Maternal complications following amniocentesis and chorionic villus sampling for prenatal karyotyping

Abstract

aObjective To investigate whether amniocentesis and chorionic villus sampling increase the risk of bleeding, placental abruption, complications related to amniotic cavity and membranes, abnormal labour, operative deliveries and to investigate the impact of gestational length at the time of the procedure. Design A population-based cohort study.Setting Sweden, 1991Sweden, -1996

Septic Shock in Obstetrics and Gynecology

“…Intrauterine infection is a rare event after invasive prenatal diagnostic procedures 60 . According to data from large studies, the incidence of chorioamnionitis is 5 per 1,000 cases after CVS; 3.7 per 1,000 cases after amniocentesis; and 8.8 per 1000 cases after cordocentesis, compared with 3 per 1,000 cases in non-exposed women 61,62 . Infection is usually mild to moderate.…”

Invasive Prenatal Diagnosis

“…Additionally, speaking of safety, the Cochrane review showed that the transcervical CVS is more technically demanding than transabdominal CVS with more failures to obtain sample and more multiple insertions (Alfirevic et al,2003). There are no differences in birth weight , gestational age at delivery, or congenital malformations with either method (Cederholm et al,2003). Because of the specificity of the sampling route, transabdominal and transcervical sampling techniques are expected to have different types of contraindications.…”

“…However, there is some concern about the role of less serious infection in women who experience fetal loss after transcervical CVS. Because transcervical CVS involves passage of a cannula or forceps through the cervical canal from the perineum and vagina, microbial colonization and infection, with consequent morbidity for both mother and fetus, may result (Cederholm et al,2003).…”

“…Amniocentesis is not associated with severe pregnancy complications such as placental abruption or placenta praevia. On the other hand after amniocentesis there is an increased risk of complications related to amniotic cavity, membranes and hypotonic uterine dysfunction (Cederholm et al,2003).Feto-maternal hemorrhage occurs during amniocentesis in one out of six women, and may therefore theoretically give rise to subsequent isoimmunisation. In a prospective cohort study (Tabor et al,1987) the immunization rate was 1.4%.…”

Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre‐eclampsia

“…We have previously reported a lower normal delivery rate after prenatal invasive testing, but no increase in preterm delivery or severe pregnancy complications such as abruption or placenta praevia were identified. 2,3 The aim of this population-based cohort study, including non-exposed controls, was to estimate the risk of maternal hypertensive complications in later gestations after first-and second-trimester prenatal invasive diagnostic procedures, AC and CVS.…”