Maternal and perinatal outcome in pregnancy induced hypertension and preeclampsia

Pairu, Jagannath; Kn, Bharathi; George, K

doi:10.18203/2320-1770.ijrcog20162085

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…preterm). 17,30 In present study we found that percentage of IUD baby (12.5%) and NICU admission (37.5%) in hypertensive cases were more as compare to percentage of IUD baby (3.8%) and NICU-admission 12.5% in normotensive cases, with p value 0.001 which was statistically significant indicated that there was statistically significant association between poor perinatal outcome and HDP. Uddin AW, Nessa S, et al in their study found that there was a significant association between hypertensive disorders and poor perinatal outcome (p=0.015).…”

Section: Delivery Outcomesupporting

confidence: 51%

Study of significance of elevated maternal serum β-human chorionic gonadotropin (β-hCG) level in 16 to 20 weeks pregnant women as predictor of hypertensive disorder of pregnancy

Pawar

Goyal

Kaur

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertensive disorder of pregnancy affects both mother and fetus, leading their high morbidity and mortality and a major killer of women in developing country. The etiologic of preeclampsia is still not clear. It seems that placenta plays main role in path-physiology of preeclampsia, but there is strict relationship between hypertensive disorder of pregnancy and elevated β-hCG level, indicating there should be an abnormal placental secretary function in patients with severe preeclampsia.Methods: 245 patients were recruited from our institute (OPD) and Prospective analytical study was started with 16-20 weeks pregnant women. Cases were subjected to detailed history and thorough physical examination including baseline blood pressure. β-hCG measurement was done between 16-20 weeks and cases were followed at regular interval for the development of hypertensive disorder of pregnancy. Statistical testing was conducted with appropriate tests.Results: Total 245 women were enrolled in the study, only 208 were followed till delivery, 24 were developed hypertension. On analysis of data, maximum cases were younger, primigravida and of lower class. β-hCG levels (Mean ± SD) were also significantly higher (30100±16250 V/S 74700±23790; p<0.001) in subjects who later developed hypertension. Cut off value of β-hCG was 45755 mIU/ml, and analysis establishes validity of β-hCG as predictor of hypertensive disorder of pregnancy with sensitivity, specificity, positive and negative predictive value for β hCG were 87.5, 83.2, 70.4 and 83.7% respectively.Conclusions: Present study shows that elevated serum β-hCG in early second trimester can be considered as predictor of subsequent hypertensive disorder of pregnancy.

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Section: Delivery Outcomesupporting

confidence: 51%

Study of significance of elevated maternal serum β-human chorionic gonadotropin (β-hCG) level in 16 to 20 weeks pregnant women as predictor of hypertensive disorder of pregnancy

Pawar

Goyal

Kaur

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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“…Pairu et al in their study reported that fetal outcome, pre-term deliveries, fetal growth retardation (IUGR) and still birth was significantly more frequent in women with preeclampsia as compared to those without pregnancy induced hypertension. 25 Limitation of present study was that it was observational study without control subject. We also not classified patients in different categories.…”

Section: Discussionmentioning

confidence: 91%

“…In present study, out of 90 pregnant patients, 58% were in age group of [25][26][27][28][29][30][31][32][33][34][35] year and 57% patients were primigravida. Solange et al and Patel et al also reported most common age group was 20-34 year (64%) and [18][19][20][21][22][23][24][25][26] year (56%) respectively. 15,16 In present study, mean systolic blood pressure of pregnancy induced hypertensive patients was 148+3.8 mmHg and mean diastolic blood pressure was 95+1.4 mmHg.…”

Section: Discussionmentioning

confidence: 99%

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Biochemical parameter and feto-maternal outcome in preeclampsia: a hospital based observational study

