Maternal Anti-Ro/SSA and Anti-La/SSB Antibodies and Fetal Congenital Heart Block

Hypergammaglobulinemic Purpura of Waldenstrom (HGPW) in Pregnancy: A Rare Case Report

“…She was diagnosed with anti-Ro, Lapositive HGPW [6]. Three cases reported by Kapur et al in 2014 had positive anti-Ro (SSA) and anti-La (SSB) in pregnancy and were diagnosed with congenital heart block in fetus at various period of gestation [3].…”

“…Regular and close monitoring for heart block and transplacental therapy with fluorinated steroids (dexamethasone) has shown satisfactory results at first evidence of heart block, and it is beneficial in first-and second-degree heart block, but once fetal third-degree block is detected, it is irreversible regardless of treatment. Prophylactic therapy is not currently indicated as they may have maternal and fetal side effects like osteoporosis, osteonecrosis, diabetes, hypertension, premature rupture of membranes, adrenal insufficiency of the fetus, intrauterine growth restriction (IUGR) and oligohydramnios [3,4]. The etiology of the disorder is not clear, however, on skin biopsy; a leukocytoclastic vasculitis is usually seen.…”

Systemic lupus erythematosus and preconception care

“…But circumstantial evidence has shown that placental transfer of these anti bodies occur during the second trimester and mediates immunological injuries to the fetalheart and the conduction system Once complete heart block is established, it is irreversible. 21,22 Copyright: ©2020 Kaur Citation: Kaur B. Systemic lupus erythematosus and preconception care.…”