Maternal cigarette smoking during pregnancy is associated with downregulation ofmiR-16,miR-21, andmiR-146ain the placenta

Maccani, Matthew A.; Avissar-Whiting, Michele; Banister, Carolyn E.; McGonnigal, Bethany; Padbury, Jamés F.; Marsit, Carmen J.

doi:10.4161/epi.5.7.12762

Cited by 192 publications

(176 citation statements)

References 48 publications

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“…[32][33][34][35] Furthermore, smokers have been shown to exhibit altered spermatozoal mRNA profiles compared with non-smokers, and miRNA changes have been observed in the placenta of human smokers vs. non-smokers. 36,37 It is therefore possible that cigarette smoke could also induce changes in the miRNA profiles of human spermatozoa, leading to altered phenotypes that could be transmitted to future generations through the male germ line. Thus, the objectives of this study were to determine if smokers show differential spermatozoal miRNA expression compared with non-smokers, and to identify the likely pathways affected by any altered microRNAs.…”

mentioning

confidence: 99%

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

et al. 2012

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mentioning

confidence: 99%

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

et al. 2012

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“…Human/ cohort study Association between maternal smoking and placental and cord blood methylation [103,[254][255][256][257]261] Fetal growth restriction Rat Association between maternal nicotine exposure and asthma [258] Increased asthma risk in F2 offsprings…”

Section: Hypomethylation Of the Pancreatic Il13ra2 Genementioning

confidence: 99%

“…In addition to its long term epigenetic effects, maternal and paternal history have been associated with extensive placental and cord blood DNA methylation changes that are thought to mediate some of the harmful multigenerational effects of smoking (Table 2). [103,[253][254][255][256][257][258][259][260][261] However, the most compelling evidence for the contribution of smoking to epigenetic modulation of disease risk is that from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort in which fathers who had started smoking around the prepubertal age of 11 had male offsprings with significantly higher BMIs by age 9. The implication is that these obese boys were at increased risk of adult obesity and other obesity-associated health problems including many NCCDs due to lifestyle choices of their parents.…”

Section: Smoking Alcohol Pollutants and Other Environmental Chemicalsmentioning

confidence: 99%

The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease

Imam

Ismail

2017

Global Challenges

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There are already extensive reviews on the global burden of NCCDs in the public domain. [1][2][3][4][5][6] The consensus that can be surmised from the available data on NCCDs is that their overall prevalence appears to be rising globally and the projections indicate an upward trend. Epidemiological transition data suggests that the morbidity and mortality rate from these diseases is far more than that of communicable diseases in the developed world [7] and a similar trend is now occurring in the low to medium income countries (LMICs). [8] Among the NCCDs, cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality, followed closely by metabolic diseases like Noncommunicable chronic diseases (NCCDs) are the leading causes of morbidity and mortality globally. The mismatch between present day diets and ancestral genome is suggested to contribute to the NCCDs burden, which is promoted by traditional risk factors like unhealthy diets, physical inactivity, alcohol and tobacco. However, epigenetic evidence now suggests that cumulatively inherited epigenetic modifications may have made humans more prone to the effects of present day lifestyle factors. Perinatal starvation was widespread in the 19th century. This together with more recent events like increasing consumption of western and low fiber diets, smoking, harmful use of alcohol, physical inactivity, and environmental pollutants may have programed the human epigenome for higher NCCDs risk. In this review, on the basis of available epigenetic data it is hypothesized that transgenerational effects of lifestyle factors may be contributing to the current global burden of NCCDs. Thus, there is a need to reconsider prevention strategies so that the subsequent generations will not have to pay for our sins and those of our ancestors. Cardiovascular DiseasesDr. M. U. Imam

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“…In a cohort of 3000 African American women, alcohol and cocaine use was found to be associated with extreme preterm birth [125]. Of particular concern, a study by O'Leary et al [127], found that moderate ingestion of alcohol consumption (only during the first trimester of pregnancy) was associated with pre-term birth In Australia, the high rate of preterm birth in the Indigenous community is thought to be attributed to high rates of tobacco, alcohol and drug use in pregnant women [130].…”

Section: Maternal Lifestylementioning

confidence: 99%

“…Maternal behaviours such as smoking, high alcohol consumption, and ingesting illicit drugs have all been recognised as contributors to the risk of IUGR and premature birth [123][124][125][126][127]. Cigarette smoking has been reported to increase the risk of premature rupture of the membranes, pregnancy bleeding and pre-term labour.…”

Section: Maternal Lifestylementioning

confidence: 99%

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

Ryan¹,

Black²

2015

J Neonatal Biol

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Preterm birth (defined as birth prior to 37 completed weeks of gestation), occurs in approximately 10% of all births and is one of the leading causes of neonatal morbidity and mortality worldwide. Preterm infants are born at a time when kidney development is still ongoing, and consequently can lead to renal impairment (in both the short-term and long-term), as well as severe glomerular abnormalities in some preterm infants. Since the glomerular abnormalities are not present in all preterm kidneys, this suggests that it is not preterm birth per se that leads to the glomerular abnormalities but may relate to factors associated with the etiology of the premature delivery, or factors in neonatal care. In this review, we provide an overview of what is currently known of how prenatal and postnatal factors can potentially impact on the immature kidneys of infants born preterm.

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Maternal cigarette smoking during pregnancy is associated with downregulation ofmiR-16,miR-21, andmiR-146ain the placenta

Cited by 192 publications

References 48 publications

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

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