2021
DOI: 10.1096/fj.202101131r
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Maternal background alters the penetrance of growth phenotypes and sex‐specific placental adaptation of offspring sired by alcohol‐exposed males

Abstract: Epigenetic mechanisms of paternal inheritance are an emerging area of interest in our efforts to understand fetal alcohol spectrum disorders. In rodent models examining maternal alcohol exposures, different maternal genetic backgrounds protect or sensitize offspring to alcohol‐induced teratogenesis. However, whether maternal background can mitigate sperm‐inherited alterations in developmental programming and modify the penetrance of growth defects induced by preconception paternal alcohol exposures remains una… Show more

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Cited by 17 publications
(25 citation statements)
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References 77 publications
(137 reference statements)
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“…We suspect that similar to previous studies, reduced CTCF destabilizes Enhancer-Promoter interactions required to maintain appropriate gene expression patterns 29 . Further, reductions in these critical transport proteins may contribute to the growth deficits we observe in alcohol-exposed offspring 31 33 , 36 .…”
Section: Discussionmentioning
confidence: 92%
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“…We suspect that similar to previous studies, reduced CTCF destabilizes Enhancer-Promoter interactions required to maintain appropriate gene expression patterns 29 . Further, reductions in these critical transport proteins may contribute to the growth deficits we observe in alcohol-exposed offspring 31 33 , 36 .…”
Section: Discussionmentioning
confidence: 92%
“…To this end, we used our published Drinking in the Dark model to expose adult (postnatal day 90) C57BL/6 J males to either water or 10% ethanol (EtOH) for ten weeks. After verifying the impact of the preconception EtOH treatment on placental growth 36 , we euthanized the sires and generated sperm ChIP-seq libraries from control and EtOH-exposed males (n = 3 and 4), with an average of 50 million unique reads per sample.…”
Section: Resultsmentioning
confidence: 99%
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