Maternal coconut oil intake on lactation programs for endocannabinoid system dysfunction in adult offspring

“…The tonus of the ECS in the brain and peripheral tissues may be modulated by unappropriated parental life style and environmental conditions (nutrition, toxicant exposure, and stress) during the perinatal period and adolescence, predisposing offspring to metabolic and behavioral disorders throughout life (Figure 6; Lopez-Gallardo et al, 2012;Stringer et al, 2013;Ramirez-Lopez et al, 2015, 2016aRomano-Lopez et al, 2016;Almeida et al, 2017Almeida et al, , 2019Almeida et al, , 2020Dias-Rocha et al, 2018;Gandhi et al, 2018;Miranda et al, 2018;de Oliveira et al, 2019;Soares et al, 2019;Rivera et al, 2020). This phenomenon is known as "metabolic programming" or "ontogenetic plasticity" and involves epigenetic regulation of gene expression (Brenseke et al, 2013;Lillycrop and Burdge, 2015;Gluckman et al, 2019).…”

Section: Programming Of the Endocannabinoid System During Early Lifementioning

confidence: 99%

“…In contrast, the investigation of the ECS components in subcutaneous adipose tissue before and after weight loss in obese patients showed no effect on tissue levels of AEA and increased expression of Faah mRNA (Bennetzen et al, 2011). In a randomized controlled trial, healthy subjects underwent a 12-week moderate aerobic exercise program for weight loss and showed reduced levels of AEA which was associated with improvement in mood and anger (Belitardo de Oliveira et al, 2019). Polymorphisms of the Faah gene have been associated with metabolic benefits after weight loss induced by a 3-month dietary intervention with a high-PUFA diet in obese subjects, such as a decrease in insulin resistance and leptinemia (de Luis et al, 2013), evidencing the important role of the endocannabinoid metabolism in metabolic health.…”

Section: Endocannabinoid System and Weight Lossmentioning

confidence: 99%

Quality of Life and a Surveillant Endocannabinoid System

et al. 2021

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The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is a major player in the hypothalamic-peripheral system-adipose tissue in the regulation of food intake, energy storage, nutritional status, and adipose tissue mass, consequently affecting obesity. Loss of ECS control might affect mood disorders (anxiety, hyperactivity, psychosis, and depression), lead to drug abuse, and impact neurodegenerative (Alzheimer’s, Parkinson, Huntington, Multiple, and Amyotrophic Lateral Sclerosis) and neurodevelopmental (autism spectrum) disorders. Practice of regular physical and/or mind-body mindfulness and meditative activities have been shown to modulate endocannabinoid (eCB) levels, in addition to other players as brain-derived neurotrophic factor (BDNF). ECS is involved in pain, inflammation, metabolic and cardiovascular dysfunctions, general immune responses (asthma, allergy, and arthritis) and tumor expansion, both/either in the brain and/or in the periphery. The reason for such a vast impact is the fact that arachidonic acid, a precursor of eCBs, is present in every membrane cell of the body and on demand eCBs synthesis is regulated by electrical activity and calcium shifts. Novel lipid (lipoxins and resolvins) or peptide (hemopressin) players of the ECS also operate as regulators of physiological allostasis. Indeed, the presence of cannabinoid receptors in intracellular organelles as mitochondria or lysosomes, or in nuclear targets as PPARγ might impact energy consumption, metabolism and cell death. To live a better life implies in a vigilant ECS, through healthy diet selection (based on a balanced omega-3 and -6 polyunsaturated fatty acids), weekly exercises and meditation therapy, all of which regulating eCBs levels, surrounded by a constructive social network. Cannabidiol, a diet supplement has been a major player with anti-inflammatory, anxiolytic, antidepressant, and antioxidant activities. Cognitive challenges and emotional intelligence might strengthen the ECS, which is built on a variety of synapses that modify human behavior. As therapeutically concerned, the ECS is essential for maintaining homeostasis and cannabinoids are promising tools to control innumerous targets.

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“…As of the year 2018, the total world production of coconut was 250-300 million tonnes" [13]. "Every part of the coconut plant is useful with a wide range of products being obtained from it" [14][15][16][17]. "Fresh coconut fruit is appreciated for its juice, food, and animal feed; coconut husks are used as raw material supply [18][19][20][21][22][23] and for wall hangings; fibers are used for clothing and bags, among other uses" [24].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Charcoal Briquettes Fuel from a Blend of Coconut Husk and Corncob

Yirijor

Adazabra²,

McBagonluri

2023

JENRR

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Energy is very essential to human livelihood and makes significant help to economic, social, and environmental features of human development. Biomass is certainly a very significant source of renewable energy worldwide and abundant with high energy potential. This research aimed to characterize and produce briquette fuel from the combination of coconut husk and corncob using starch as a binder. The composite briquettes were produced by varying the mixture ratio of coconut husk to corncob (CH: CC), 80:20, 60:40, 50:50, 40:60, 20:80 using starch as a binding agent. The physical and combustion characteristics were analyzed according to the America Society of Testing of Materials Standard. It was observed that the moisture content decreased from 5.02% to 4.88%, fixed carbon increased from 74.20% to 75.13%, volatile matter increased from 20.20% to 21.70%, Ash content decreased from 5.60% to 3.17% and the calorific value increased from 20.35 MJ/kg to 26.75 MJ/kg. The findings also show that the maximum density and durability indexes were 839 kg/m3 and 98.58%. The briquette at the ratio 20:80 of coconut husk to corncob has the highest calorific value and implies that it has more heating advantages and will therefore be suitable as an alternative solid fuel.

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Maternal coconut oil intake on lactation programs for endocannabinoid system dysfunction in adult offspring

Cited by 6 publications

References 54 publications

Citrate enrichment in a Western diet reduces weight gain via browning of adipose tissues without resolving diet-induced insulin resistance in mice

Citrate enrichment in a Western diet reduces weight gain via browning of adipose tissues without resolving diet-induced insulin resistance in mice

Quality of Life and a Surveillant Endocannabinoid System

Fabrication and Characterization of Charcoal Briquettes Fuel from a Blend of Coconut Husk and Corncob

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