for chronic pain and related outcomes (eg, disability and internalizing symptoms). This review presents a conceptual model for the intergenerational transmission of chronic pain from parents to offspring with the goal of setting an agenda for future research and the development of preventive interventions. Our proposed model highlights 5 potential mechanisms for the relation between parental chronic pain and pediatric chronic pain and related adverse outcomes: (1) genetics, (2) alterations in early neurobiological development, (3) pain-specific social learning, (4), general parenting and family health, and (5) exposure to stressful environment. In addition, the model presents 3 potential moderators for the relation between parent and child chronic pain: (1) the presence of chronic pain in a second parent, (2) timing, course, and location of parental chronic pain, and (3) offspring’s characteristics (ie, sex, developmental stage, race or ethnicity, and temperament). Such a framework highlights chronic pain as inherently familial and intergenerational, opening up avenues for new models of intervention and prevention that can be family centered and include at-risk children.

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Maternal cortisol during pregnancy is related to infant cardiac vagal control

Abstract: Maternal cortisol during pregnancy was associated with infant CVC at 6-months of age. Such influences may have enduring impacts on the child and important implications for the development of physical and mental health outcomes.

Cited by 19 publications

References 67 publications

Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review

Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review

Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature

Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model

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