Maternal contamination with PCBs and reproductive outcomes in an Australian population

Khanjani, Narges; Sim, Malcolm Ross

doi:10.1038/sj.jes.7500495

Cited by 34 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies have found no relationship between maternal exposure to halogenated organics and birth weight or gestational age (Longnecker et al, 2005;Khanjani and Sim, 2006). We did not observe a consistent association between maternal exposure to PBB and infant birth weight or gestational age in this cohort.…”

Section: Discussioncontrasting

confidence: 53%

Maternal exposure to polybrominated and polychlorinated biphenyls: Infant birth weight and gestational age

Givens¹,

Small²,

Terrell³

et al. 2007

Chemosphere

View full text Add to dashboard Cite

Understanding the influence of maternal exposures on gestational age and birth weight is essential given that pre-term and/or low birth weight infants are at risk for increased mortality and morbidity. We performed a retrospective analysis of a cohort exposed to polybrominated biphenyls (PBB) through accidental contamination of cattle feed and polychlorinated biphenyls (PCB) through residual contamination in the geographic region. Our study population consisted of 444 mothers and their 899 infants born between 1975 and 1997. Using restricted maximum likelihood estimation, no significant association was found between estimated maternal serum PBB at conception or enrollment PCB levels and gestational age or infant birth weight in unadjusted models or in models that adjusted for maternal age, smoking, parity, infant gender, and decade of birth. For enrollment maternal serum PBB, no association was observed for gestational age. However, a negative association with high levels of enrollment maternal serum PBB and birth weight was suggested. We also examined the birth weight and gestational age among offspring of women with the highest (10%) PBB or PCB exposure, and observed no significant association. Because brominated compounds are currently used in consumer products and therefore, are increasingly prevalent in the environment, additional research is needed to better understand the potential relationship between in utero exposure to brominated compounds and adverse health outcomes.

show abstract

Section: Discussioncontrasting

confidence: 53%

Maternal exposure to polybrominated and polychlorinated biphenyls: Infant birth weight and gestational age

Givens¹,

Small²,

Terrell³

et al. 2007

Chemosphere

View full text Add to dashboard Cite

show abstract

“…In accordance with our results, a previous study also found tendencies towards increased secondary sex ratio at higher maternal PCB exposure, although these findings were not statistically significant [43]. Accordingly, a recent review concluded that there is no convincing evidence of an association between ΣPCB and secondary sex ratio [44], although some of the studies included in the review did report a significantly decreased sex ratio at increased PCB exposure [5,6].…”

Section: Discussionsupporting

confidence: 88%

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Timmermann¹,

Choi

Petersen

et al. 2017

International Journal of Circumpolar Health

View full text Add to dashboard Cite

This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother–child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p’-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0–16%), 7% (95% CI = 0–14%) and 9% (95% CI = 2–17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention.

show abstract

“…Related human/clinical work examines a host of social behaviors in different settings such as the home or school environment [30,31]. Other social-related research has focused on the effects of PCBs on reproductive behavior and fertility [32,33]. One of the recent reports on social behavior described the effects of PCBs on social play interactions in children in a Dutch cohort [34].…”

Section: Introductionmentioning

confidence: 99%

Effects of polychlorinated biphenyls on maternal odor conditioning in rat pups

Cromwell

Johnson

McKnight

et al. 2007

Physiology & Behavior

View full text Add to dashboard Cite

Polychlorinated biphenyls (PCBs) are pervasive environmental contaminants that can have damaging effects on physiologic, motoric and cognitive function. Results from studies on PCBs and behavior have shown that exposure can alter learning and memory processes and that these shifts in cognitive abilities can be related to changes in hormonal and neural function. Little experimentation has been done on the impact of exposure to PCBs on social and emotional development. Previous work has shown that exposure to PCBs in children can alter play behavior. Importantly, exposure to PCBs has been found to change aspects of maternal-offspring interactions in rodents. The present study examined the impact of PCBs on maternal odor conditioning in rat pups 12-14 days of age. A modified version of the conditioned place preference paradigm was used that incorporated a maternal-associated odor cue (lemon scent) as the conditioned stimulus. PCBs significantly depressed the preference for the maternal-associated cue but did not impair discrimination for a novel odor. These effects could arise due to changes in the social dynamics between the dam and offspring after co-exposure to PCBs. For example, dams exposed to PCBs during gestation have been found to show elevated grooming directed towards pups exposed to PCBs. This change in maternal care can have dramatic effects on behavioral and hormonal systems in the developing rat pup. In conclusion, perinatal PCBs alter important social behaviors of both the mother and pup, and these alterations could have long-lasting effects on behavioral, cognitive and emotional development.

show abstract

Maternal contamination with PCBs and reproductive outcomes in an Australian population

Cited by 34 publications

References 27 publications

Maternal exposure to polybrominated and polychlorinated biphenyls: Infant birth weight and gestational age

Maternal exposure to polybrominated and polychlorinated biphenyls: Infant birth weight and gestational age

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Effects of polychlorinated biphenyls on maternal odor conditioning in rat pups

Contact Info

Product

Resources

About