Maternal and perinatal outcomes of pregnant women with SARS‐CoV‐2 infection

Abstract

Despite the increasing number of published studies, objective evidence is still needed to draw any conclusion on the course of SARS-COV-2 infection acquired during pregnancy. What are the clinical implications of this work? The study showed that in pregnancies complicated by SARS-COV-2, the risk of maternal mortality was 0.8%, but about 11% of women required admission to ICU. Pregnancies affected by SARS-COV-2 were also complicated by 23% rate preterm birth, and 4.1% rate of perinatal death. The risk of vertical transmission was negligible.

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19

“…11.1% of women were admitted to ICU, and 6.4% requiring intubation. There were three cases of maternal deaths, accounting for a maternal mortality rate of 0.8% [12].…”

“…This is a secondary analysis of the World Association of Perinatal Medicine (WAPM) study [12]. The WAPM study was a multinational, cohort study on all consecutive pregnant women with laboratoryconfirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries (Argentina, Australia, Belgium, Brazil, Colombia, Czech Republic, Finland, Germany, Greece, Israel, Italy, North Macedonia, Peru, Portugal, Republic of Kosovo, Romania, Russia, Serbia, Slovenia, Spain, Turkey, and United States) COVID-19 was diagnosed on the basis of The World Health Organization (WHO) interim guidance [13].…”

“…We have recently shown that COVID-19 in pregnant women is associated with low rate of maternal mortality, but 11.1% rate of admission to ICU. Furthermore, earlier gestational age at presentation, shortness of breath as presenting symptom, and increased lactate dehydrogenase (LDH) levels were independently associated with composite adverse maternal outcome including either admission to intensive care unit, use of mechanical ventilation or death [12].…”

“…In a large multinational cohort study, we have recently shown that COVID-19 in pregnant women is associated with low rate of maternal mortality, but 11.1% rate of admission to intensive care unit (ICU) [12].…”

Perinatal mortality and morbidity of SARS-COV-2 infection during pregnancy in European countries: Findings from an international study

“…Here we present a secondary analysis on perinatal mortality and morbidity in European compared with non-European pregnant women involved in one of the largest retrospective cohort studies on COVID-19 during pregnancy [7,8]. This was a multinational, retrospective cohort study that included all pregnant women with a laboratory-COnfirmed SARS-COV-2 infection, diagnosed between February 1, 2020 and April 30, 2020, in 72 centers from 22 different countries in Europe, Asia, North and South America and Australia (Argentina, Australia, Belgium, Brazil, Colombia, Czech Republic, Finland, Germany, Greece, Israel, Italy, North Macedonia, Peru, Portugal, Republic of Kosovo, Romania, Russia, Serbia, Slovenia, Spain, Turkey, and United States) [7]. All infected women were diagnosed antepartum during pregnancy, on the basis of The World Health Organization (WHO) interim guidance [9] (a confirmed case of SARS-COV-2 was defined as a positive result on real-time reverse-transcriptasepolymerase-chain-reaction assay of nasal and pharyngeal swab specimens) [10,11].…”