Maternal and Paternal History of Myocardial Infarction and Risk of Cardiovascular Disease in Men and Women

Sesso, Howard D.; Lee, I M; Gaziano, J. Michael; Rexrode, Kathryn M; Glynn, Robert J.; Buring, Julie E.

doi:10.1161/hc2901.093115

Cited by 230 publications

(148 citation statements)

References 24 publications

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“…[1][2][3][4] The mechanisms underlying this familial clustering have not been firmly established but may include an increased susceptibility to atherosclerosis, 5 an increased tendency for thrombosis, 6 and proinflammatory responses suggested by high levels of C-reactive protein. 7 Wang et al 8 recently demonstrated a higher burden of subclinical atherosclerosis as assessed by carotid intimal thickness (IMT) in individuals with a parental history of premature CHD.…”

mentioning

confidence: 99%

Coronary artery calcification and family history of premature coronary heart disease. Sibling history is more strongly associated than parental history

Nasir¹,

Michos²,

Rumberger³

2005

ACC Current Journal Review

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Background-The objective of the study was to assess the association of a family history (FH) of premature coronary heart disease (CHD) with coronary artery calcification (CAC) in asymptomatic individuals and to compare the effects of sibling or parental FH on the risk of subclinical atherosclerosis. Methods and Results-CAC by electron beam tomography was performed in 8549 asymptomatic individuals (69% men; mean age, 52Ϯ9 years). The prevalence and odds of any CAC and extent of CAC stratified according to FH of premature CHD were determined. Those with (1) no FH of CHD, (2) FH of premature CHD in parents, or (3) FH in siblings had a prevalence of CAC of 55%, 64%, and 78% (PϽ0.0001) among men and 27%, 36%, and 56% (PϽ0.0001) among women, respectively. The multivariate regression analysis demonstrated that the odds ratio (95% confidence interval) for the presence of CAC was 1.3 (1.1 to 1.6) among those with positive FH of premature CHD in parents only, 2.3 (1.7 to 3.1) and 2.5 (1.8 to 3.3) among those in siblings and a combined FH compared with those without FH of CHD in men, respectively. Among women, the corresponding odds ratios were 1.3 (1.0 to 1.8), 2.3 (1.7 to 3.6), and 1.9 (1.3 to 3.1), respectively. A similar trend was observed in the association of FH of premature CHD with increasing CAC scores. Conclusions-Our study demonstrates a highly significant association between FH of premature CHD and the presence and extent of CAC. Furthermore, within the limits of self-reporting of family history, our findings suggest that a sibling history is more strongly associated with subclinical coronary atherosclerosis than a parental history of premature CHD.

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mentioning

confidence: 99%

Coronary artery calcification and family history of premature coronary heart disease. Sibling history is more strongly associated than parental history

Nasir¹,

Michos²,

Rumberger³

2005

ACC Current Journal Review

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“…Varios estudios previos han demostrado la relación que existe entre el peso de los individuos al nacer y su riesgo de desarrollar enfermedad coronaria, hipertensión y diabetes en el futuro. Barker et al han propuesto que la adaptación fetal a una nutrición intrauterina inadecuada, debida a insuficiencia placentaria, resulta en la programación de un "fenotipo ahorrador" que permite a los individuos sobrevivir en condiciones de carencia nutricional, pero, una vez estas son superadas y se logra una nutrición adecuada, se incrementa el riesgo de enfermedad coronaria e hipertensión arterial (34). El bajo peso puede explicarse por un parto prematuro o por restricción del crecimiento intrauterino.…”

Section: Discussionunclassified

Factores de riesgo para la enfermedad coronaria temprana en mujeres

Saldarriaga¹,

Franco²,

Garzón³

et al. 2011

biomedica

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Introducción. La enfermedad coronaria es la causa principal de muerte en las mujeres; por esta razón, es prioritario el control del riesgo cardiovascular. Los estudios recientes sugieren una relación entre las alteraciones de la gestación y la enfermedad coronaria; sin embargo, esta hipótesis no ha sido evaluada en la población de mujeres latinoamericanas. Objetivo. Identificar la asociación de riesgo que existe entre la enfermedad coronaria prematura y las alteraciones de la gestación en una población de mujeres colombianas. Materiales y métodos. Es un estudio de casos y controles. Se consideraron casos a las mujeres menores de 55 años sometidas a nueva irrigación quirúrgica o percutánea, y los controles fueron mujeres menores de 55 años con diagnóstico de coronarias sanas por angiografía. Resultados. Se incluyeron 200 pacientes, 100 con coronarias sanas y 100 con enfermedad coronaria, con edad promedio de 46,5±4,3 y 49,5±3,7 años, respectivamente. El análisis univariado mostró asociación entre la enfermedad coronaria y los antecedentes de preeclampsia, partos prematuros, recién nacidos de bajo peso, diabetes mellitus, dislipidemia y tabaquismo. El análisis multivariado mostró persistencia de la asociación con partos pretérmino (OR=6,05; IC95% 2,3-15; p=0,00), dislipidemia (OR=4,09; IC95% 2,1-7,8; p=0,00) y tabaquismo (OR=1,7; IC95% 0,93-3,2; p=0,08). La práctica de actividad física regular se encontró como factor protector (OR=0,5; IC95% 0,27-0,97; p=0,04). Conclusiones. El presente estudio sugiere asociación entre la presencia de enfermedad coronaria prematura y el antecedente de alteraciones de la gestación.Palabras clave: enfermedad coronaria, factores de riesgo, mujeres, complicaciones del embarazo, preeclampsia, trabajo de parto prematuro. Risk factors for premature coronary disease in womenIntroduction. Coronary disease is the leading cause of death in women, and consequently, identification of cardiovascular risk factors must be a priority. Recent studies have linked pregnancy disturbances and coronary disease, but this hypothesis has remained unproved in Hispanic women. Objective. The association of traditional risk factors and pregnancy disturbances with coronary heart disease was assessed in a sample of women with premature coronary disease. Materials and methods. The case control study included only women <55 years old, who had undergone a coronary angiography. Two hundred women were included, 100 without and 100 with coronary disease, and with mean ages of 46.5±4.3 and 49.5±3.7 years, respectively. Logistic regression analysis was used to assess the relationship between risk factors and coronary disease. Crude and multivariate adjusted odds ratios with 95% confidence intervals were calculated. Results. Univariate analysis showed an association between coronary disease and the past medical history of preeclampsia, premature delivery, low birth weight, diabetes, hypercholesterolemia and smoking habit. Logistic regression analysis showed an association of premature delivery (OR=6.0, 95%CI 2.3-15.0, p<...

