Maternal Anemia in Pregnancy: Assessing the Effect of Routine Preventive Measures in a Malaria-Endemic Area

Ouédraogo, Smaïla; Koura, Kobto Ghislain; Bodeau-Livinec, Florence; Massougbodji, Achille; Cot, Michel

doi:10.4269/ajtmh.12-0195

Cited by 42 publications

(41 citation statements)

References 35 publications

(46 reference statements)

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“…It usually results due to the normal physiological changes of pregnancy resulting in hemoglobin concentration [6, 11]. The problem is more common in developing countries where there is inadequate diet and poor prenatal vitamins and iron and folic acid intake [1, 6, 12]. The most common type of anemia is iron deficiency anemia which mainly affects women of reproductive age group, particularly pregnant women [4, 13].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of anemia among pregnant women in Ethiopia; a systematic review and meta-analysis

et al. 2017

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BackgroundAnemia during pregnancy is one of the most common indirect obstetric cause of maternal mortality in developing countries. It is responsible for poor maternal and fetal outcomes. A limited number of studies were conducted on anemia during pregnancy in Ethiopia, and they present inconsistent findings. Therefore, this review was undertaken to summarize the findings conducted in several parts of the country and present the national level of anemia among pregnant women in Ethiopia.MethodsPreferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed for this systematic review and meta-analysis. The databases used were; PUBMED, Cochrane Library, Google Scholar, CINAHL, and African Journals Online. Search terms used were; anemia, pregnancy related anemia and Ethiopia. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was used for critical appraisal of studies. The meta-analysis was conducted using STATA 14 software. The pooled Meta logistic regression was computed to present the pooled prevalence and relative risks (RRs) of the determinate factors with 95% confidence interval (CI).ResultsTwenty studies were included in the meta-analysis with a total of 10, 281 pregnant women. The pooled prevalence of anemia among pregnant women in Ethiopia was 31.66% (95% CI (26.20, 37.11)). Based on the pooled prevalence of the subgroup analysis result, the lowest prevalence of anemia among pregnant women was observed in Amhara region, 15.89% (95% CI (8.82, 22.96)) and the highest prevalence was in Somali region, 56.80% (95% CI (52.76, 60.84)). Primigravid (RR: 0.61 (95% CI: 0.53, 0.71)) and urban women (RR: 0.73 (95% CI: 0.60, 0.88)) were less likely to develop anemia. On the other hand, mothers with short pregnancy interval (RR: 2.14 (95% CI: 1.67, 2.74)) and malaria infection during pregnancy (RR: 1.94 (95% CI: 1.33, 2.82)) had higher risk to develop anemia.ConclusionsAlmost one-third of pregnant women in Ethiopia were anemic. Statistically significant association was observed between anemia during pregnancy and residence, gravidity, pregnancy interval, and malaria infection during pregnancy. Regions with higher anemia prevalence among pregnant women should be given due emphasis. The concerned body should intervene on the identified factors to reduce the high prevalence of anemia among pregnant women.Electronic supplementary materialThe online version of this article (10.1186/s12878-017-0090-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of anemia among pregnant women in Ethiopia; a systematic review and meta-analysis

et al. 2017

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“…Merozoites floating in the blood stream randomly collide and bind with RBCs [51]. The binding of merozoites and RBC occur through interaction between merozoites surface protein 1 (MSP-1) and Band 3 on RBC [8].…”

Section: Malaria Induced Anemia (Mia) In Pregnancymentioning

confidence: 99%

“…Different species of malaria parasite release different antigen to facilitate binding. For instance, P. falciparum releases Erythrocyte Binding Antigen-175 (EBA-175) [51], a microneme protein which binds to the sialic acid residue on glycophorins of the RBCs [55]. A merozoite serine protease cleaves band 3, causing a disruption in the cytoskeleton of RBC.…”

Section: Malaria Induced Anemia (Mia) In Pregnancymentioning

confidence: 99%

“…A merozoite serine protease cleaves band 3, causing a disruption in the cytoskeleton of RBC. This results in mechanical destruction of the RBC through haemolysis [51]. The AMA-1 also releases coats the surface of non-parasitized RBCs and are cleared by the immune system [55,51].…”

Section: Malaria Induced Anemia (Mia) In Pregnancymentioning

confidence: 99%

“…This results in mechanical destruction of the RBC through haemolysis [51]. The AMA-1 also releases coats the surface of non-parasitized RBCs and are cleared by the immune system [55,51]. Again, the antigens act to down regulate erythropoiesis, and the cumulative effect of these activities seeks to reduce the quantity of RBCs leading to anaemia [48].…”

Section: Malaria Induced Anemia (Mia) In Pregnancymentioning

confidence: 99%

See 2 more Smart Citations

Effects of Malaria in Pregnancy (MiP) on Pregnancy Development and its Outcome: a Critical Review

Djabanor¹,

Quansah²,

DuBois³

2017

J App Biol Biotech

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Malaria is the most important tropical parasitic infection in humans all over the world, and very common in developing countries especially in the tropical zones. The protozoan parasites Plasmodium falciparum, P. vivax, P. malariae and P. ovaleare transmitted through the bite of sporozoite-infected female Anopheles mosquitoes to cause malaria in humans. Malaria in pregnancy (MiP) is a clinical situation in which a pregnant woman is infected with Plasmodium parasite resulting in malaria. MiP is detrimental to both the pregnant woman and her fetus, and it remains as one of the major causes of infant mortality in malaria endemic regions especially in Sub-Saharan Africa. It causes several histopathological changes within the placenta and umbilical cord which manifest in several clinical symptoms. It is one of the key contributors to preterm delivery, low birth weight, intrauterine growth retardation (IUGR), miscarriage, intrauterine death, poor neurodevelopment and immunosuppression in infants. Most distinct systemic proinflammatory responses in pregnancy are characteristics of severe malaria, and excessive activation of the immune system is central to the pathophysiology of placental malaria. There is extensive research on VAR2CSA and its contribution to placental sequestration. Currently, VAR2CSA protein is being made into pregnancy malaria specific vaccines for non-immune mothers to reduce placental malaria infection. This review summarizes the evidences, currently known clinically significant manifestations and the ultimate effect of MiP on pregnancy development.

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Improving blood transfusion services

Tancred

Bates

2019

Best Practice & Research Clinical Obstetrics & Gynaecol

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Maternal Anemia in Pregnancy: Assessing the Effect of Routine Preventive Measures in a Malaria-Endemic Area

Cited by 42 publications

References 35 publications

Prevalence and determinants of anemia among pregnant women in Ethiopia; a systematic review and meta-analysis

Prevalence and determinants of anemia among pregnant women in Ethiopia; a systematic review and meta-analysis

Effects of Malaria in Pregnancy (MiP) on Pregnancy Development and its Outcome: a Critical Review

Improving blood transfusion services

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