Maternal and fetal prolactin in pregnancy-induced hypertension

Marlettini, M. G.; Cassani, A.; Morselli-Labate, Antonio Maria; Crippa, Stefania; Contarini, A.; Miniero, R.; Platé, L.; Orlandi, C

doi:10.1007/bf02390664

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…A higher rate of preterm delivery (28% versus 9% in the control group) (p=0.0003) was ascribed to maternal disease for which the drugs were prescribed. In two therapeutic trials of verapamil among hypertensive pregnant women, no adverse drug-related effects were observed among infants (79).…”

Section: Calcium Channel Blockersmentioning

confidence: 95%

Management of Bipolar Disorder During Pregnancy and the Postpartum Period

Yonkers

Wisner

Stowe³

et al. 2004

AJP

336

199

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Since treatment can be managed most effectively if pregnancy is planned, clinicians should discuss the issue of pregnancy and its management with every bipolar disorder patient who has childbearing potential, regardless of future reproductive plans. Additional research should address the risks of disturbed sleep to pregnant and postpartum women with bipolar disorder, as well as structural and behavioral consequences to offspring when mood stabilizers are used during pregnancy. Longitudinal and cohort studies can promote these efforts. Given the rate of bipolar disorder in the general population, research efforts will need to be broad based and include multiple collaborating centers.

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Section: Calcium Channel Blockersmentioning

confidence: 95%

Management of Bipolar Disorder During Pregnancy and the Postpartum Period

Yonkers

Wisner

Stowe³

et al. 2004

AJP

336

199

View full text Add to dashboard Cite

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“…A study by Marlettini MG et al, also havereported higher plasma prolactin levels in women with pregnancy induced hypertension (PIH) at 39 weeks of gestation when compared to controls. 7 Similarly, Hayashi RH et al have reported the significant elevation of prolactin in PIH group in comparison to normal pregnancy only at the 37 to 39 gestational weeks interval but the difference did not reach the significant level when the overall value of 16-42 gestational weeks was compared. Pre-eclampsia is a placenta dependent disease exemplified by the fact that all the symptoms disappear after delivery.…”

Section: Discussionmentioning

confidence: 93%

“…12 Notably, these vasoinhibins have been associated with the endothelial cell dysfunction and compromised birth weight that characterize preeclampsia Though it has been proposed that prolactin causes rise in MAP based on rabbit studies, 13 the same might not hold true for humans as evidenced by poor correlation between MAP and serum prolactin in our study.This is in agreement with one of the studies that have shown a non-significant relationship between the blood pressure and the prolactin levels. 7 In this regard, serum prolactin is not a good indicator of severity of disease, based on its poor correlation with MAP and 24h UTP, which are established markers of the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Can serum prolactin be a reliable marker for preeclampsia? A hospital based study on Nepalese mothers

Timalsina

Gyawali

2015

J Chitwan Med Coll

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Preeclampsia is a pregnancy specific complication characterized by hypertension, proteinuria and oedema. It has remained as a major cause of maternal and perinatal morbidity and mortality worldwide. The major function of prolactin is its role in lactation during pregnancy, but many authors have claimed that this hormone is also involved in angiogenesis, thus linking it with the pathogenesis of preeclampsia. In this context, our study aims to compare the serum prolactin level between preeclamptic and healthy pregnancies and correlate with the severity.A total of 54 pregnant women diagnosed with preeclampsia and 60 age and gestational weeks matched healthy pregnant women were recruited in this case control study. Preeclampsia was defined as per Australasian Society Consensus Statement research definition. Among 54 preeclamptic women, 41 had mild preeclampsia and 13 had severe preeclampsia. The mean age and the gestational weeks of the preeclamptic cases and pregnant controls were not significantly different. This study showed that the median concentration of prolactin was significantly higher in preeclampsia than in normal pregnancies (156.6 vs. 129.8 ng/mL, P=0.012). Though the median concentration of prolactin was higher in severe preeclampsia in comparison to mild one, the difference did not reach the significant level (228.3 vs.152.9 ng/mL, P=0.061). No significant correlation of prolactin was found with mean arterial pressure and 24h UTP. Due to poor correlation with established markers of severity, serum prolactin is not a reliable marker of preeclampsia.

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“…Maternal and cord blood prolactin level have been linked to pregnancy complications such as gestational diabetes, pregnancy induced hypertension, prematurity and respiratory distress syndrome 6,8-11. Most studies have concentrated on the role of cord blood prolactin in lung maturity.…”

Section: Introductionmentioning

confidence: 99%

Maternal and cord blood prolactin level and pregnancy complications

Alawad

Al-Omary

2019

Pak J Med Sci

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Objectives: To explore the correlation between maternal and cord blood prolactin, the correlation between cord prolactin and birth weight, and to compare cord blood prolactin in new-borns of women with normal pregnancy and women with pregnancy complications namely; gestational hypertension, gestational diabetes and preterm labour.Methods: This study was performed from September to December 2018. Thirty-two women, delivered at Baghdad teaching hospital, and their newborns (32) were included. Maternal blood (5 ml) was taken before labour and cord blood (5 ml) was collected after placenta expulsion. Maternal and cord blood prolactin were analysed using fluorescence immunoassay. Results: Cord blood prolactin was higher in babies born to hypertensive women (405.28±77.52 ng/ml) than normal pregnancy women (244.80±60.80 ng/ml), P=0.000. Also, cord prolactin in gestational hypertension group was significantly higher than diabetic (P=0.006) and preterm labour (P=0.000) groups. No significant difference was noticed in cord blood prolactin in newborns of diabetic and normal pregnancy women (299.28±37.01, 244.80±60.80 ng/ml respectively, P=0.053). Preterm babies had lower cord prolactin (204.57±22.90 ng/ml) than normal pregnancy babies (244.80±60.80 ng/ml), however the difference was non-significant, P=0.118. Positive correlation was found between cord and maternal prolactin (P=0.000) and between cord prolactin and birth weight (P=0.018). Conclusion: Cord blood prolactin is high in newborns of hypertensive women, low in preterm neonates. Diabetes has no effect on cord prolactin level. doi: https://doi.org/10.12669/pjms.35.4.558 How to cite this:Alawad ZM, Al-Omary HL. Maternal and cord blood prolactin level and pregnancy complications. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.558 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Maternal and fetal prolactin in pregnancy-induced hypertension

Cited by 8 publications

References 18 publications

Management of Bipolar Disorder During Pregnancy and the Postpartum Period

Management of Bipolar Disorder During Pregnancy and the Postpartum Period

Can serum prolactin be a reliable marker for preeclampsia? A hospital based study on Nepalese mothers

Maternal and cord blood prolactin level and pregnancy complications

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