Maternal cocaine abuse – An evidence review

Fraser, Alyssa; Walker, Karen; Green, Janet

doi:10.1016/j.jnn.2015.09.002

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Multiple logistic regression analyses were undertaken in 840 trios of parent-child assessing the association of paternal opioid consumption with offspring BMI and the plasma lipid components (triglyceride, cholesterol and HDL). Despite the high rate of substance use among parents and its burden on public health care, epidemiological studies have mainly focused on the offspring neonatal withdrawal syndrome and short-term effects in the offspring, or are mainly limited to the psychological and neurological symptoms 12,15,[26][27][28] . However, evidences so far support the notion that parental substance use (cocaine and alcohol) may exert long effects on offspring metabolism modifying the risk of adult-onset disease such as diabetes 9 .…”

Section: Discussionmentioning

confidence: 99%

Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profile

Jalali

Bahrampour

Khalili

et al. 2021

Sci Rep

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A growing body of evidence suggests that opioid use may affect consumer’s offspring by second-hand passive smoke exposure, as well as by transgenerational impacts mediated by genetic and epigenetic alterations of paternal gametes. In human studies, these effects are limited to investigating the neural, behavioral and cognitive characteristics of offspring. Only animal studies have investigated the metabolic parameters influenced by passive opium smoke exposure. Here, we conducted population-based analyses aimed to estimate the association of paternal opioid consumption, started before or after child birth, with BMI status and plasma lipid profile of young adult offspring. The present study includes 840 parents-offspring trios (offspring aged 15–35, parents aged 35–70) who participated in the prospective Rafsanjan Cohort Study (RCS)—a city in the south-east of Iran—as one of the district areas of the PERSIAN cohort (Prospective Epidemiological Research Studies in IrAN). All procedures for interviews, anthropometric measurements and physical examinations, biological sample collection and laboratory tests for blood biochemical parameters were conducted according to the PERSIAN cohort protocol, and in the well-established RCS setting. Crude and adjusted multiple logistic regression analysis were conducted to assess the relationship of paternal regular opioid use with offspring’s BMI status, and plasma lipid factors. The prevalence of fathers who use opioids regularly among the studied trios was 42.8% (360/840). Our regression analyses demonstrated that paternal opioid use started pre-fatherhood is associated with 76% higher adjusted odds ratio (OR) of overweight/obesity in young offspring (adjusted OR 1.76 (95% CI 1.15–2.71)), adjusting for sex, age, parental BMIs, paternal smoking status and socioeconomic status index (WSI). This relationship persisted when fathers who used opioid by routes other than inhaling (oral) were excluded from logistic analysis (adjusted OR 1.73 (95% CI 1.12–2.68)). Interestingly, sex stratified analysis displayed a 201% increased odds ratio of overweight/obesity in sons of fathers who use opioid regularly, started after child birth (Adjusted OR 3.01 (95% CI 1.68–5.39), while no significant association was found in daughters (adjusted OR 0.74 (95% CI 0.35–1.54)). Additionally, increasing exposure–response relationships were observed between odds ratios of overweight/obesity and the number of years of paternal opioid use after birth (p-trend = 0.0008). Paternal regular opioid use started pre-fatherhood was associated with 54% lowered risk of underweight [adjusted OR 0.46 (95% CI 0.24–0.86)]. Finally, paternal opioid consumption started either before or after child birth did not show a significant association with the high level of the three parameters of plasma lipid factors (triglyceride, cholesterol and HDL-cholesterol) in offspring. Our results suggest that the environmental impacts of paternal regular opioid use may be sufficient to make an effect on male offspring metabolism independent of genetic and epigenetic impact on gametes.

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Section: Discussionmentioning

confidence: 99%

Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profile

Jalali

Bahrampour

Khalili

et al. 2021

Sci Rep

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Preterm Infant with Bruising and Discoloration of Upper Extremity after Birth

Stadd,

Gall,

Kochan

2023

NeoReviews

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Investigation of Some Modifiable Risk Factors That Lead to Congenital Anomalies: A Review Article

Abdi¹,

Mehrvar²,

Valizadeh³

et al. 2020

WJPN

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Background: Congenital anomalies are inborn errors of development. Genetic and environmental factors are known causes of congenital anomalies. Environmental factors are modifiable risk factors. This review focuses on modifiable risk factors for birth defects. There is a strong link between alcohol use and an increased risk of congenital anomalies. Marijuana can be expected to cause fetal growth restriction; smoking before conception, even with cessation in the first trimester, may also pose a risk for gastroschisis. Benzodiazepines during the first trimester were associated with Dandy–Walker malformation ,anophthalmia or microphthalmia and esophageal atresia. While oral retinoids are absolutely contraindicated, topical retinoids, should conservatively be avoided during pregnancy but if were used by accident, the existing data can reduce the anxiety of happening adverse pregnancy outcomes. Antihypertensives such as labetalol, methyldopa and extended release nifedipine are relatively safe choices. Antiemeticssuch as doxylamine-pyridoxine and metoclopramide may have potential teratogenicity in first trimester. Ondansetron use was not significantly associated with major congenital anomalies but recent meta-analysis suggested more concern. An antiepileptic such as valproate poses the highest risk among antiepileptic drugs, whereas the prevalence of congenital anomalies is the lowest with lamotrigine, levetiracetam, and oxcarbazepine. Education and counseling to women who are planning to become pregnant can reduce the risk of congenital anolamies.

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Maternal cocaine abuse – An evidence review

Cited by 3 publications

References 15 publications

Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profile

Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profile

Preterm Infant with Bruising and Discoloration of Upper Extremity after Birth

Investigation of Some Modifiable Risk Factors That Lead to Congenital Anomalies: A Review Article

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