Maternal Antibodies and Neonatal Thrombocytopenia

Mickley, Hans; Diederichsen, Hans; Grunnet, Niels

doi:10.1016/s0140-6736(82)91655-5

Cited by 8 publications

(2 citation statements)

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“…Both mothers in our families were HLA-B8 positive. In recent reports this very interesting, obviously strong association between HLA-BS and PIA' immunization has been shown (26,28). The affected children might require platelet transfusions, and PIA' negative platelets are the ideal choice.…”

Section: Discussionmentioning

confidence: 97%

“…Platelets have ABO antigens, and the problem whether ABO incompatibility influences PIA1 immunization, as in Rh(D) immunization, has been the subject of controversial reports (6, 26,27). The affected children in our families were all ABO compatible with their mothers, but there are reports where affected children have been incompatible with their mothers, also the immunizing child (6, 26).…”

Section: Discussionmentioning

confidence: 99%

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Neonatal Alloimmune Thrombocytopenia

Brockmeier

Nordhagen²,

Finne

1983

Acta Paediatrica

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Two families are presented, where the mothers have given birth to children with neonatal alloimmune thrombocytopenia (NAITP) due to immunization towards the platelet specific antigen PIA1, which is responsible for most of the cases with NAITP. Anti-PIA1 has previously been difficult to demonstrate, but current techniques, such as the platelet suspension immunofluorescence test (PSIFT) used here, have made routine laboratory diagnosis possible. Both mothers in these families were HLA-B8 positive. This antigen shows strong association with PIA1 immunization.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%