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“…5 In multiple prospective studies involving hundreds of thousands of men and women, a parental history of premature CHD is a significant risk factor for CVD even after multivariable adjustment. Relative risk estimates generally range from 1.2 to 2.0, as noted in the Physician's Health Study and Women's Health Study, 6 although the estimated magnitude of risk associated with early-onset parental disease is substantially higher in some studies. 7 However, what has remained unclear are the pathophysiological/genetic mechanisms of the familial risk, the extent to which familial risk is independent of other established risk factors (including hyperlipidemia, hypertension, and tobacco use, which have a familial component), the magnitude of excess risk after adjustment for other risk factors, and the extent to which risk conferred by a positive family history of CHD is modifiable.…”

Section: See P 2150mentioning

confidence: 96%

Family History, Subclinical Atherosclerosis, and Coronary Heart Disease Risk

O’Donnell

2004

Circulation

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ith completion of the human genome sequence, expectations are rising that a detailed catalogue will soon be available of all important common genetic susceptibility variants for human diseases, including coronary heart disease (CHD) and related atherosclerotic cardiovascular disease (CVD). 1 In light of this seminal event in medical research, it is curious that the family history of CHD has not been accorded a more central role in risk prediction and disease prevention by clinicians and public health professionals. A positive family history of CHD is present in the majority of cases of premature-onset CHD. 2 In cases of familial hypercholesterolemia and other rare forms of premature-onset CVD, CHD clearly segregates in a mendelian fashion. For most cases of premature-onset CHD, the mode of genetic transmission in families is less clear. Although the family history of CHD has been considered a putative risk factor for decades, it has not been incorporated along with other established risk factors such as hyperlipidemia, hypertension, and cigarette smoking in some widely applied multivariable risk algorithms, 3 though other risk algorithms do incorporate family history information. 4 See p 2150This cautious approach to widespread application of family history information is not due to insufficient evidence. Risks for CHD death are greatest in monozygotic (identical) compared with dizygotic (nonidentical) twins, particularly when there is a premature (eg, Ͻ65 years) age of onset in the initially affected twin. 5 In multiple prospective studies involving hundreds of thousands of men and women, a parental history of premature CHD is a significant risk factor for CVD even after multivariable adjustment. Relative risk estimates generally range from 1.2 to 2.0, as noted in the Physician's Health Study and Women's Health Study, 6 although the estimated magnitude of risk associated with early-onset parental disease is substantially higher in some studies. 7 However, what has remained unclear are the pathophysiological/genetic mechanisms of the familial risk, the extent to which familial risk is independent of other established risk factors (including hyperlipidemia, hypertension, and tobacco use, which have a familial component), the magnitude of excess risk after adjustment for other risk factors, and the extent to which risk conferred by a positive family history of CHD is modifiable.In this context, Nasir et al 8 in this issue of Circulation provide a fascinating and timely contribution to the family history literature. The authors examined the association of a reported family history of early-onset (before age 55 years) CHD with the presence and burden of coronary artery calcium (CAC) in electron beam computed tomography in 8549 asymptomatic men and women referred for testing. 8 CAC is a surrogate measure of the presence and burden of coronary atherosclerosis that has consistently been associated with increased risks for CHD in selected cohorts. 9 CAC was significantly more common in subjects with a sibling or parenta...

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Maternal and Paternal History of Myocardial Infarction and Risk of Cardiovascular Disease in Men and Women

Abstract: Background-Few studies have examined the effects of paternal and maternal history of myocardial infarction (MI)

Cited by 230 publications

References 24 publications

Coronary artery calcification and family history of premature coronary heart disease. Sibling history is more strongly associated than parental history

Coronary artery calcification and family history of premature coronary heart disease. Sibling history is more strongly associated than parental history

Factores de riesgo para la enfermedad coronaria temprana en mujeres

Family History, Subclinical Atherosclerosis, and Coronary Heart Disease Risk

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