Maternal and paternal obesity are associated with offspring obestatin levels in the Nutritionists’ Health Study

Freitas, Renata Germano Borges de Oliveira Nascimento; Vasques, Ana Carolina Junqueira; Ribeiro, Fernanda; Solar, Isabela; Hanada, Alfredo Shigueo; Barbosa, Marco António; Valente, Angelica; Almeida-Pititto, Bianca de; Lopes, Tito Lívio da Cunha; Geloneze, Bruno; Ferreira, Sandra Roberta Gouvêa

doi:10.1016/j.nut.2020.111067

Cited by 5 publications

(7 citation statements)

References 43 publications

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“…Due to evident timing and ethical issues, human studies investigating these aspects are limited and varied; thus, this systematic review was carried out in order to summarize the state-of-the-art findings. The majority of included studies [22][23][24][27][28][29][30][31] considered BMI as paternal parameter on varying offspring outcomes. Four studies studied cord blood DNA methylation, all of which showed the impact of higher paternal BMI on DNA methylation of different genes.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, one study reported a significantly smaller infant triceps, suprailiac, and thigh skinfold thickness measurement, as well as percent fat mass, in offspring of fathers with a BMI >35 compared with that observed in offspring of lean fathers [22]. Finally, offspring obestatin and visfatin levels, a gut hormone that acts as an anorexigenic hormone and a marker associated to obesity and other diseases linked by inflammation and insulin resistance such as type 2 diabetes mellitus and cardiovascular disease, respectively, were evaluated in relation to paternal BMI [24]. Obestatin levels was inversely associated with maternal BMI (β=−0.03; P=0.045) and paternal BMI (β=−0.02; P=0.048), after adjustment for maternal and paternal education, maternal age and maternal tobacco, alcohol and/or drugs use, while no association was detected with visfatin levels [24].…”

Section: Discussionmentioning

confidence: 99%

“…After removing 1138 papers through the title/abstract screening, 19 were retrieved as full text. Of the 19 full text, seven studies were excluded because paternal data were not antenatal but referred to the time of the study, leaving 12 studies to be included in this systematic review [20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Literature Searchmentioning

confidence: 99%

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Paternal nutrition: a neglected periconceptual influence on offspring health

Pizzol,

Gibson,

Muhelo

et al. 2023

Nutrire

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Increasing evidence suggests that paternal nutrition and nutritional status are potentially associated with offspring health. However, its specific configuration in the wider concept of trans-generational linkage and how it fits with genetic, epigenetic and environmental factors is unclear. Thus, the aim of this systematic review was to assess the effects of paternal nutrition or nutritional status on offspring health. This systematic review included 12 studies and a total of 8658 fathers and relative children. Paternal body mass index (BMI) was significantly related with cord blood DNA methylation, birthweight and obesity in offspring at follow-up, anthropometric measurements and obestatin and visfatin levels. Only one study investigated and showed an association between paternal river fish diet and lower risk of autism spectrum disorder. No association was reported in single studies between paternal intake of caffeine, folate vitamins B6 and B12 and offspring health outcomes. Limited data suggests that paternal nutrition and nutritional status are associated with components of offspring health. Considering this emerging concept, it is mandatory to reconsider the approach to fertility and offspring wellbeing, including fathers as a pivotal element. It is urgent to better understand how the male factor impacts couple fertility and offspring health outcomes. It is also crucial to ensure that, at conception, the father, as well as the mother, considers nutritional and lifestyle factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Paternal nutrition: a neglected periconceptual influence on offspring health

Pizzol,

Gibson,

Muhelo

et al. 2023

Nutrire

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“…An interesting finding of our group previously suggested that breastfeeding duration could influence the offspring’s adherence to a prudent dietary pattern and metabolic parameters in adulthood ( Eshriqui et al., 2019 ; Eshriqui et al., 2020 ). Another latent factor that could underlie the microbiota variability is the maternal and paternal BMI before conception ( Eshriqui et al., 2021 ; Freitas et al., 2021 ), but, according to the PERMANOVA adjustments, there was no association between these maternal variables and the offspring’s microbiota structure.…”

Section: Discussionmentioning

confidence: 99%

Associations of Blautia Genus With Early-Life Events and Later Phenotype in the NutriHS

Freitas

Vasques

Fernandes

et al. 2022

Front. Cell. Infect. Microbiol.

