Maternal Contributions to Preterm Delivery

Boyd, Heather A.; Poulsen, Gry; Wohlfahrt, Jan; Murray, Jeffrey C.; Feenstra, Bjarke; Melbye, Mads

doi:10.1093/aje/kwp324

Cited by 139 publications

(134 citation statements)

References 38 publications

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“…A history of a prior spontaneous PTB increases the risk for subsequent PTBs in the same mother (11). Moreover, epidemiological analyses of large, population-based cohorts have revealed increased risk of PTB if the mother herself was born preterm or has sisters that have had preterm children (12). These observations point to the existence of genetic contributors to PTB through the maternal lineage.…”

Section: Established Pathways Implicated In Term and Preterm Parturitionmentioning

confidence: 99%

Prevention of preterm birth: Harnessing science to address the global epidemic

et al. 2014

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Section: Established Pathways Implicated In Term and Preterm Parturitionmentioning

confidence: 99%

Prevention of preterm birth: Harnessing science to address the global epidemic

et al. 2014

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“…Preterm delivery, defined as spontaneous or medically induced delivery before gestational week 37, is the major cause of perinatal mortality and morbidity and is an important risk factor of long-term physical and mental disabilities (66)(67)(68)(69)(70). The aetiology of spontaneous preterm delivery is poorly understood but, as for other pregnancy outcomes, studies have indicated associations between maternal diet and the risk of preterm delivery.…”

Section: Maternal Diet and Preterm Deliverymentioning

confidence: 99%

Diet matters, particularly in pregnancy – Results from MoBa studies of maternal diet and pregnancy outcomes

Brantsæter¹,

Haugen²,

Myhre³

et al. 2014

Nor J Epidemiol

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Awareness that maternal diet may influence the outcome of pregnancy as well as the long-term health of mother and child has increased in recent years. A new food frequency questionnaire (FFQ) was developed and validated specifically for the Norwegian Mother and Child Cohort Study (MoBa). The MoBa FFQ is a semi-quantitative tool which covers the average intake of food, beverages and dietary supplements during the first 4 to 5 months of pregnancy. It includes questions about intakes of 255 foods and dishes and was used from 2002 onwards. Data assessed by the MoBa FFQ is available for 87,700 pregnancies. Numerous sub-studies have examined associations between dietary factors and health outcomes in MoBa. The aim of this paper is to summarize the results from 19 studies of maternal diet and pregnancy outcomes, which is the complete collection of studies based on the MoBa FFQ and published before September 2014. The overall research question is whether maternal diet -from single substances to dietary patterns -matters for pregnancy outcome. The pregnancy outcomes studied till now include birth size measures, infants being small and large for gestational age, pregnancy duration, preterm delivery, preeclampsia, as well as maternal gestational weight gain and postpartum weight retention. As a whole, the results from these studies corroborate that the current dietary recommendations to pregnant women are sound and that maternal diet during pregnancy is likely to contribute to reduce the risk of pregnancy complications including preterm birth, preeclampsia, and reduced foetal growth. The results provide supporting evidence for recommending pregnant women to consume vegetables, fruit, whole grain, fish, dairy, and water regularly and lower the intake of sugar sweetened beverages, processed meat products and salty snacks. The results showing negative impact of even low levels of environmental contaminants support the precautionary advice on consumption of foods containing these. New findings are that particularly lean fish explained the positive association between seafood intake and foetal growth, and the indications of a protective effect of probiotic and antimicrobial foods on pregnancy outcomes. This points to the importance of diet composition for a healthy gut flora and the body's immune response. Although these studies are observational and cannot infer causality, the results identify diet as an important modifiable lifestyle factor, suggesting that healthy eating, defined as following the official recommendations, is particularly important in pregnancy.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Genetic predisposition for PTB [4][5][6] has been hypothesized based upon: 1) demonstration of familial aggregation; [7][8][9][10][11] 2) measures of heritability; [11][12][13][14][15] 3) identification of diseasesusceptibility genes; and 4) racial disparity in preterm birth rate [16][17][18][19] that may be related to frequency differences in risk predisposing alleles. [20][21][22][23][24] Familial aggregation, defined as the co-occurrence of a trait in members of a family that can not be readily accounted for by chance, has been demonstrated for PTB.…”

Section: Introductionmentioning

confidence: 99%

14: Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes

Romero¹,

Velez²,

Mazaki‐Tovi³

et al. 2009

American Journal of Obstetrics and Gynecology

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Objective-To determine whether maternal/fetal SNPs in candidate genes are associated with spontaneous preterm labor/delivery. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptStudy Design-A genetic association study was conducted in 223 mothers and 179 fetuses [preterm labor with intact membranes who delivered <37 weeks (PTB)], and 599 mothers and 628 fetuses (normal pregnancy): 190 candidate genes and 775 SNPs were studied. Single locus/ haplotype association analyses were performed; FDR was used to correct for multiple testing (q*=0.15)]. Results-1)The strongest single locus associations with PTB were IL6R (fetus: p=0.000148) and TIMP2 (mother: p=0.000197), remaining significant after correction for multiple comparisons; 2) Global haplotype analysis indicated an association between a fetal DNA variant in IGF2 and maternal COL4A3 (global p=0.004 and 0.007, respectively).Conclusion-A SNP involved in controlling fetal inflammation (IL6R) and DNA variants in maternal genes encoding for proteins involved in extracellular matrix biology approximately doubled the risk of PTB.

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Maternal Contributions to Preterm Delivery

Cited by 139 publications

References 38 publications

Prevention of preterm birth: Harnessing science to address the global epidemic

Prevention of preterm birth: Harnessing science to address the global epidemic

Diet matters, particularly in pregnancy – Results from MoBa studies of maternal diet and pregnancy outcomes

14: Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes

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