Maternal asthma, race and low birth weight deliveries

Aly, Hany; Nada, Ayman; Ahmad, Tahmina; Mohamed, Mohamed; Massaro, An N.; Bathgate, Susanne L.; Macri, Charles J.; Larsen, John W.

doi:10.1016/j.earlhumdev.2011.03.007

Cited by 7 publications

(8 citation statements)

References 30 publications

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“…The adverse impact of asthma in pregnancy on most outcomes is striking. Although increased risks of haemorrhage during pregnancy, premature contractions, placental abruption and SGA have been observed in some previous studies [5], [6], [9], [12]–[14], [28]–[30], the novelty with our results is the consistency in risk increases for women with asthma before and during pregnancy across all pregnancy and labour characteristics, as well as most perinatal outcomes. This has not been previously shown and has important public health implications.…”

Section: Discussionsupporting

confidence: 61%

Asthma during Pregnancy in a Population-Based Study - Pregnancy Complications and Adverse Perinatal Outcomes

et al. 2014

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BackgroundAsthma is one of the most common chronic diseases, and prevalence, severity and medication may have an effect on pregnancy. We examined maternal asthma, asthma severity and control in relation to pregnancy complications, labour characteristics and perinatal outcomes.MethodsWe retrieved data on all singleton births from July 1, 2006 to December 31, 2009, and prescribed drugs and physician-diagnosed asthma on the same women from multiple Swedish registers. The associations were estimated with logistic regression.ResultsIn total, 266 045 women gave birth to 284 214 singletons during the study period. Maternal asthma was noted in 26 586 (9.4%) pregnancies. There was an association between maternal asthma and increased risks of pregnancy complications including preeclampsia or eclampsia (adjusted OR 1.15; 95% CI 1.06–1.24) and premature contractions (adj OR 1.52; 95% CI 1.29–1.80). There was also a significant association between maternal asthma and emergency caesarean section (adj OR 1.29; 95% CI 1.23–1.34), low birth weight, and small for gestational age (adj OR 1.23; 95% CI 1.13–1.33). The risk of adverse outcomes such as low birth weight increased with increasing asthma severity. For women with uncontrolled compared to those with controlled asthma the results for adverse outcomes were inconsistent displaying both increased and decreased OR for some outcomes.ConclusionMaternal asthma is associated with a number of serious pregnancy complications and adverse perinatal outcomes. Some complications are even more likely with increased asthma severity. With greater awareness and proper management, outcomes would most likely improve.

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Section: Discussionsupporting

confidence: 61%

Asthma during Pregnancy in a Population-Based Study - Pregnancy Complications and Adverse Perinatal Outcomes

et al. 2014

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“…We found that a maternal history of allergic disease may be negatively associated with BW. Previous studies have found conflicting results concerning the impact of maternal allergic diseases on BW (1, 23-27). Asthma during pregnancy is associated with physiological changes in the expectant mother (28).…”

Section: Discussionmentioning

confidence: 95%

“…Birth weight (BW) has long been recognized as a good surrogate marker for fetal well-being (1) as well as a key determinant of neonatal mortality, morbidity, subsequent growth and development, and an early onset of adulthood disease (2). Low birth weight (LBW) is associated with inadequate fetal nutritional status and growth restriction, and increases the risk of serious neonatal morbidity or death (1), whereas macrosomia is associated with an increased risk of obstetric complications, such as birth injury and cesarean section (3).…”

Section: Introductionmentioning

confidence: 99%

“…Low birth weight (LBW) is associated with inadequate fetal nutritional status and growth restriction, and increases the risk of serious neonatal morbidity or death (1), whereas macrosomia is associated with an increased risk of obstetric complications, such as birth injury and cesarean section (3). BW is also a predictor of allergic diseases, obesity, diabetes mellitus, and cardiovascular disease in later life (4-7).…”

