Maternal cigarette smoking: The effects on umbilical and uterine blood flow velocity

Morrow, Robert J.; Ritchie, J. W. K.; Bull, Shelley B.

doi:10.1016/0002-9378(88)90415-2

Cited by 132 publications

(54 citation statements)

References 13 publications

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“…A likely explanation is relative fetal hypoxia, but the mechanisms that may be involved are multiple. In theory, there may be nicotineinduced placental vasoconstriction, 25 decreased fetal tissue oxygenation attributable to production of fetal carboxyhemoglobin, and placental vascular disease. 26 Other indicators of fetal hypoxia during maternal smoking include fetal growth restriction, 2 increased risk of spontaneous abortion, 1 and neurodevelopmental anomalies 1 that occur more frequently among infants of smoking mothers.…”

Section: Discussionmentioning

confidence: 99%

Effect of Passive Smoking in Pregnancy on Neonatal Nucleated Red Blood Cells

Dollberg¹,

Fainaru

Mimouni³

et al. 2000

Pediatrics

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ABSTRACT. Objective. We evaluated whether the absolute nucleated red blood cell (RBC) count is elevated in term, appropriate for gestational age (AGA) infants born to women exposed to passive smoking in pregnancy.Patients and Methods. We compared absolute nucleated RBC counts taken during the first 12 hours of life in 2 groups of term, vaginally delivered infants, 1 group born to mothers who were routinely exposed to tobacco smoke during pregnancy (n ‫؍‬ 55) either at home or at the workplace, and the other to mothers who were not routinely exposed to any tobacco smoke (n ‫؍‬ 31). We excluded infants of women with conditions known to elevate nucleated RBC counts.Results. There were no differences between groups in birth weight, maternal age, gravidity, parity, maternal analgesia during labor, 1-and 5-minute Apgar scores. Gestational age was minimally higher in the control group (39.6 ؎ 1.1 vs 39.2 ؎ .8 weeks). The median absolute nucleated RBC count in the passive smoking group was 357 ؋ 10 6 /L (range: 0 -5091 ؋ 10 6 /L) versus 237 ؋ 10 6 /L (range: 0 -1733 ؋ 10 6 /L) in nonsmoking controls. Stepwise regression analysis that included Apgar scores, gestational age, and the passive smoking status (yes/no) as independent variables showed significant correlation of absolute nucleated RBC count only with the passive smoking status.Conclusion. At birth, term AGA infants born to mothers exposed to passive smoking have increased circulating absolute nucleated RBC counts compared with those of controls. We speculate that passive smoking in pregnancy should be avoided, because it may have subtle negative effects on fetal oxygenation. Pediatrics 2000; 106(3). URL: http://www.pediatrics.org/cgi/content/full/ 106/3/e34; tobacco, passive smoking, term infants, nucleated red blood cells.

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Section: Discussionmentioning

confidence: 99%

Effect of Passive Smoking in Pregnancy on Neonatal Nucleated Red Blood Cells

Dollberg¹,

Fainaru

Mimouni³

et al. 2000

Pediatrics

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“…Prenatal Doppler studies [10,14] have demonstrated an acute increase in fetal blood flow velocities associated with elevated maternal BP and heart rate as well as an increase in fetal heart rate immediately after maternal smoking. We do not believe that the differences in CBFVs observed in our study between infants of smoking mothers and controls can be explained by such acute effects of nicotine, catecholamines [17], or carbon monoxide [11], for both nicotine and carbon monoxide have a half-life too short to explain a prolonged influence in infants 20 h or more after birth.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, prenatal exposure to tobacco smoke has been shown to be related to sudden infant death [4,5] and to impaired mental development [15,19,20]. Maternal smoking has been demonstrated to increase fetal blood flow velocities in the descending thoracic aorta and in umbilical vessels [10,14]. Ahlsten et al [1] showed an impaired vascular reactivity of the skin in newborn infants of smoking mothers 24-48 h after birth.…”

