Maternal antigenic stimulation actively produces suppressor activity in offspring

Koshimo, Hiroyuki; Miyazawa, Yumiko; Shimizu, Yukio; Yamaguchi, Nobuo

doi:10.1016/0145-305x(89)90020-7

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…It was inevitable that the collapse of the suppressor T‐cell field would affect the study of their role in maternal‐fetal tolerance, as it ailed from the same faults, the use of CD8 as a marker for suppressor T cells 55,56 , suppressor cell circuits 79 and I‐J as a marker 80 . Thus it is not surprising, that papers challenging the role of T cells in the control of anti‐fetal responses soon appeared 81,82 .…”

Section: A Difficult Birth: the Role Of Regulatory T Cells In Maternamentioning

confidence: 99%

Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells

Terness

Kallikourdis

Betz

et al. 2007

American J Rep Immunol

110

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A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.

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Section: A Difficult Birth: the Role Of Regulatory T Cells In Maternamentioning

confidence: 99%

Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells

Terness

Kallikourdis

Betz

et al. 2007

American J Rep Immunol

110

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“…In addition to the MDA-mediated effects on neonatal immunocompetence in the mouse, Fujii and Yamaguchi (1992) reported that immunization of pregnant mice induced CD4 + T lymphocytes which were capable of either producing a suppressive factor themselves or stimulating a population of T suppressor cells to secrete such a factor that could cross the placenta and induce specific humoral and cellular immunosuppression in the neonate. One of the authors has also previously reported the induction in mice of suppressor T cells in offspring following maternal immunization (Koshimo et al, 1989). Imnaunocompetent cells and various factors are absorbed by the gut during the first 36 h of life in the domesticated species and, therefore, it is possible that these may have a regulato~ T effect on the immature immune system in these species similar to the transplacental factors in mice (Palmerly & Beer, 1977).…”

Section: Experimental Evidencementioning

confidence: 99%

The interference by maternally-derived antibody with active immunization of farm animals against foot-and-mouth disease

Kitching

Salt

1995

British Veterinary Journal

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Foot-and-mouth disease (FMD) is a highly contagious disease affecting ruminants and pigs. In countries in which control of FMD relies predominantly on vaccination, young stock ingest specific anti-FMD virus antibodies in the colostrum. This maternally-derived antibody (MDA) provides immediate protection against infection with FMD virus, but also interferes with the development of active immunity following vaccination. However, susceptibility to infection precedes the ability to respond to vaccination in the presence of MDA. Currently available vaccines cannot overcome this inhibitory effect of MDA, and protection of young stock can only be provided by their isolation from FMD virus.

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“…Immune suppression is usually attributed to CD8 positive or so called suppressor cells [38][39][40][41][42][43][44][45][46]. In this suppression system, the effector cells were identified by the adoptive transfer system.…”

Section: Adoptive Transfer Of Effector Cells In This Suppressionmentioning

confidence: 99%

Maternal Bias of Immunity to Her Offspring: Possibility of an Autoimmunity Twist out from Maternal Immunity to Her Young

Yamaguchi¹,

Takei

Chen³

et al. 2013

OJRA

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The major interest in materno-foetal relation is why fetus is not rejected by the mother, even in a different genetic background. But in this article we have been investigating about the effect(s) of maternal antigenic stimulation or infection upon the active immune responses in her offspring. The results of various researchers have certainly pose significant problems as to the defense of infants against infectious agents, especially those introduced by their mothers. But we have already reported that maternal antigenic stimulation greatly suppresses the specific immune response of the offspring in a system of mouse vs heterologous erythrocytes and other T-dependent antigens. This suppression was antigen specific and effective on 1/6 life of rodents. The mechanisms that concerned in this suppression were not antigen administered nor antibody produced in the mother. The supporting evidences were that this suppression was MHC restricted and limited in during pregnancy for induction between mother and her young. The system examined was separating genetic backgrounds that the haplotype was different in F2 family where half of the young were identical but not in remainder to the F1 mother mouse. From this backcross system, this suppression was MHC restricted, suggesting cell to cell contact with mother to her young. Moreover, cytokine level in both mother and her young, IFN- levels was up-regulated in such a young whose mother was immunized with antigen. The significance of this phenomenon were accessed as biological and medical intervention especially for the mother and infant health care and prevention of hypersensitivities, autoimmune syndrome for her young after delivery.

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Maternal antigenic stimulation actively produces suppressor activity in offspring

Cited by 13 publications

References 16 publications

Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells

Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells

The interference by maternally-derived antibody with active immunization of farm animals against foot-and-mouth disease

Maternal Bias of Immunity to Her Offspring: Possibility of an Autoimmunity Twist out from Maternal Immunity to Her Young

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