Maternal and paternal ages at conception of index child and risk of childhood acute leukaemia: A multicentre case-control study in Greater Mexico City

Jiménez‐Hernández, Elva; Duarte-Rodríguez, David Aldebarán; Núñez-Enríquez, Juan Carlos; Flores-Lujano, Janet; Martín-Trejo, Jorge Alfonso; Espinoza-Hernández, Laura Eugenia; Arellano‐Galindo, José; Medina-Sansón, Aurora; García-Jiménez, Xochiketzalli; Paredes‐Aguilera, Rogelio; Flores-Villegas, Luz Victoria; Peñaloza-González, José Gabriel; Torres-Nava, José Refugio; Espinosa-Elizondo, Rosa Martha; Amador-Sánchez, Raquel; Dosta-Herrera, Juan José; Mondragón-García, Javier Anastacio; Valdés-Guzmán, Heriberto; Mejía-Pérez, Laura; Espinoza-Anrubio, Gilberto; Paz-Bribiesca, María Minerva; Salcedo-Lozada, Perla; Landa-García, Rodolfo Ángel; Ramírez-Colorado, Rosario; Hernández-Mora, Luis; Pérez-Saldivar, María Luisa; Santamaría-Ascencio, Marlene; López-Loyola, Anselmo; Godoy-Esquivel, Arturo Hermilo; García-López, Luis Ramiro; Anguiano-Ávalos, Alison Ireri; Mora-Rico, Karina; Castañeda-Echevarría, Alejandro; Rodríguez‐Jiménez, Roberto; Cibrian-Cruz, José Alberto; Cárdenas-Cardós, Rocío; Altamirano-García, Martha Beatriz; Sánchez-Ruiz, Martín; Rivera-Luna, Roberto; Rodríguez-Villalobos, Luis Rodolfo; Hernández-Pérez, Francisco; Olvera-Durán, Jaime Ángel; García‐Cortés, Luis Rey; Mata-Rocha, Minerva; Sepúlveda-Robles, Omar Alejandro; Bekker-Méndez, Carolina; Jiménez-Morales, Silvia; Rosas-Vargas, Haydeé; Mejı́a-Aranguré, Juan Manuel

doi:10.1016/j.canep.2020.101731

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…ALL emerges by an abnormal proliferation of immature lymphocytes and their progenitors that replace the hematopoietic elements in the bone marrow and other lymphoid organs. So far, most of the causes of ALL are undeciphered; however, it is well known that an interaction within environmental and genetic factors is needed to develop this malignancy (4)(5)(6). Among the identified risk genetic factors to suffer ALL are the single nucleotide polymorphisms (SNP), both, in coding and no coding genes (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia

et al. 2021

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BackgroundAcute lymphoblastic leukemia (ALL) is characterized by an abnormal proliferation of immature lymphocytes, in whose development involves both environmental and genetic factors. It is well known that single nucleotide polymorphisms (SNPs) in coding and noncoding genes contribute to the susceptibility to ALL. This study aims to determine whether SNPs in miR-146a, miR-196a-2, miR-499a, and miR-612 genes are associated with the risk to ALL in pediatric Mexican population.MethodsA multicenter case-control study was carried out including patients with de novo diagnosis of ALL and healthy subjects as control group. The DNA samples were obtained from saliva and peripheral blood, and the genotyping of rs2910164, rs12803915, rs11614913, and rs3746444 was performed using the 5′exonuclease technique. Gene-gene interaction was evaluated by the multifactor dimensionality reduction (MDR) software.ResultsmiR-499a rs3746444 showed significant differences among cases and controls. The rs3746444G allele was found as a risk factor to ALL (OR, 1.6 [95% CI, 1.05–2.5]; p = 0.028). The homozygous GG genotype of rs3746444 confers higher risk to ALL than the AA genotype (OR, 5.3 [95% CI, 1.23–23.4]; p = 0.01). Moreover, GG genotype highly increases the risk to ALL in male group (OR, 17.6 [95% CI, 1.04–298.9]; p = 0.00393). In addition, an association in a gender-dependent manner among SNPs located in miR-146a and miR-196a-2 genes and ALL susceptibility was found.ConclusionOur findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children. Experimental analysis to decipher the role of these SNPs in human hematopoiesis could improve our understanding of the molecular mechanism underlying the development of ALL.

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Section: Introductionmentioning

confidence: 99%

Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia

et al. 2021

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“…Several research studies have highlighted the potential associations between the exposure to environmental factors and the development of leukemia in the pediatric population of GMC. These factors include the exposure to extremely-low-frequency magnetic fields (ELF-MFs) (Juan C. 15 , 16 ), the maternal and paternal ages at conception of the index child ( 17 ), a greater child´s birthweight ( 18 ), viral infections ( 19 ), father’s occupational exposure ( 20 , 21 ), allergies ( 22 ), breastfeeding (J 23 ), and early-life infections ( 23 ). Additionally, the relationship between genetic and environment interactions has been explored.…”

Section: Introductionmentioning

confidence: 99%

Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

Duarte-Rodríguez,

Flores-Lujano,

McNally

et al. 2024

Front. Oncol.

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BackgroundA heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).MethodsA population-based case-control study was conducted. Children <18 years old, newly diagnosed with ALL and residents of GMC were included. Controls were patients without leukemia recruited from second-level public hospitals, frequency-matched by sex, age, and health institution with the cases. The residence address where the patients lived during the last year before diagnosis (cases) or the interview (controls) was used for geolocation. Kulldorff’s spatial scan statistic was used to detect spatial clusters (SCs). Relative risks (RR), associated p-value and number of cases included for each cluster were obtained.ResultsA total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (p<0.0001) was observed for the main cluster. Similar results were noted for the remaining seven ones. Additionally, a proximity between SCs, electrical installations and petrochemical facilities was observed.ConclusionsThe identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL.

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Maternal and paternal ages at conception of index child and risk of childhood acute leukaemia: A multicentre case-control study in Greater Mexico City

Cited by 3 publications

References 29 publications

Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia

Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia

Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

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