Maternal chitosan oligosaccharide intervention optimizes the production performance and health status of gilts and their offspring

Ho, T.K.H.; Jahan, Marefa; Haque, Ziaul; Kracht, Susie; Wynn, Peter; Du, Yuguang; Gunn, Allan; Wang, Bing

doi:10.1016/j.aninu.2020.02.001

Cited by 12 publications

(13 citation statements)

References 40 publications

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“…In the present study, maternal COS intervention significantly increased the serum IgM levels in their offspring at the time of marking. This finding is consistent with our previous pig species study [ 18 ] and also, with the study reported by Wan et al [ 24 ], in which maternal COS supplementation improved the serum IgM level in the piglets. It is well recognized that the newborn animals lack sufficient immune protection and therefore, will need passive-immunity from their mother though immunoglobulins present in the colostrum [ 25 ].…”

Section: Discussionsupporting

confidence: 94%

“…The oral administration of COS at doses of 100, 500 and 1000 mg/kg for 7 d significantly reduced oocyst excretion in experimentally induced cryptosporidiosis in lambs [ 17 ]. Recently we reported that maternal COS supplementation during gestation and lactation in gilts increased reproductive efficiency by 4%, milk production by 35% and piglet body weight by 13% [ 18 ]. Serum immunoglobulin M (IgM) and secretory immunoglobulin A (sIgA) in piglets and faecal sIgA in gilts were also significantly increased by material COS supplementation [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently we reported that maternal COS supplementation during gestation and lactation in gilts increased reproductive efficiency by 4%, milk production by 35% and piglet body weight by 13% [ 18 ]. Serum immunoglobulin M (IgM) and secretory immunoglobulin A (sIgA) in piglets and faecal sIgA in gilts were also significantly increased by material COS supplementation [ 18 ]. Dietary COS improves health status in broilers for safe poultry meat production [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Chitosan Oligosaccharide Supplementation Affects Immunity Markers in Ewes and Lambs during Gestation and Lactation

Jahan

Wilson

McGrath

et al. 2022

Animals

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Chitosan oligosaccharide (COS) is derived through deacetylation of chitin from crustacean shells. Previous studies reported the benefits of COS to gut microbiota, immunity and health of host species. In this study, 120 pregnant composite ewes were subdivided into treatment and control groups in duplicate. COS was supplemented via a loose lick to provide an estimated intake of COS @100–600 mg/d/ewe for five weeks pre-lambing until lamb marking. Body weight was recorded pre-treatment for ewes, and at lamb marking and weaning for both ewes and lambs. Serum immunity markers immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA), secretory immunoglobulin A (sIgA), interleukin (IL)-2, IL10 and faecal sIgA were determined for ewes and lambs at lamb marking and weaning by enzyme-linked immunosorbent assay (ELISA). We found that COS can be incorporated in sheep feed without compromising palatability. Maternal COS supplementation did not influence the body weight of ewes or lambs. It did, however, significantly increase the concentrations of serum IL2 in ewes at marking and weaning (p < 0.001). In lambs, COS also significantly increased the IL2 concentration at making (p = 0.018) and weaning (p = 0.029) and serum IgM at marking (p < 0.001). No significant effect was observed in the concentration of any other immune marker or cytokine in either ewes or lambs. In conclusion, maternal COS supplementation significantly modulated some immunity markers in both ewes and lambs. The short duration of maternal COS supplementation and optimal seasonal conditions during the trial may explain the lack of significant body weight in ewes and lambs from the COS supplementation.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chitosan Oligosaccharide Supplementation Affects Immunity Markers in Ewes and Lambs during Gestation and Lactation

Jahan

Wilson

McGrath

et al. 2022

Animals

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“…In addition, COS (100 mg/kg) increased total number of piglets born and weaning weight per litter (20). Importantly, feeding sows with 30 mg/kg or 100 mg/kg COS both increase the serum IgG concentration of piglets, which indicates the enhancement of immune function in neonates (26,33).…”

Section: Soluble Dietary Fibermentioning

confidence: 94%

Maternal Nutrition During Late Gestation and Lactation: Association With Immunity and the Inflammatory Response in the Offspring

Yang

Zhang

et al. 2022

Front. Immunol.

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The immature immune system at birth and environmental stress increase the risk of infection in nursing pigs. Severe infection subsequently induces intestinal and respiratory diseases and even cause death of pigs. The nutritional and physiological conditions of sows directly affect the growth, development and disease resistance of the fetus and newborn. Many studies have shown that providing sows with nutrients such as functional oligosaccharides, oils, antioxidants, and trace elements could regulate immunity and the inflammatory response of piglets. Here, we reviewed the positive effects of certain nutrients on milk quality, immunoglobulin inflammatory response, oxidative stress, and intestinal microflora of sows, and further discuss the effects of these nutrients on immunity and the inflammatory response in the offspring.

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“…Chitosan can also improve milk production and quality, as observed in many farm animals, such as dairy cows (de Paiva et al, 2016) and sows (Ho et al, 2020).…”

Section: Benefits Of Chitosan For Adult Animalsmentioning

confidence: 99%

Multifunctional Role of Chitosan in Farm Animals: A Comprehensive Review

Kamal

Youssef

Khalil

et al. 2023

Annals of Animal Science

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The deacetylation of chitin results in chitosan, a fibrous-like material. It may be produced in large quantities since the raw material (chitin) is plentiful in nature as a component of crustacean (shrimps and crabs) and insect hard outer skeletons, as well as the cell walls of some fungi. Chitosan is a nontoxic, biodegradable, and biocompatible polygluchitosanamine that contains two essential reactive functional groups, including amino and hydroxyl groups. This unique chemical structure confers chitosan with many biological functions and activities such as antimicrobial, anti-inflammatory, antioxidative, antitumor, immunostimulatory and hypocholesterolemic, when used as a feed additive for farm animals. Studies have indicated the beneficial effects of chitosan on animal health and performance, aside from its safer use as an antibiotic alternative. This review aimed to highlight the effects of chitosan on animal health and performance when used as a promising feed additive.

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Maternal chitosan oligosaccharide intervention optimizes the production performance and health status of gilts and their offspring

Cited by 12 publications

References 40 publications

Chitosan Oligosaccharide Supplementation Affects Immunity Markers in Ewes and Lambs during Gestation and Lactation

Chitosan Oligosaccharide Supplementation Affects Immunity Markers in Ewes and Lambs during Gestation and Lactation

Maternal Nutrition During Late Gestation and Lactation: Association With Immunity and the Inflammatory Response in the Offspring

Multifunctional Role of Chitosan in Farm Animals: A Comprehensive Review

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