Maternal body mass index is not associated with increased rates of maternal embryonic aneuploidy

Hughes, Lydia; McQueen, Dana B.; Jungheim, Emily S.; Merrion, Katrina; Boots, Christina E.

doi:10.1016/j.fertnstert.2021.12.031

Cited by 14 publications

(4 citation statements)

References 40 publications

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“…The number or percentage of aneuploid, mosaic, or euploid fetuses was not really related to BMI [9]. 3.…”

Section: Bellver Et Al Stated That Obese and Normal-weightmentioning

confidence: 88%

Update on obesity and assisted reproductive technology

Elnashar

2023

Middle East Fertil Soc J

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Background The effect of obesity on IVF consequences is still debatable. Main body Obesity is linked to a greater likelihood of maternal and fetal complications all through gestation, including miscarriage, premature births, fetal demise, and adverse pregnancy outcomes. There was no increase in chromosomal abnormality percentages with increasing body mass index (BMI), implying that poor oocyte “performance” in obese patients could be caused by variables other than chromosomal expertise. Ribonucleic acid (RNA)-sequence research showed molecular changes in the oocytes of obese patients. Each 5-unit rise in female BMI is attributed with both a 5% and 7% reduction in hazard for CPR and LBR, in both, and a 9% rise in the comparative chance of miscarriage. There is no clinical or moral mandate for establishing a societal BMI limit for rejecting a client or couple direct exposure to infertility treatment. Assessment with an interdisciplinary approach prior to an IVF treatment should be done to assess the safety of oocyte retrieval under anesthesia, taking into account variables including body mass index and comorbid conditions. On LBR, there is no convincing evidence of the significance of lifestyle modification for losing weight. There is contradictory information on the impacts of weight loss surgery on pregnancy outcomes. IVF success rate was unaffected by weight loss surgery. Conclusion Obesity has been linked to anovulation, decreased ovarian response to ovulatory prescription medications, changed oocyte and endometrial activity, an elevated risk of fertility problems, and reduced rates of live birth following IVF.

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“…The number or percentage of aneuploid, mosaic, or euploid fetuses was not really related to BMI [9]. 3.…”

Section: Bellver Et Al Stated That Obese and Normal-weightmentioning

confidence: 88%

Update on obesity and assisted reproductive technology

Elnashar

2023

Middle East Fertil Soc J

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“…Maternal BMI was not associated with higher rates of preimplantation embryonic aneuploidy. 18 19 In addition, paternal obesity was also not found to be associated with higher rates of preimplantation embryonic aneuploidy. 20…”

Section: Pathophysiology Between Obesity and Miscarriagementioning

confidence: 88%

“…Maternal BMI was not associated with higher rates of preimplantation embryonic aneuploidy. 18,19 In addition, paternal obesity was also not found to be associated with higher rates of preimplantation embryonic aneuploidy. 20 In support of these findings, several other clinical, human studies have evaluated products of conception after an early pregnancy loss and come to the same conclusion.…”

Section: Embryomentioning

confidence: 93%

Obesity and Miscarriage

McLean,

Boots

2023

Semin Reprod Med

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Obesity affects nearly 40% of reproductive-aged women and has serious implications for women's overall and reproductive health. Women with an elevated body mass index (BMI) have higher rates of anovulation and irregular menses, lower success with fertility treatment, and significantly higher rates of pregnancy complications, such as hypertension/preeclampsia, gestational diabetes, and preterm delivery. Many studies have also shown an association between obesity and early pregnancy loss. However, the causal association between BMI and miscarriage has not been elucidated, likely due to the multifactorial effects that BMI may have on early pregnancy development. In addition, BMI as an isolated variable fails to capture other relevant confounding health risk factors, such as nutrition, physical activity, and insulin resistance. In this review, we will summarize the current literature demonstrating the association between BMI and miscarriage, highlight the research that attempts to explain the association, and finally provide data on therapeutic interventions to improve reproductive outcomes in women suffering from obesity and early pregnancy loss.

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“…To emphasize the controversy, in a previous report on ART, BMI was associated with embryogenesis 2 ; however, no effect was reported 3 . One previous study reported no difference in the ratio of chromosomal aneuploidy between women with and without obesity in preimplantation genetic testing for aneuploidy 4 , 5 . In addition, obesity in women has been associated with decreased pregnancy or live birth rates 6 – 11 , although some reports suggest no such association 2 , 12 – 14 .…”

mentioning

confidence: 92%

Maternal body mass index is not associated with assisted reproductive technology outcomes

Kidera,

Ishikawa,

Kawamura

et al. 2023

Sci Rep

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The effects of body mass index (BMI) on assisted reproductive technology (ART) outcomes such as ovarian dysfunction, poor ovum quality, and endometrial dysfunction have been studied; however, many aspects remain controversial. Therefore, we retrospectively investigated the relationship between BMI and ART outcomes. For 14,605 oocyte retrieval cycles at our hospital between January 2016 and December 2020, BMI was divided into five groups (< 18.5, 18.5–20.0, 20.0–22.5, 22.5–25.0, ≥ 25 kg/m2) and measured before oocyte retrieval. The normal fertilization and high-grade blastocyst rates were compared. In addition, in the 7,122 frozen-thawed embryo transfers (FET) with highest-grade embryos, the clinical pregnancy, miscarriage, and live birth rates were investigated in the five BMI groups. Multiple regression analysis on normal fertilization and high-grade blastocyst rates revealed no statistically significant differences. Furthermore, after propensity score matching on FET, there was no significant difference in clinical pregnancy, miscarriage, and live birth rates in the BMI groups. BMI is a risk factor for complications during pregnancy; however, it does not affect ART outcomes. Therefore, we believe weight guidance should be provided to women with obesity at the start of infertility treatment, but treatment should not be delayed.

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Maternal body mass index is not associated with increased rates of maternal embryonic aneuploidy

Cited by 14 publications

References 40 publications

Update on obesity and assisted reproductive technology

Update on obesity and assisted reproductive technology

Obesity and Miscarriage

Maternal body mass index is not associated with assisted reproductive technology outcomes

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