Section: Introductionmentioning

confidence: 99%

Increased cerebral blood flow velocities in newborn infants of smoking mothers

et al. 1993

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Abstract. Cerebral blood flow velocities (CBFV) weremeasured by the pulsed Doppler method in 41 infants of smoking mothers and in 59 apparently healthy control infants. Although gestational age, birth weight, and systolic blood pressure were lower in infants exposed to tobacco smoke prenatally, systolic (65 + 11 vs. 47 + 12cm/s, mean_+SD; P<0.001), mean (36+6 vs. 25+6cm/s; P< 0.001), and diastolic (17 + 4 vs 13 + 4cm/s; P < 0.001) CBFVs in the anterior cerebral artery were significantly higher when compared to control infants. Similar differences were seen in the internal carotid and in the basilar arteries. Multiple regression analysis did not reveal differences .other than maternal smoking to explain these observations. We conclude that prenatal tobacco smoke exposure is related to increased CBFVs in newborn infants. Further studies should determine whether this relation is not only statistical but causal and whether increased CBFVs are an indicator of prolonged effects of prenatal tobacco smoke exposure.

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“…O monóxido de carbono apresenta uma alta afinidade pela hemoglobina do feto, impedindo que esta se ligue ao oxigênio, favorecendo a hipoxemia fetal. A nicotina reduz a síntese de prostaciclinas, determinando vasoconstrição e o aumento da resistência vascular (Ylikorkalo et al, 1985;Morrow et al, 1988). Além disso, a placenta de mães tabagistas apresenta características sugestivas de hipoperfusão, e, como conseqüência, há uma maior incidência de retardo do crescimento intra-uterino, descolamento prematuro de placenta e rotura prematura das membranas ovulares (Naeye, 1980).…”

Section: Tabacounclassified

Drogas de abuso e gravidez

Yamaguchi¹,

Cardoso²,

Torres³

et al. 2008

Rev. psiquiatr. clín.

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ResumoContexto: Embora seja um problema crescente na população mundial, existem poucos trabalhos publicados sobre o uso de drogas durante a gravidez. Objetivos: Abordar de maneira objetiva as drogas de abuso (álcool, cocaína, maconha e tabaco) mais comumente utilizadas pelas mulheres em idade reprodutiva. Métodos: Foi realizada revisão bibliográfica (MEDLINE, LILACS) dos textos mais recentes abordando o uso de drogas de abuso em mulheres em idade reprodutiva. Resultados: Foram descritas as principais conseqüências da utilização de drogas de abuso, tanto para a mãe quanto para o bebê. Conclusões: Trata-se de um problema de saúde pública pouco discutido, devendo envolver uma equipe multidisciplinar em sua abordagem. A publicação de mais trabalhos se faz necessária, a fim de se estabelecer a melhor estratégia de intervenção nesta população.Yamaguchi, E.T. et al. / Rev. Psiq. Clín 35, supl 1; 44-47, 2008 Palavras-chave: Gravidez, drogas, álcool, cocaína, maconha, tabaco. AbstractBackground: Despite the fact that it has being a growing problem worldwide, very few works and papers have been published on drug use during pregnancy. Objectives: To objectively address the most commonly abused drugs (alcohol, cocaine, marijuana, and tobacco) by women of a reproductive age. Methods: A literature review (MEDLINE, LILACS) of the most recent papers on drug abuse by women of reproductive age was carried out. Results: The primary consequences of drug abuse both for the mother and the infant are described. Conclusions: This is a little discussed major public health issue which requires the involvement of a multidisciplinary team. The publication of a greater number of papers on the problem is necessary in order to establish the best strategy for addressing intervention in this population.

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Maternal cigarette smoking: The effects on umbilical and uterine blood flow velocity

Cited by 132 publications

References 13 publications

Effect of Passive Smoking in Pregnancy on Neonatal Nucleated Red Blood Cells

Effect of Passive Smoking in Pregnancy on Neonatal Nucleated Red Blood Cells

Increased cerebral blood flow velocities in newborn infants of smoking mothers

Drogas de abuso e gravidez

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