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IntroductionEarly-life events are associated with the risk of obesity and comorbidities later in life. The gut microbiota—whose composition is influenced by genetics and environmental factors—could be involved. Since the microbiota affects metabolism and fat storage, early-life insults could contribute to the occurrence of obesity driven, in part, by microbiota composition. We examined associations of gut bacteria with early-life events, nutritional status, and body composition in the Nutritionist’s Health Study (NutriHS).MethodsA cross-sectional study of 114 female participants examining early-life data, body composition, and biological samples was conducted. Fecal microbiota structure was determined targeting the V4 region of the 16S rRNA gene. Principal coordinates analysis (PCoA) and permutational multivariate analysis of variance (PERMANOVA) were used to test the impact of variables on microbial diversity. Profiles were identified using the Jensen-Shannon divergence matrix and Calinski–Harabasz index. Differential abundance between the categories of exclusive breastfeeding duration and nutritional status was tested using DESeq2.ResultsIn the sample [median age 28 years and body mass index (BMI) 24.5 kg/m2], 2 microbiota profiles driven by the Blautia or Prevotella genus were identified. An estimated 9.1% of the variation was explained by the profiles (p < 0.001), 2.1% by nutritional status (p = 0.004), and 1.8% by exclusive breastfeeding (p = 0.012). The proportion of participants with BMI <25 kg/m2 and who were breastfed for at least 6 months was higher in the Blautia profile (p < 0.05).ConclusionFindings in a Blautia-driven profile of healthy women reinforce that early-life events play a role in defining gut microbiota composition, confirming the importance of exclusive breastfeeding for infant gut colonization in establishing a protective profile against adiposity-related outcomes in adulthood.

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“…In recent years, a number of human studies have highlighted the association between maternal prepregnancy BMI and BMI of the offspring, 17,18 as well as cardiovascular and metabolic diseases, 2,19,20 suggesting that the time around conception may be a sensitive developmental window with long-lasting effects on the offspring. This has been further strengthened by studies in mice.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of antioxidants on cardiac function in adult offspring exposed to prenatal overnutrition

Zhang

Cao

Huo

et al. 2022

J Dev Orig Health Dis

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Maternal overnutrition-induced fetal programming predisposes offspring to cardiovascular health issues throughout life. Understanding how these adverse cardiovascular effects are regulated at the maternal–fetal crosstalk will provide insight into the mechanisms of these cardiovascular diseases, which will help in further identifying potential targets for intervention. Here, we uncover a role of oxidative stress caused by prenatal overnutrition in governing cardiac damage. Mice exposed to maternal obesity showed remarkable pathological cardiomyocyte hypertrophy (pmale < 0.001, Cohen’s dmale = 1.77; pfemale < 0.001, Cohen’s dfemale = 1.94), increased collagen content (pmale < 0.001, Cohen’s dmale = 2.13; pfemale < 0.001, Cohen’s dfemale = 2.71), and increased levels of transforming growth factor β (TGF-β) (pmale < 0.001, Cohen’s dmale = 3.02; pfemale < 0.001, Cohen’s dfemale = 4.52), as well as left ventricular dysfunction in adulthood. To cope with increased oxidative stress in the myocardial tissue of offspring from obese mothers, we sought to decrease the effect of oxidative stress and prevent the development of these cardiovascular conditions with use of the antioxidant N-acetylcysteine during pregnancy. As predicted, after treatment with the antioxidant, there was greatly mitigated cardiomyocyte hypertrophy (pmale < 0.001, Cohen’s dmale = 1.31; pfemale < 0.001, Cohen’s dfemale = 0.82) and cardiac fibrosis, including decreased composition of collagen fibers (pmale < 0.01, Cohen’s dmale = 1.45; pfemale < 0.05, Cohen’s dfemale = 1.23) and reduced levels of TGF-β (pmale < 0.05, Cohen’s dmale = 1.83; pfemale < 0.01, Cohen’s dfemale = 3.81). We also observed improved left ventricle contractile function together with the alleviation of enhanced oxidative stress in the myocardial tissue of offspring. Collectively, these results established a crucial role of oxidative stress in prenatal overnutrition-associated ventricular remodeling and cardiac dysfunction. Our findings provided an important target for intervention of cardiovascular disease in overnutrition-related fetal programming.

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Maternal and paternal obesity are associated with offspring obestatin levels in the Nutritionists’ Health Study

Cited by 5 publications

References 43 publications

Paternal nutrition: a neglected periconceptual influence on offspring health

Paternal nutrition: a neglected periconceptual influence on offspring health

Associations of Blautia Genus With Early-Life Events and Later Phenotype in the NutriHS

Protective effect of antioxidants on cardiac function in adult offspring exposed to prenatal overnutrition

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