Section: Introductionmentioning

confidence: 99%

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Association between Maternal Characteristics and Neonatal Birth Weight in a Korean Population Living in the Seoul Metropolitan Area, Korea: A Birth Cohort Study (COCOA)

et al. 2013

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Previous studies suggest that maternal characteristics may be associated with neonatal outcomes. However, the influence of maternal characteristics on birth weight (BW) has not been adequately determined in Korean populations. We investigated associations between maternal characteristics and BW in a sample of 813 Korean women living in the Seoul metropolitan area, Korea recruited using data from the prospective hospital-based COhort for Childhood Origin of Asthma and allergic diseases (COCOA) between 2007 and 2011. The mean maternal age at delivery was 32.3 ± 3.5 yr and prepregnancy maternal body mass index (BMI) was 20.7 ± 2.5 kg/m2. The mean BW of infant was 3,196 ± 406 g. The overall prevalence of a maternal history of allergic disease was 32.9% and the overall prevalence of allergic symptoms was 65.1%. In multivariate regression models, prepregnancy maternal BMI and gestational age at delivery were positively and a maternal history of allergic disease and nulliparity were negatively associated with BW (all P < 0.05). Presence of allergic symptoms in the mother was not associated with BW. In conclusion, prepregnancy maternal BMI, gestational age at delivery, a maternal history of allergic disease, and nulliparity may be associated with BW, respectively.

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“…Adverse perinatal outcomes, such as a preterm birth, a low-birth-weight (LBW) infant and a small-for-gestational-age (SGA) infant, have been reported to be higher in pregnant women with asthma when compared to women without asthma in some studies [2][3][4][5][6][7][8][9][10], but not in other studies [11][12][13][14][15][16][17][18]. In a meta-analysis conducted by Murphy et al, asthmatic women with and without asthma exacerbations during pregnancy were compared to non-asthmatic women for the risk of LBW infant and preterm delivery [19].…”

Section: Introductionmentioning

confidence: 99%

Impact of maternal asthma on perinatal outcomes: a two-stage sampling cohort study

et al. 2012

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There are conflicting results concerning the impact of maternal asthma during pregnancy on perinatal outcomes. The present study investigated the associations between maternal asthma during pregnancy and the risk of a small-for-gestational-age (SGA) infant, a low-birth-weight (LBW) infant, and preterm birth. A population-based cohort of 40,788 pregnancies from asthmatic and non-asthmatic women was reconstructed through the linking of three Quebec (Canada) administrative databases between 1990 and 2002. A two-stage sampling cohort design was used to collect additional information by way of a mailed questionnaire. The generalized estimation equation models were used to obtain adjusted odds ratios of SGA, LBW and preterm birth comparing asthmatic and non-asthmatic women. The cohort included 13,007 pregnancies from asthmatic and 27,781 pregnancies from non-asthmatic women. Final estimates showed that the odds of SGA (odds ratio: 1.27, 95% confidence interval: 1.14, 1.41), LBW (1.41: 1.22, 1.63) and preterm delivery (1.64: 1.46, 1.83) were significantly higher among asthmatic than non-asthmatic women. Mothers with asthma during pregnancy are more likely to have SGA, LBW, or preterm birth infants than non-asthmatic women. These results can be more easily generalized to women with lower socio-economic status since the cohort under represents women with high socio-economic status.

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Maternal asthma, race and low birth weight deliveries

Cited by 7 publications

References 30 publications

Asthma during Pregnancy in a Population-Based Study - Pregnancy Complications and Adverse Perinatal Outcomes

Asthma during Pregnancy in a Population-Based Study - Pregnancy Complications and Adverse Perinatal Outcomes

Association between Maternal Characteristics and Neonatal Birth Weight in a Korean Population Living in the Seoul Metropolitan Area, Korea: A Birth Cohort Study (COCOA)

Impact of maternal asthma on perinatal outcomes: a two-stage sampling cohort study

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