Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: A cross-sectional study

Firoozabadi, Akramsadat Dehghani; Firouzabadi, Razieh Dehghani; Eftekhar, Maryam; Bafghi, Afsar Sadat Tabatabaei; Shamsi, Farimah

doi:10.18502/ijrm.v13i5.7154

Cited by 9 publications

(9 citation statements)

References 17 publications

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“…Polycystic ovary syndrome (PCOS) is a common endocrinopathy with complex pathophysiology that can result in anovulatory infertility in women ( Tanbo et al, 2018 ; Khan et al, 2019 ; Dehghani Firoozabadi et al, 2020 ). In addition to infertility, PCOS can give rise to hyperandrogenism, oligomenorrhea, hyperinsulinemia, chronic anovulation, and an increased risk of metabolic disorders such as type 2 diabetes and cardiovascular disease ( Louwers and Laven, 2020 ; Osibogun et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Sun

Tian

Xue

et al. 2021

Front. Cell Dev. Biol.

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Polycystic ovary syndrome (PCOS) is an endocrinopathy with complex pathophysiology that is a common cause of anovulatory infertility in women. Although the disruption of circadian rhythms is indicated in PCOS, the role of the clock in the etiology of these pathologies has yet to be appreciated. The nuclear receptors REV-ERBα and REV-ERBβ are core modulators of the circadian clock and participate in the regulation of a diverse set of biological functions. However, in PCOS, the expression of REV-ERBs and their effects remain unclear. Here, we demonstrate that the levels of REV-ERBα and REV-ERBβ expression were lower in the granulosa cells of PCOS patients than in control subjects. In vitro, we found that the overexpression of REV-ERBα and REV-ERBβ, and their agonist SR9009, promoted the expression of mitochondrial biosynthesis genes PGC-1α, NRF1, and TFAM and inhibited autophagy in KGN cells. Our results also indicate that REV-ERBα and REV-ERBβ can inhibit apoptosis in granulosa cells and promote proliferation. Importantly, the REV-ERB agonist SR9009 ameliorates abnormal follicular development by promoting mitochondrial biosynthesis and inhibiting autophagy in a mouse PCOS model. This allows us to speculate that SR9009 has potential as a therapeutic agent for the treatment of PCOS.

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Section: Introductionmentioning

confidence: 99%

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Sun

Tian

Xue

et al. 2021

Front. Cell Dev. Biol.

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“…ICU admissions differed among the three PCOS groups; however, after correction, this was not statistically significant [ 44 ]. Among the four phenotypes of PCOS studied, no statistically significant differences were found in the incidence of neonatal birth weight, neonatal icterus, NICU admission, or neonatal death [ 45 ]. While a good amount of studies found additional risks, several studies found no difference in Apgar, birth weight, and incidence of hypoglycemia, which was also seen in comparing fertilization methods [ 37 , 39 , 43 , 44 , 46 ].…”

Section: Reviewmentioning

confidence: 99%

“…PCOS consists of four phenotypes A-D, but in general, it has been observed that pregnant women with PCOS consisting of hyperandrogenism and oligomenorrhea, such as A and B, were at an increased risk of developing GDM [ 47 , 48 ]. Conclusions of which phenotype was more likely to develop GDM were split, with some studies observing that phenotype A was associated with the highest incidence of GDM with up to 27.5% of patients [ 26 , 28 , 44 , 45 , 53 , 57 ]. In contrast, other studies found no significant difference [ 26 , 28 , 44 , 45 , 53 , 57 ].…”

Section: Reviewmentioning

confidence: 99%

“…Conclusions of which phenotype was more likely to develop GDM were split, with some studies observing that phenotype A was associated with the highest incidence of GDM with up to 27.5% of patients [ 26 , 28 , 44 , 45 , 53 , 57 ]. In contrast, other studies found no significant difference [ 26 , 28 , 44 , 45 , 53 , 57 ]. One study, however, determined that phenotype D was associated with the lowest incidence of GDM [ 45 ].…”

Section: Reviewmentioning

confidence: 99%

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Gestational Diabetes Mellitus in the Setting of Polycystic Ovarian Syndrome: A Systematic Review

