Maternal Cigarette Smoking, Metabolic Gene Polymorphism, and Infant Birth Weight

Abstract

In our study, maternal CYP1A1 and GSTT1 genotypes modified the association between maternal cigarette smoking and infant birth weight, suggesting an interaction between metabolic genes and cigarette smoking.

Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns

“…There was no modifying effect on birth weight among mothers exposed to household air pollution from cooking fires. In contrast to our study, Wang et al found a modifying effect of the maternal GSTT1-null genotype on the relationship between active tobacco smoking during pregnancy and low birth weight among a multi-ethnic sample of 741 maternal-infant pairs in urban United States [17]. Continuous maternal smoking during pregnancy was associated with a mean reduction of 377 grams in birth weight compared to birth weight of infants to mothers who never smoked (p<0.001).…”

Mental Disorders and Nicotine Dependence Among Pregnant Women in the United States

“…31,32 Our study indicates that one of every five (21.7%) pregnant women use cigarettes, and approximately one of every 10 pregnant women (12.4%) are nicotine dependent in the United States. These results are consistent with previous reports, such as a study done by Wang et al 2 showing that approximately one of every 10 (13.2%) women used cigarettes while pregnant in the United States in 1997. In addition, our study provides detailed information in terms of the distribution of these behaviors across demographic groups in the United States population, as well as new data on prevalence of nicotine dependence among pregnant women.…”

Hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), maternal smoking and size at birth

“…Smoking is a strong and independent predictor of birth weight [56, 57]. In our sample, smoking is associated with a 130 g (95% CI: 233, 27) decrease in adjusted mean birth weight, which is consistent with previous studies [58].…”