Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis

Liu, Lei; Ma, Yanan; Wang, Ningning; Lin, Wenjing; Yang, Liu; Wen, Deliang

doi:10.1186/s12884-019-2249-z

Cited by 101 publications

(101 citation statements)

References 42 publications

(69 reference statements)

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“…Unlike the current study, previous research found preterm birth and LBW to be associated with other factors as well-for example, LBW with maternal age [12,45] and maternal BMI [45,46] and preterm birth with maternal age [4,14] and maternal BMI [14,46,47].…”

Section: Discussioncontrasting

confidence: 98%

Factors Associated with Preterm Birth and Low Birth Weight in Abu Dhabi, the United Arab Emirates

Taha

Hassan²,

Wikkeling-Scott

et al. 2020

IJERPH

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Both preterm birth and low birth weight (LBW) represent major public health problems worldwide due to their association with the catastrophic effects of morbidity and mortality. Few data exist about such adverse pregnancy outcomes. The current study aimed to investigate the prevalence of and factors associated with preterm birth and LBW among mothers of children under two years in Abu Dhabi, United Arab Emirates. Data were collected in clinical and non-clinical settings across various geographical areas in Abu Dhabi. The data were analyzed using both descriptive and inferential statistics. A total of 1610 mother–child pairs were included in the current study. Preterm birth rate was 102 (6.3%) with a 95% confidence interval [CI] (6.1%, 6.5%) and the LBW rate was 151 (9.4%) with a 95% CI (9.3%, 9.5%). The mean (SD) of gestational age (GA) and birth weight at delivery was 39.1 (1.9) weeks and 3080.3 (518.6) grams, respectively. Factors that were positively associated with preterm birth were Arab mothers, maternal education level below secondary, caesarean section, and LBW. LBW was associated with female children, caesarean section (CS), first child order, and preterm birth. The current study highlighted the need for further interventional research to tackle these public health issues such as reducing the high CS rate and improving maternal education.

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Section: Discussioncontrasting

confidence: 98%

Factors Associated with Preterm Birth and Low Birth Weight in Abu Dhabi, the United Arab Emirates

Taha

Hassan²,

Wikkeling-Scott

et al. 2020

IJERPH

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“…Over the past few decades, overweight and obesity have become a growing health problem in the Western world [1], so much so that WHO now considers it one of the most relevant health problems [2]. The distribution of this problem is not homogeneous among the population, being women's rates higher than men's [3], and this makes obesity a problem that greatly affects women of reproductive age.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Many experimental and epidemiological studies show that nutritional changes in the prenatal and postnatal stages of life can have a significant impact on the child's health and development [2,3,[7][8][9]. Maternal overweight, obesity, and morbid obesity are already known to be associated with adverse obstetric and neonatal outcomes [3,10]. In particular, maternal obesity is associated with gestational diabetes mellitus (GDM) [11,12], preeclampsia [12], congenital malformations and macrosomia [3], preterm birth [3], low Apgar scores [4], admittance to neonatal intensive care unit [13], low-weight newborns [3,14], and with an increase in obstetric interventions such as pregnancy caesarean section [12,15] and labor induction [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Maternal Body Mass Index and Obstetric and Perinatal Complications

Ballesta‐Castillejos

Gómez‐Salgado

Rodríguez‐Almagro

et al. 2020

JCM

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Over the past few decades, overweight and obesity have become a growing health problem of particular concern for women of reproductive age as obesity in pregnancy has been associated with increased risk of obstetric and neonatal complications. The objective of this study is to describe the incidence of obstetric and perinatal complications in relation to maternal body mass index (BMI) at the time prior to delivery within the Spanish Health System. For this purpose, a cross-sectional observational study was conducted aimed at women who have been mothers between 2013 and 2018 in Spain. Data were collected through an online survey of 42 items that was distributed through lactation associations and postpartum support groups. A total of 5871 women answered the survey, with a mean age of 33.9 years (SD = 4.26 years). In the data analysis, crude odds ratios (OR) and adjusted odds ratios (AOR) were calculated through a multivariate analysis. A linear relationship was observed between the highest BMI figures and the highest risk of cephalopelvic disproportion (AOR of 1.79 for obesity type III (95% CI: 1.06–3.02)), preeclampsia (AOR of 6.86 for obesity type III (3.01–15.40)), labor induction (AOR of 1.78 for obesity type III (95% CI: 1.16–2.74)), emergency C-section (AOR of 2.92 for obesity type III (95% CI: 1.68–5.08)), morbidity composite in childbirth (AOR of 3.64 for obesity type III (95% CI: 2.13–6.24)), and macrosomia (AOR of 6.06 for obesity type III (95% CI: 3.17–11.60)), as compared with women with normoweight. Women with a higher BMI are more likely to develop complications during childbirth and macrosomia.

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“…Globally, GDM affects 3-25% pregnancies, and the continued increase in the incidence of this disease is consistent with an increasing prevalence of obesity [7]. Both maternal obesity and GDM are independent risk factors for obstetric and neonatal complications, such as caesarean section, macrosomia, preeclampsia, or other metabolic disorders at multiple life stages in the offspring [8,9]. It seems, nonetheless, that obese women with GDM appear to have a higher risk of adverse outcomes than women who suffered from obesity alone or GDM alone [10,11].…”

Section: Introductionmentioning

confidence: 99%

Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women

Liu

Yang

et al. 2020

Disease Markers

Self Cite

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Background. Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepregnancy overweight/obesity and GDM and at clarifying the relationship between the WISP1 level and clinical cardiometabolic parameters. Methods. A total of 313 participants were screened from a multicenter prospective prebirth cohort: Born in Shenyang Cohort Study (BISCS). Subjects were examined with a 2×2 factorial design for body mass index BMI≥24 and GDM. Between 24 and 28 weeks of pregnancy, follow-up individuals underwent an OGTT and blood sampling for cardiometabolic characterization. Results. We observed that the WISP1 levels were elevated in prepregnancy overweight/obesity patients with GDM, compared with nonoverweight subjects with normal blood glucose (3.45±0.89 vs. 2.91±0.75 ng/mL). Multilogistic regression analyses after adjustments for potential confounding factors revealed that WISP1 was a strong and independent risk factor for prepregnancy overweight/obesity with GDM (all ORs>1). In addition, the results of the ROC analysis indicated that WISP1 exhibited the capability to identify individuals with prepregnancy overweight/obesity and GDM (all AUC>0.5). Finally, univariate and multivariate linear regression showed that WISP1 level was positively and independently correlated with fasting blood glucose, systolic blood pressure, and aspartate aminotransferase and was negatively correlated with HDL-C and complement C1q. Conclusions. WISP1 may be critical for the prediction, diagnosis, and therapeutic strategies against obesity and GDM in pregnant women.

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Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis

Cited by 101 publications

References 42 publications

Factors Associated with Preterm Birth and Low Birth Weight in Abu Dhabi, the United Arab Emirates

Factors Associated with Preterm Birth and Low Birth Weight in Abu Dhabi, the United Arab Emirates

Relationship between Maternal Body Mass Index and Obstetric and Perinatal Complications

Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women

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