Slouha,

Alvarez,

Gates

et al. 2023

Cureus

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Gestational diabetes mellitus (GDM) is the most common complication of pregnancy that arises in the 2nd and 3rd trimesters, leading to significant complications for the mother and her neonates, such as an increased rate of pregnancy-induced hypertension and miscarriages, while neonates may have a large birth weight, hypoglycemia, or macrosomnia. Numerous risk factors can lead to GDM; however, a significant one is polycystic ovarian syndrome (PCOS). PCOS is the most common endocrine pathology beginning before puberty, and due to significant hormonal changes, it is not diagnosed until after puberty. PCOS requires at least three of the following symptoms: hyperandrogenism, menstrual irregularities, or polycystic ovary morphology. While it is agreed that women with PCOS are at a significantly increased risk of GDM, no publication to our knowledge has evaluated the full relationship of GDM in the setting of PCOS. This paper aimed to assess this relationship and determine how it may differ for pregnant women with only GDM by determining the prevalence of GDM, the variations within phenotypes, the influence of fertilization methods, specific risk factors, maternal outcomes, and neonatal outcomes. The prevalence of GDM was significantly increased in women with PCOS compared to healthy controls, and some studies have found that phenotype A may be more likely to lead to GDM. Risk factors were similar to pregnant women with only GDM, but with GDM and PCOS specifically, preconception low sex hormone-binding globulin, increased BMI > 25 kg/m2, and preconception impaired glucose tolerance were specific. While maternal outcomes were similar to pregnant women with only GDM, women with GDM and PCOS were even more likely to develop pregnancy-induced hypertension and early miscarriage. Neonates from mothers with GDM and PCOS were more likely to have low birth weights compared to mothers with just GDM who had high birth weights. The evaluation of the relationship between GDM and PCOS allows for illumination of the need to evaluate influences that currently lack research, such as phenotype variation and influences of fertilization method. This also promotes the need to develop predictive algorithms based on risk factors to prevent these adverse outcomes for mothers and neonates.

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“…Epidemiological data recommend that PCOS causes a high prevalence of ovarian dysfunction and anovulation, where both of these conditions are positively correlated with a progressive chance of infertility [ 12 ]. Women with polycystic ovary syndrome appear to experience various conditions during pregnancy, including abortion, preterm delivery, and intrauterine death or stillbirth [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on CYP11A1, CYP17A1, and CYP19A1 Polymorphism Studies: Candidate Susceptibility Genes for Polycystic Ovary Syndrome (PCOS) and Infertility

Heidarzadehpilehrood

Pirhoushiaran

Abdollahzadeh

et al. 2022

Genes

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Polycystic ovary syndrome is a multifactorial condition associated with reproductive and endocrine organs and might cause infertility and metabolic abnormalities in childbearing age. PCOS seems to be a multifactorial disorder resulting from the combination of several genetic and environmental factors. Little research has been conducted to date on the impact of polymorphisms in infertility. We aim to review the appearance of polymorphisms in females of diverse ethnicities and their effect on infertility in the population with polycystic ovary syndrome. There have been numerous reports of the importance of the steroidogenesis pathway and genetic variants in PCOS pathogenesis. The most important genes that play a role in the aetiology of PCOS are CYP11A1, CYP17A1, and CYP19A1. We evaluated the occurrence of polymorphisms in various ethnicities in the CYP11A1, CYP17A1, and CYP19A1 genes and their efficacy on increasing PCOS risk with infertility. Our findings revealed that polymorphisms in various ethnicities are associated with the risk of PCOS with infertility. Although conflicting results regarding CYP11A1, CYP17A1, and CYP19A1 polymorphisms and their influence on PCOS with infertility have been reported in a small number of papers, the authors feel this may be attributable to the sample size and ethnic composition of the examined populations. In conclusion, our study strongly suggests that the CYP11A1, CYP17A1, and CYP19A1 genes might significantly enhance the probability of developing PCOS with infertility.

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Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: A cross-sectional study

Cited by 9 publications

References 17 publications

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Gestational Diabetes Mellitus in the Setting of Polycystic Ovarian Syndrome: A Systematic Review

A Review on CYP11A1, CYP17A1, and CYP19A1 Polymorphism Studies: Candidate Susceptibility Genes for Polycystic Ovary Syndrome (PCOS) and Infertility

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