Nagar¹,

Nagar²,

Gupta³

2018

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONPregnancy is a physiological phenomenon for most women. However, some develop problems during its evolution, putting both the mothers and the conceptus health at sake. Hypertensive disorders of pregnancy (HDPs) are one of the maternal diseases that cause detrimental effects on to the maternal, fetal, and neonatal health. The hypertensive disorders of pregnancy (HDPs) complicate about 3-10% of pregnancies. 1 They are one of the major contributors to maternal and fetal mortality and morbidity globally; maternal complications include eclampsia, stroke, and damage to the hepatic and renal organs etc. 2 Hypertension diseases during pregnancy includes pregnancy-induced hypertension (PIH) (without proteinúria), pre-eclampsia (with proteinuria), and eclampsia (pre-eclampsia with convulsions). Pregnancy termination reverses the clinical manifestations of the disease, suggesting that trophoblastic invasion has a central role in the pathogenesis of preeclampsia. 3 A recent study revealed that excessive placental secretion of soluble fms-like tyrosine kinase-1 may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. 3 In a multicenter study, approximately 30% of HDP cases were due to chronic hypertension, while 70% were due to gestational hypertension/preeclampsia. 4 ABSTRACT Background: Preeclampsia is one of the maternal diseases that cause detrimental effects on to the maternal, fetal, and neonatal health. The objective of the present study was to analyse maternal, perinatal outcome and investigation parameter in preeclampsia. Methods: This is an observational study and total of 90 consecutive patients were enrolled who has blood pressure ≥ 140/90 mmHg after 20 weeks of gestation with proteinuria (1+ by dipstick). Results: Among enrolled patients, 52 (58%) were in age group of 25-35 year and 51 (57%) were primigravida. Mean systolic and diastolic blood pressure of patients was 148±3.8 mm of Hg and 95±1.4 mm of Hg respectively. Most common presenting symptom was labor pain in 65 (72%) patients followed by edema in 61 (68%) patients. Most common complication was CNS symptom including seizure (Eclampsia) in 13 (15%) patients followed by vaginal bleeding (including abruption) in 12 (13%) patients. Mean hemoglobin level was 9.12±0.9 gm/dl. Mean urea and creatinine values were 34±4.6 mg/dl and 1.5±1.1 mg/dl respectively. Out of total 90 patients, 18 (20%) had elevated liver enzymes. Most common neonatal outcome was low birth weight 63 (70%) and 40 (44%) were preterm. APGAR score was less than 7 in 11 (12%) patients and more than 7 in 79 (88%) patients. Five (5.5%) newborn were still born. Conclusions: Preeclampsia is associated with multiple maternal and neonatal complications. Hence, there is a need for regular antenatal checkup to detect early and strengthening of neonatal intensive care units.

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“…Hypertension is one of the common medical complications of pregnancy known to increase the risk of maternal and perinatal morbidity and mortality 1 . Hypertensive disorders of pregnancy include chronic hypertension, gestational hypertension, pre-eclampsia, eclampsia and chronic hypertension with superimposed pre-eclampsia.…”

Section: Introductionmentioning

confidence: 99%

Maternal and Perinatal Outcome in Hypertensive Disorders of Pregnancy - A Retrospective Study

Joshi

Kathaley

Borade

et al. 2018

MVP Journal of Medical Sciences

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Background: It was a retrospective observational study to know demographic factors, maternal and perinatal outcome in patients of hypertensive disorders of pregnancy admitted in a medical college and tertiary health care center. Introduction: Hypertensive disorders of pregnancy are one of the important cause of maternal morbidity and mortality in India. Hypertensive Disorders of Pregnancy (HDP) account for nearly 18% of all maternal deaths worldwide. Delivery at early gestational age in patients of HDP is associated with high perinatal morbidity and mortality resulting from prematurity. Method: Total number of 120 cases of hypertensive disorders of pregnancy admitted in our hospital was included in the study after satisfying inclusion and exclusion criteria. We studied demographic factors as well as maternal and perinatal outcome. Results: Majority of the patients i.e. 40% were in the age group of 21-30 yrs. 61% of patients were primi gravida and 25% of patients were second gravida. Maximum number of patients had gestational age ≥ 32weeks at the time of delivery. 26.6% patients, 73.4% patient's and 12.5% patients were diagnosed as gestational hypertension, preeclampsia and eclampsia respectively. There was high incidence of HELLP and eclampsia in 12.5% each, DIC in (5%), APH in (4.1%), renal complications in (3.3%) and CNS complication were seen in 0.8%. 67.5% patients were delivered by vaginal route, 32.50% patients required LSCS. Majority of patients i.e., 60% underwent preterm delivery, 34% delivered at term. Maternal mortality occurred in 8 patients (6.67%). HELLP and DIC were the leading causes of death. 70% patients had good perinatal outcome. There were 25.83% still births and 4.17% neonatal deaths. Conclusion: Hypertensive disorders of pregnancy are associated with increased maternal and perinatal morbidity and mortality. Good antenatal care, health education, early diagnosis, early referral to higher center and multidisciplinary approach will reduce morbidity and mortality in mother and baby.

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Maternal and perinatal outcome in pregnancy induced hypertension and preeclampsia

Cited by 5 publications

References 6 publications

Study of significance of elevated maternal serum β-human chorionic gonadotropin (β-hCG) level in 16 to 20 weeks pregnant women as predictor of hypertensive disorder of pregnancy

Study of significance of elevated maternal serum β-human chorionic gonadotropin (β-hCG) level in 16 to 20 weeks pregnant women as predictor of hypertensive disorder of pregnancy

Biochemical parameter and feto-maternal outcome in preeclampsia: a hospital based observational study

Maternal and Perinatal Outcome in Hypertensive Disorders of Pregnancy - A Retrospective Study

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