Maternal arterial stiffness in normotensive pregnant women who subsequently deliver babies that are small for gestational age

Tomimatsu, Takuji; Fujime, Mika; Kanayama, Tomoko; Mimura, Kazuya; Koyama, Shinsuke; Kanagawa, Takeshi; Kimura, Tadashi

doi:10.1016/j.ejogrb.2013.01.016

Cited by 17 publications

(14 citation statements)

References 36 publications

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“…Blood flow to many organs, especially the kidneys and uterus, increases markedly during normal pregnancy and demands a rapid increase in cardiac output, which is achieved by an increase in heart rate and stroke volume. Maladaptation of the cardiovascular system to pregnancy is associated with hypertensive disorders during pregnancy, such as pre‐eclampsia, and impaired fetal growth. A reproductive history, including normal gestation, is a protective factor against future cardiovascular disease and, conversely, hypertensive pregnancy‐related disorders are associated with an increased future cardiovascular risk.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal study of vascular structure and function during normal pregnancy

Iacobaeus

Andolf

Thorsell

et al. 2017

Ultrasound in Obstet & Gyne

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Section: Introductionmentioning

confidence: 99%

Longitudinal study of vascular structure and function during normal pregnancy

Iacobaeus

Andolf

Thorsell

et al. 2017

Ultrasound in Obstet & Gyne

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“…Increased systemic arterial stiffness has been reported among women with hypertensive disorders during pregnancy [7][8][9] .It is associated with foetal growth restriction 1 and may have a role as a potential screening tool in pregnancy 10 . Scientific and clinical interest continues to grow in evaluating the role of arterial stiffness and its association with pregnancy complications and cardiovascular disorders during pregnancy 1,9,11 .…”

Section: Introductionmentioning

confidence: 99%

Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women

Osman

Nath

Khalil

et al. 2017

Pregnancy Hypertension

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“…Several studies have investigated the associations between offspring’s birth weight and maternal peripheral [ 3 , 5 - 17 ] and central blood pressures [ 9 , 13 , 14 ], with inverse relations reported in most studies [ 3 , 5 - 9 , 13 - 17 ], but not all [ 10 - 12 ]. Some studies have also suggested that the relation between maternal central blood pressures and size at birth may be more pronounced than peripheral blood pressures [ 13 , 14 ]. However, very few studies have examined both peripheral and central blood pressures and the sample sizes were small in previous studies [ 9 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The association between maternal blood pressures and offspring size at birth in Southeast Asian women

Lim

Lee

Tan

et al. 2014

BMC Pregnancy Childbirth

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BackgroundMaternal blood pressures in pregnancy is an important determinant of offspring size at birth. However, the relationship between maternal blood pressures and offspring’s size at birth is not consistent and may vary between ethnic groups. We examined the relationship between maternal peripheral and central blood pressures and offspring size at birth in an Asian multi-ethnic cohort, and effect modifications by maternal ethnicity and obesity.MethodsWe used data from 713 participants in the Growing Up in Singapore Towards Healthy Outcomes study consisting of pregnant Chinese, Malay and Indian women recruited from two tertiary hospitals between 2009 to 2010. Peripheral systolic and diastolic blood pressures (SBP and DBP), and central SBP and pulse pressure (PP) were measured around 27 weeks of gestation. Biometric parameters at birth were collected from medical records.ResultsAfter adjusting for maternal and fetal covariates, each 1-SD increase (10.0 mmHg) in central SBP was inversely associated with birth weight (−40.52 g; 95% confidence interval (CI) -70.66 to −10.37), birth length (−0.19 cm; −0.36 to −0.03), head circumference (−0.12 cm; −0.23 to −0.02) and placental weight (−11.16 g; −20.85 to −1.47). A one-SD (11.1 mmHg) increase in peripheral SBP was also associated with lower birth weight (−35.56 g; −66.57 to −4.54). The inverse relations between other blood pressure measures and offspring size at birth were observed but not statistically significant. Higher peripheral SBP and DBP and central SBP were associated with increased odds of low birth weight (defined as weight <2500 g) and small for gestational age (defined as <10th percentile for gestational age adjusted birth weight). Maternal adiposity modified these associations, with stronger inverse associations in normal weight women. No significant interactions were found with ethnicity.ConclusionsHigher second-trimester peripheral and central systolic pressures were associated with smaller offspring size at birth, particularly in normal weight women. Findings from this study reinforces the clinical relevance of antenatal blood pressure monitoring.Electronic supplementary materialThe online version of this article (doi:10.1186/s12884-014-0403-1) contains supplementary material, which is available to authorized users.

show abstract

Maternal arterial stiffness in normotensive pregnant women who subsequently deliver babies that are small for gestational age

Cited by 17 publications

References 36 publications

Longitudinal study of vascular structure and function during normal pregnancy

Longitudinal study of vascular structure and function during normal pregnancy

Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women

The association between maternal blood pressures and offspring size at birth in Southeast Asian women

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