Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts

Belinelo, Patricia de Gouveia; Collison, Adam; Murphy, Vanessa E.; Robinson, Paul D.; Jesson, Kathryn; Hardaker, Kate; Andrade, Ediane De Queiroz; Oldmeadow, Christopher; Gomes, Gabriela Martins Costa; Sly, Peter D.; Usemann, Jakob; Appenzeller, Rhea; Gorlanova, Olga; Fuchs, Oliver; Latzin, Philipp; Gibson, Péter G.; Frey, Urs; Mattes, Joërg

doi:10.1136/thoraxjnl-2020-215526

Cited by 16 publications

(24 citation statements)

References 34 publications

(30 reference statements)

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“…However, there is often heterogeneity in asthma onset particularly between gender and age. Males are more likely to be diagnosed pre-puberty and to have a heritable component to their disease ( 1 , 12 , 13 ). Females, in contrast, are often diagnosed with asthma later in life.…”

Section: What Is Paediatric Asthma and Why Is Wheezing Important?mentioning

confidence: 99%

Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis

et al. 2021

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The epithelium is integral to the protection of many different biological systems and for the maintenance of biochemical homeostasis. Emerging evidence suggests that particular children have epithelial vulnerabilities leading to dysregulated barrier function and integrity, that resultantly contributes to disease pathogenesis. These epithelial vulnerabilities likely develop in utero or in early life due to various genetic, epigenetic and environmental factors. Although various epithelia are uniquely structured with specific function, prevalent allergic-type epithelial diseases in children potentially have common or parallel disease processes. These include inflammation and immune response dysregulation stemming from atypical epithelial barrier function and integrity. Two diseases where aetiology and pathogenesis are potentially linked to epithelial vulnerabilities include Paediatric Asthma and Eosinophilic Oesophagitis (EoE). For example, rhinovirus C (RV-C) is a known risk factor for paediatric asthma development and is known to disrupt respiratory epithelial barrier function causing acute inflammation. In addition, EoE, a prevalent atopic condition of the oesophageal epithelium, is characterised by similar innate immune and epithelial responses to viral injury. This review examines the current literature and identifies the gaps in the field defining viral-induced effects on a vulnerable respiratory epithelium and resulting chronic inflammation, drawing from knowledge generated in acute wheezing illness, paediatric asthma and EoE. Besides highlighting the importance of epithelial structure and barrier function in allergic disease pathogenesis regardless of specific epithelial sub-types, this review focuses on the importance of examining other parallel allergic-type disease processes that may uncover commonalities driving disease pathogenesis. This in turn may be beneficial in the development of common therapeutics for current clinical management and disease prevention in the future.

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Section: What Is Paediatric Asthma and Why Is Wheezing Important?mentioning

confidence: 99%

Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis

et al. 2021

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“…The main parameter taken from TBFVL was the time to peak tidal expiratory flow divided by the total time of tidal expiratory flow (tPTEF/tE%). According to the normative data created by the Bern infant lung development cohort, chosen because of similarities in methodology and characteristics of the sample, babies born from non‐asthmatic mothers had the mean tPTEF/tE% of 34.9 17,76 …”

Section: Methodsmentioning

confidence: 99%

“…According to the normative data created by the Bern infant lung development cohort, chosen because of similarities in methodology and characteristics of the sample, babies born from non‐asthmatic mothers had the mean tPTEF/tE% of 34.9. 17 , 76 …”

Section: Methodsmentioning

confidence: 99%

“…Lung function is an objective parameter to assess respiratory outcomes very early in life, at a time when respiratory symptoms are yet to develop. Lung function parameters are sensitive to conditions and exposures adversely affecting the foetus, such as premature birth, in utero tobacco smoke exposure and maternal asthma in pregnancy 15‐17 . Environmental exposure to air pollution in childhood can increase the risk of developing asthma even in individuals with high lung function in infancy 18 .…”

Section: Introductionmentioning

confidence: 99%

“…Lung function parameters are sensitive to conditions and exposures adversely affecting the foetus, such as premature birth, in utero tobacco smoke exposure and maternal asthma in pregnancy. 15 , 16 , 17 Environmental exposure to air pollution in childhood can increase the risk of developing asthma even in individuals with high lung function in infancy. 18 While several studies have shown that infants with poor lung function at birth are at increased risk of the subsequent development of asthma, this has not been universally reported 19 , 20 , 21 , 22 , 23 and further work is required to understand the nuanced relationship between lung function and asthma through childhood.…”

Section: Introductionmentioning

confidence: 99%

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Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age

et al. 2021

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Objective. Offspring born to mothers with asthma in pregnancy are known to have lower lung function which tracks with age. Human group 2 innate lymphoid cells (ILC2) accumulate in foetal lungs, at 10-fold higher levels compared to adult lungs. However, there are no data on foetal ILC2 numbers and the association with respiratory health outcomes such as lung function in early life. We aimed to investigate cord blood immune cell populations from babies born to mothers with asthma in pregnancy. Methods. Cord blood from babies born to asthmatic mothers was collected, and cells were stained in whole cord blood. Analyses were done using traditional gating approaches and computational methodologies (t-distributed stochastic neighbour embedding and PhenoGraph algorithms). At 6 weeks of age, the time to peak tidal expiratory flow as a percentage of total expiratory flow time (tPTEF/tE%) was determined as well as Lung Clearance Index (LCI), during quiet natural sleep. Results. Of 110 eligible infants (March 2017 to November 2019), 91 were successfully immunophenotyped (82.7%). Lung function was attempted in 61 infants (67.0%), and 43 of those infants (70.5% of attempted) had technically acceptable tPTEF/tE% measurements. Thirty-four infants (55.7% of attempted) had acceptable LCI measurements. Foetal ILC2 numbers with increased expression of chemoattractant receptorhomologous molecule (CRTh2), characterised by two distinct analysis methodologies, were associated with poorer infant lung function at 6 weeks of age." Conclusion. Foetal immune responses may be a surrogate variable for or directly influence lung function outcomes in early life.

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Fetal thoracic circumference in mid‐pregnancy and infant lung function

Guðmundsdóttir

Hilde

Bains

et al. 2022

Pediatric Pulmonology

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Background and Aim: Impaired lung function in early infancy is associated with later wheeze and asthma, while fetal thoracic circumference (TC) predicts severity of neonatal lung hypoplasia. Exploring fetal origins of lung function in infancy, we aimed to determine if fetal TC in mid-pregnancy was associated with infant lung function.Methods: From the prospective Scandinavian general population-based PreventA-DALL mother-child birth cohort, all 851 3-month-old infants with tidal flow-volume measurements in the awake state and ultrasound fetal size measures at 18 (min-max 16-22) weeks gestational age were included. Associations between fetal TC and time to peak tidal expiratory flow to expiratory time (t PTEF /t E ) were analyzed in linear regression models. To account for gestational age variation, we adjusted TC for simultaneously measured general fetal size, by head circumference (TC/HC), abdominal circumference (TC/AC), and femur length (TC/FL). Multivariable models

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Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts

Cited by 16 publications

References 34 publications

Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis

Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis

Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age

Fetal thoracic circumference in mid‐pregnancy and infant lung function

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