Maternal and infant characteristics by mode of vitamin K prophylaxis administration

Khambalia, Amina; Roberts, Christine L.; Bowen, Jennifer R.; Nassar, Natasha

doi:10.1111/j.1440-1754.2012.02448.x

Cited by 16 publications

(25 citation statements)

References 7 publications

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“…Our study showed that mothers who refused vitamin K prophylaxis were more likely to choose a planned birth at home or at a birth center and an epidural-free vaginal delivery. This finding is consistent with the study by Khambalia et al 10 It is possible that some parents decline vitamin K prophylaxis because of safety concerns. In the 1990s, 2 studies by Golding et al 11,12 suggested an increased likelihood of childhood cancer with vitamin K intramuscular injection.…”

Section: Discussionsupporting

confidence: 83%

Neonatal Vitamin K Refusal and Nonimmunization

2014

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BACKGROUND: Neonatal Vitamin K prophylaxis is an effective intervention for reducing vitamin K deficiency bleeding. A recently published report of parental refusal of vitamin K prompted an investigation of the prevalence and characteristics of this group, and exploration of whether these same parents were likely to subsequently refuse immunization for their children. METHODS: We conducted a retrospective population-based cohort study of all infants born in Alberta between 2006 and 2012 by using linkage of administrative health data. Risk factors for vitamin K refusal were determined by using Poisson regression. The association between vitamin K refusal and nonimmunization was assessed using relative risk. RESULTS: Among the 282 378 children in the cohort, 99.7% received vitamin K and 0.3% declined. Midwife-assisted deliveries were more likely to be associated with vitamin K refusal compared with physician-attended delivery (risk ratio 8.4, 95% confidence interval [CI] 6.5–11.0). Planned home delivery (risk ratio 4.9, CI 3.8–6.4) or delivery in a birth center (risk ratio 3.6, CI 2.3–5.6) were more likely to result in decline of vitamin K compared with hospital delivery. Vitamin K refusal was associated with a 14.6 (CI 13.9–15.3) higher relative risk of having no recommended childhood vaccines at 15 months. CONCLUSIONS: This is the first population-based study to characterize parents who are likely to decline vitamin K for their infants and whose children are likely to be unimmunized. These findings enable earlier identification of high-risk parents and provide an opportunity to enact strategies to increase uptake of vitamin K and childhood immunizations.

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Section: Discussionsupporting

confidence: 83%

Neonatal Vitamin K Refusal and Nonimmunization

2014

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“…Vaginal birth (also seen in recent Australian data) 15 and higher gestational age were negatively associated with IM uptake. In these instances, as previously suggested, 15 opting for no or oral vitamin K, appears aligned with parental and professional attitudes and preferences for natural birth. In addition, this may reflect a false perception that babies born by normal birth are less susceptible to VKDB.…”

Section: Design and Data Sourcesmentioning

confidence: 76%

“…In our cohort, we have shown IM uptake at 92.9%, lower than all available past data for comparison -NZ and Australian at 96 and 96.3%, respectively, 3,15 and Canadian at 99.3%. 14 The main reason for this difference between countries is perhaps seen in the more than two-fold increase in oral vitamin K in our cohort.…”

Section: Design and Data Sourcesmentioning

confidence: 96%

Perinatal influences on the uptake of newborn Vitamin K prophylaxis – a retrospective cohort study

Burke

Bernhardt

Reith

et al. 2015

Australian and New Zealand Journal of Public Health

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“…One common intramuscular injection for neonates is a vitamin K formulation for prophylaxis against vitamin K deficiency bleeding [71,72]. In this case, the intramuscular injection is preferred and used because of superior efficacy to the oral formulation [71,72]. Vaccines are also largely administered by this route [70]; however, this intramuscular injection can cause pain and sterile abscesses in the neonate.…”

Section: Intramuscularmentioning

confidence: 99%

“…When intramuscular injections are used, the target injection site is typically the anterolateral thigh [70]. One common intramuscular injection for neonates is a vitamin K formulation for prophylaxis against vitamin K deficiency bleeding [71,72]. In this case, the intramuscular injection is preferred and used because of superior efficacy to the oral formulation [71,72].…”

Section: Intramuscularmentioning

confidence: 99%

Challenges Associated with Route of Administration in Neonatal Drug Delivery

et al. 2015

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The administration of drugs to neonates poses significant challenges. The aim of this review was to provide insight into some of these challenges and resolutions that may be encountered with several of the most commonly used routes of administration and dosage forms in neonatal care, including oral, parenteral, transdermal, intrapulmonary, and rectal. Important considerations include fluctuations in stomach pH hours to years after birth, the logistics of setting up an intravenous infusion, the need for reduced particle size for aerosol delivery to the developing neonatal lung, and variation in perirectal venous drainage. Additionally, some of the recently developed technologies for use in neonatal care are described. While the understanding of neonatal drug delivery has advanced over the past several decades, there is still a deficiency of technologies and formulations developed specifically for this population.

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Maternal and infant characteristics by mode of vitamin K prophylaxis administration

Cited by 16 publications

References 7 publications

Neonatal Vitamin K Refusal and Nonimmunization

Neonatal Vitamin K Refusal and Nonimmunization

Perinatal influences on the uptake of newborn Vitamin K prophylaxis – a retrospective cohort study

Challenges Associated with Route of Administration in Neonatal Drug Delivery

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