Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea

Williams, Frank B.; Kader, Md. Abdul; Dickson, Dorothy M.; Colgate, E. Ross; Alam, Masud; Haque, Rashidul; Petri, William A.; Kirkpatrick, Beth D.; Lee, Benjamin

doi:10.1093/ofid/ofad299

Cited by 1 publication

(1 citation statement)

References 12 publications

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“…Additional inclusion of serial RV-specific antibody measurements, as has been performed in other RV birth cohort studies [ 38 , 39 ] would have helped mitigate this, but unfortunately serial blood samples were not available for this purpose. We have previously shown that maternal secretor status affects Rotarix seroconversion but not natural infections in unvaccinated infants, likely because maternal effects wane after the early infancy period and may be confounded by associations with maternal antibody levels [ 40 , 41 ]. For these reasons, maternal status was not further evaluated here.…”

Section: Discussionmentioning

confidence: 99%

Infant Non-Secretor Histoblood Group Antigen Phenotype Reduces Susceptibility to Both Symptomatic and Asymptomatic Rotavirus Infection

Lee,

Kader,

Alam

et al. 2024

Pathogens

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The infant non-secretor histoblood group antigen phenotype is associated with reduced risk of symptomatic rotavirus diarrhea, one of the leading global causes of severe pediatric diarrheal disease and mortality. However, little is known regarding the role of secretor status in asymptomatic rotavirus infections. Therefore, we performed a nested case–control study within a birth cohort study previously conducted in Dhaka, Bangladesh, to determine the association between infant secretor phenotype and the odds of asymptomatic rotavirus infection, in addition to the risk of rotavirus diarrhea, in unvaccinated infants. In the parent cohort, infants were enrolled in the first week of life and followed through the first two years of life with multiple clinic visits and active surveillance for diarrheal illness. Secretor phenotyping was performed on saliva. Eleven surveillance stools collected over the first year of life were tested for rotavirus by real-time RT-PCR, followed by conventional PCR and amplicon sequencing to identify the infecting P-type of positive specimens. Similar to findings for symptomatic diarrhea, infant non-secretors experienced significantly fewer primary episodes of asymptomatic rotavirus infection through the first year of life in a likely rotavirus P-genotype-dependent manner. These data suggest that non-secretors experienced reduced risk from rotavirus due to decreased susceptibility to infection rather than reduced infection severity.

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