Maternal and neonatal outcomes of pregnancies complicated by late fetal growth restriction undergoing induction of labor with dinoprostone compared with cervical balloon: A retrospective, international study

Mascio, Daniele Di; Villalaín, Cecilia; Rizzo, Giuseppe; Morales‐Roselló, José; Sileo, Filomena Giulia; Maruotti, Giuseppe Maria; Prefumo, Federico; Galindo, Alberto; D’Antonio, F.

doi:10.1111/aogs.14135

Cited by 15 publications

(12 citation statements)

References 28 publications

(58 reference statements)

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“…11 These findings further support the Accepted Manuscript efficacy and safety of prostaglandins in the induction for patients with oligohydramnios 9,11 and fetal growth restriction. 13,14 Conversely, contrary to a recent metanalysis, 13 our study did not demonstrate an increased rate of CD for abnormal fetal heart rate tracing in pregnancies complicated by oligohydramnios with and without FGR. This difference may be because our results are derived from a secondary analysis of a parent database comprised purely of high-risk pregnant women.…”

Section: Results In Context Of What Is Knowncontrasting

confidence: 99%

“…Previous studies have revealed contradictory findings in regard to neonatal adverse events in patients with fetal oligohydramnios and those with FGR. Di Mascio et al in 2021 showed a significant increase in the composite of adverse neonatal outcomes with the use of PGE 2 (26.1%) as compared to mechanical methods (16.7%) in patients with FGR (p=0.013) 14 .…”

Section: Results In Context Of What Is Knownmentioning

confidence: 99%

“…Research on induction of labor methods for patients with FGR has yielded similarly mixed results. Some studies report elevated rates of CD for non-reassuring fetal heart tracing (recurrent decelerations or bradycardia) among those receiving cervical ripening with prostaglandins [13][14][15][16][17] . Other prior reports show either no difference in CD rate 18 or a decreased need for CD 19 in patients whose fetuses have FGR and are induced with prostaglandins.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Delivery Mode among Patients with Oligohydramnios with or without Fetal Growth Restriction by Induction Method

et al. 2022

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Objective: To evaluate the association of induction method on delivery mode in pregnancies complicated by oligohydramnios with and without fetal growth restriction (FGR). Methods: This was a secondary analysis of a National Institutes of Health funded retrospective cohort study of singleton deliveries at a tertiary-care hospital between 2002 to 2013 with diabetes, mild hypertension, and/or FGR. Chart abstraction was performed by trained research nurses. Patients with a diagnosis of fetal oligohydramnios with and without FGR were identified. Our analytic cohort was further stratified into three groups per initial induction agent: prostaglandins alone, prostaglandin plus mechanical ripening, or oxytocin only. Primary outcome was mode of delivery. Secondary outcomes included indications for cesarean delivery and neonatal morbidity. Results: Out of 4,929 patients in the original database, 546 subjects with fetal oligohydramnios were identified; of these 270 were induced and included for analysis. Outcomes were compared between 171 patients who had fetuses with isolated oligohydramnios and 99 patients who had fetuses with oligohydramnios and FGR. There were no significant differences in demographic characteristics between groups. Patients with fetuses with isolated oligohydramnios had similar rates of spontaneous vaginal delivery (SVD) when prostaglandins were used (n=44/79, 55.7% prostaglandin alone, n=44/76, 57.9% prostaglandin with mechanical ripening) and when they were not used (n=5/13, 38.5% oxytocin alone) (p=0.43). Similarly, the majority of patients in both cohorts underwent SVD regardless of induction method (n=30/44, 68.2% prostaglandin alone, n=30/44, 68.2% prostaglandin with mechanical ripening, and n=6/10, 60% oxytocin alone) (p=0.90). There was no significant difference in composite neonatal morbidity. Conclusion: In patients with fetuses with oligohydramnios with and without FGR, most patients delivered by SVD regardless of induction method. In this population, prostaglandin use was associated with a high chance of SVD in patients with fetuses with suspected placental insufficiency regardless of the presence of absence of FGR.

