Maternal care exerts disease‐modifying effects on genetic absence epilepsy and comorbid depression

Sarkisova, K. Yu.; Gabova, Alexandra V.

doi:10.1111/gbb.12477

Cited by 29 publications

(37 citation statements)

References 56 publications

(87 reference statements)

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“…The particularity of this research is the special social status of these teenagers. Institutionalized minors from families with a poor medical, cultural and socio-economic situation often have multiple associated diseases [7,20]. The determination of risks in this particular social category has been a strong point of this research.…”

Section: Resultsmentioning

confidence: 99%

The Influence of Smoking on Nicotine Exposure Biomarkers and Inflammatory Profile Among Foster Care Teenagers, Romania

Budin¹,

Marginean²,

Bordea³

et al. 2019

Rev. Chim.

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Foster care young people have an increased overall risk for the development of chronic health conditions.Smoking is a major risk factor for many conditions with inflammatory component. We performed a cross-sectional pilot study to assess the correlation between tobacco consumption status and inflammatory profile among adolescents living with foster parents in the central region of Romania. A number of 35 teenagers aged 10-18 were enrolled. Blood samples were collected by venipuncture for complete blood count (CBC), fibrinogen, Interleukin-6 (IL 6), C reactive protein (CRP). Exhaled CO was measured and urine samples were collected in the same session for cotinine assessment. Of the 123 teenagers initially enrolled, 35 completed the entire study protocol. Urinary cotinine accurately reflected smoker status. Smoking did not affect hemoglobin levels or other hematological parameters in foster care teenagers. The value of C-reactive protein was higher in smokers. Plasma fibrinogen correlated with the daily number of cigarettes. Interleukin-6 did not correlate with the smoker status or the daily number of cigarettes consumed. Our study highlights the existence of an inflammatory response to smoking in foster care adolescents, a social category otherwise predisposed to various addictive behaviors.

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Section: Resultsmentioning

confidence: 99%

The Influence of Smoking on Nicotine Exposure Biomarkers and Inflammatory Profile Among Foster Care Teenagers, Romania

Budin¹,

Marginean²,

Bordea³

et al. 2019

Rev. Chim.

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“…However, number and/or duration of SWDs can be different between rats. Therefore, inheritance is improbable to be linked to a single gene locus; this is further sustained by the crucial role played by epigenetic factors [20][21][22]. To date, genes that control SWDs, in these rats, have only been detected on chromosomes 5 and 9 [23], whereas none specific gene mutation was detected for the SRS onset in this strain [17].…”

Section: The Genetically-programmed Epileptogenic Process In Wag/rij mentioning

confidence: 90%

WAG/Rij rat model: a resource for the pharmacology of epileptogenesis and related neurological/psychiatric comorbidities

Leo

Nesci

et al. 2019

Neurosci Res Notes

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The discovery of potential antiseizure drugs (ASDs) requires the use of experimental models that can also provide a unique chance for identifying new effective molecules able to prevent and/or cure epilepsy. Most of the preclinical knowledge on epileptogenesis derives from studies performed on post-insult models that are characterized by a recognizable first insult, a silent period lasting until the onset of the first seizure and a chronic period characterized by spontaneous recurrent seizures (SRSs). At odds, genetic models, in which the first insult remains to be identified, have been poorly investigated. Among the genetic models, the WAG/Rij rat was validated as a suitable experimental model of absence epileptogenesis with neuropsychiatric symptomatology, in which, according to our previous hypothesis on SRSs onset, genes could be considered the first ‘insult’ underlying all plastic modifications supporting the occurrences of absence seizures in this strain. In fact, in several genetic models, the initial insult could be described as the mutation leading to epilepsy that, to date, remains to be defined in this strain. The silent period ends at the occurrence of the first SRS, which is approximately at 2-3 months of age in these rats and after that time the chronic phase initiates, in which, absence seizures increase over time underlying likely further epileptogenic processes. In this review, we describe both the features of this experimental model and the effects of several pharmacological treatments against epileptogenesis and its related comorbidities including depressive-like symptoms and cognitive decline.

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“…Mainly early environmental factors were described affecting incidence and duration in WAG/Rij rats, e.g. maternal (Peeters et al, 1992b;Sitnikova et al, 2016;Sarkisova and Gabova, 2018) and housing effects (Schridde and van Luijtelaar, 2004). Moreover, large differences in incidence were described in the GAERS model between labs in different continents as well (Powell et al, 2014).…”

Section: The Design Of the Study: Which Rats To Usementioning

confidence: 99%

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

Luijtelaar

Oijen

2020

Front. Pharmacol.

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The genetic rat models such as rats of the WAG/Rij strain and GAERS were developed as models for generalized genetic epilepsy and in particular for childhood absence epilepsy. These animal models were described in the eighties of the previous century and both models have, among others, face, construct and predictive validity. Both models were and are currently used as models to predict the action of antiepileptic medication and other experimental treatments, to elucidate neurobiological mechanisms of spike-wave discharges and epileptogenesis. Although the electroencephalagram (EEG)/ electrocorticogram (ECoG) is imperative for establishing absence seizures and to quantify the for absence epilepsy typical spike-wave discharges, monitoring the animals behavior is equally necessary. Here an overview is given regarding the design of drug evaluation studies, which animals to use, classical and new EEG variables, the monitoring and quantification of the behavior of the rats, some pitfalls regarding the interpretation of the data, and some developments in EEG technology.

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Maternal care exerts disease‐modifying effects on genetic absence epilepsy and comorbid depression

Cited by 29 publications

References 56 publications

The Influence of Smoking on Nicotine Exposure Biomarkers and Inflammatory Profile Among Foster Care Teenagers, Romania

The Influence of Smoking on Nicotine Exposure Biomarkers and Inflammatory Profile Among Foster Care Teenagers, Romania

WAG/Rij rat model: a resource for the pharmacology of epileptogenesis and related neurological/psychiatric comorbidities

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

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