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Section: Results In Context Of What Is Knowncontrasting

confidence: 99%

Section: Results In Context Of What Is Knownmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

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Delivery Mode among Patients with Oligohydramnios with or without Fetal Growth Restriction by Induction Method

et al. 2022

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“…В метаанализе, проведенном группой итальянских и германских исследователей и включавшем 1 711 наблю дений индукции родов при ЗРП и маловесном плоде (вла галищная вставка с динопростоном -571, мизопростол -693, баллонный катетер -341), было показано, что часто та кесарева сечения, проведенного в связи с не обнадеживающим статусом плода по данным КТГ, была в 2 раза выше при динопростоне [46]. Сходные результа ты были получены в многоцентровом исследовании, про-веденном в 6 центрах Италии и Испании и включавшем 571 наблюдение с поздней ЗРП [47]. Таким образом, обзор данных литературы свидетельствует об эффектив ности и безопасности влагалищной системы с динопростоном для подготовки шейки матки и родовозбуждения.…”

Section: Introductionunclassified

The use of a vaginal therapeutic system with prostaglandin for induction of labor

et al. 2022

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Introduction. Induction of labor is one of the most frequent procedures in modern obstetrics, which reduces the frequency of cesarean section and improves pregnancy outcomes. However, the effectiveness and safety of labor induction methods vary. Currently, the vaginal therapeutic system (SVT) with dinoprostone is certified for use for childbirth in Russia. Aim. To conduct a review of the literature data and a pilot study of the effectiveness and safety of the vaginal therapeutic system with dinoprostone for induction of labor. Materials and methods. A review of the literature for 2001–2022 devoted to the use of vaginal systems with gradual release of prostaglandin for induction of labor was conducted. Additionally, a prospective observational study of the effectiveness and safety of the dinoprostone system was conducted in 18 pregnant women. The evaluation criteria were: the frequency of labor, the degree of maturation of the cervix on the Bishop scale, as well as the frequency of vaginal delivery. Results. Literature data indicate that SVT with dinoprostone has comparable efficacy with other methods of pre-induction / induction of labor. The system with dinoprostone has a lower frequency of the side effect of “tachysystole” than the system with misoprostol. Compared with mechanical methods, SVT is assotiated with a lower frequency of oxytocin use. The use of SVT with dinoprostone showed an efficiency of 77.8% (in terms of the of labor start or cervical ripening). No side effects requiring termination of labor induction were registered in our study. Conclusions. Thus, vaginal insertion with prostaglandin E2 – dinoprostone is an effective and safe method of pre-induction of labor. Taking into account the small sample size in our work, it is of interest to continue research in order to obtain more complete data and in comparison with other methods.

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“…Intravenous oxytocin infusion and amniotomy are recommended when the cervix is favorable, otherwise cervical ripening is necessary to increase the likelihood of successful induction [16]. Several methods of cervical ripening are commonly used because the data currently available do not justify to recommend one method over any other [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Methods of induction of labor and women’s experience: a population-based cohort study with mediation analyses

Blanc-Petitjean

Dupont

Carbonne

et al. 2021

BMC Pregnancy Childbirth

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Background Negative childbirth experience may affect mother wellbeing and health. However, it is rarely evaluated in studies comparing methods of induction of labor (IoL). Aim To compare women’s experience of IoL according to the method, considering the mediating role of interventions and complications of delivery. Methods We used data from the MEDIP prospective population-based cohort, including all women with IoL during one month in seven French perinatal networks. The experience of IoL, assessed at 2 months postpartum, was first compared between cervical ripening and oxytocin, and secondarily between different cervical ripening methods. Mediation analyses were used to measure the direct and indirect effects of cervical ripening on maternal experience, through delivery with interventions or complications. Findings The response rate was 47.8% (n = 1453/3042). Compared with oxytocin (n = 541), cervical ripening (n = 910) was associated less often with feelings that labor went ‘as expected’ (adjusted risk ratio for the direct effect 0.78, 95%CI [0.70–0.88]), length of labor was ‘acceptable’ (0.76[0.71–0.82]), ‘vaginal discomfort’ was absent (0.77[0.69–0.85]) and with lower global satisfaction (0.90[0.84–0.96]). Interventions and complications mediated between 6 and 35% of the total effect of cervical ripening on maternal experience. Compared to the dinoprostone insert, maternal experience was not significantly different with the other prostaglandins. The balloon catheter was associated with less pain. Discussion Cervical ripening was associated with a less positive experience of childbirth, whatever the method, only partly explained by interventions and complications of delivery. Conclusion Counselling and support of women requiring cervical ripening might be enhanced to improve the experience of IoL.

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Maternal and neonatal outcomes of pregnancies complicated by late fetal growth restriction undergoing induction of labor with dinoprostone compared with cervical balloon: A retrospective, international study

Cited by 15 publications

References 28 publications

Delivery Mode among Patients with Oligohydramnios with or without Fetal Growth Restriction by Induction Method

Delivery Mode among Patients with Oligohydramnios with or without Fetal Growth Restriction by Induction Method

The use of a vaginal therapeutic system with prostaglandin for induction of labor

Methods of induction of labor and women’s experience: a population-based cohort study with mediation analyses

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