Maternal and fetal outcome among pregnant women presenting with thrombocytopenia

Chauhan, Vikrant; Gupta, Amit; Mahajan, Neelam; Vij, Anju; Kumar, R.; Chadda, Abhinav

doi:10.18203/2320-1770.ijrcog20162658

Cited by 10 publications

(29 citation statements)

References 14 publications

(28 reference statements)

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“…In the present study moderate thrombocytopenia was found in 39.42% women. This was similar to studies conducted by Chauhan et al [11] and Zutshi et al [16] (35.4% and 31% respectively) where in the studies conducted by Singh et al [17] and Vishwekar et al, [18] the incidence of moderate thrombocytopenia was lower as compared to our study (17.9% and 15.2% respectively). In the present study, severe thrombocytopenia was seen in 6.73% of pregnant women which is almost similar to the study conducted by Singh et al [17] (7.4%), Vishwekar et al [18] (6.4%) and Zutshi et al [16] (7%).…”

Section: Discussionsupporting

confidence: 92%

“…Jaleel et al [15] found mean platelet count to be 203400±25040.00/µl which is comparable to our study. Mean platelet count in our study in pregnant women with thrombocytopenia was 98028.84±25679.67/µl which is almost similar to study conducted by Chauhan et al [11] where it was 106907.7±30136.52/µl. In our study, majority of women (53.85%) had mild thrombocytopenia, though this incidence is slightly lower than other studies reported by Zutshi et al [16] and Singh et al [17] and Chauhan et al [11] (62%, 74.3% and 63%, respectively).…”

Section: Discussionsupporting

confidence: 89%

“…However, incidence was low (4.30%) in the study conducted by Lin et al [9] as they excluded women with major systemic diseases as well as those with gestational hypertension. Slightly higher incidence (13.5%) was noted in study by Ajibola et al [10] Mean age of women with thrombocytopenia was 23.89±3.31 years and in pregnant women without thrombocytopenia it was 24.34±3.79 years with being comparable (p >0.05) and is similar to study conducted by Chauhan et al [11] i.e. 25.74±3.86 years.…”

Section: Discussionsupporting

confidence: 82%

“…In the present study, severe thrombocytopenia was seen in 6.73% of pregnant women which is almost similar to the study conducted by Singh et al [17] (7.4%), Vishwekar et al [18] (6.4%) and Zutshi et al [16] (7%). Severe thrombocytopenia was seen in higher percentage of pregnant women (20%) in the study by Pandey et al [19] However, Chauhan et al [11] observed a very low (1.5%) incidence of severe thrombocytopenia the reason of which was not explained by them. [17] 74.7% 17.9% 7.4% Vishwekar et al [18] 78.4% 15.2% 6.4% Chauhan et al [11] 63.1% 35.4% 1.5% Zutshi et al [16] 62% 31% 7% Pandey et al [19] 22% In our study, gestational thrombocytopenia (69.23%) was the commonest etiology which was similar to the study conducted by Vishwekar et al [18] (68.46%) and Chauhan et al [11] (68.2%).…”

Section: Discussionmentioning

confidence: 92%

“…Severe thrombocytopenia was seen in higher percentage of pregnant women (20%) in the study by Pandey et al [19] However, Chauhan et al [11] observed a very low (1.5%) incidence of severe thrombocytopenia the reason of which was not explained by them. [17] 74.7% 17.9% 7.4% Vishwekar et al [18] 78.4% 15.2% 6.4% Chauhan et al [11] 63.1% 35.4% 1.5% Zutshi et al [16] 62% 31% 7% Pandey et al [19] 22% In our study, gestational thrombocytopenia (69.23%) was the commonest etiology which was similar to the study conducted by Vishwekar et al [18] (68.46%) and Chauhan et al [11] (68.2%). The incidence of thrombocytopenia in neonates born to gestational thrombocytopenic women is similar to those reported ~ 131 ~ in non gestational thrombocytopenia women [20] .…”

Section: Discussionmentioning

confidence: 92%

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A prospective study to evaluate the role of maternal thrombocytopenia on maternal and fetal outcome

Chauhan¹,

Chaudhary²,

Mehta³

et al. 2021

Int. J. Clin. Obstet. Gynaecol.

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Introduction: Thrombocytopenia is a very common finding in pregnancy, occurring in approximately 10% of women and it is the second most common hematological abnormality during pregnancy. Aims and Objective: To study the cases of thrombocytopenia during pregnancy, its cause and effect on feto-maternal outcome. Material and Methods: Prospective observational study included 1000 women (>30 weeks of gestation) out of which 104 women were found to had thrombocytopenia and 896 women had normal platelet count. Results: Mean age among thrombocytopenic women was 23.89±3.31 years and in without thrombocytopenia, it was 24.34±3.79 years. 39(37.5%) women with thrombocytopenia and 471(52.56%) women without thrombocytopenia were nulliparous, 65(62.5%) women with thrombocytopenia and 425(47.44%) women without thrombocytopenia were multiparous. Mean gestational age was 37.05±2.26 weeks observed in women with thrombocytopenia and in women without thrombocytopenia, it was 37.46±2.35 weeks. Mean platelet counts of pregnant women with thrombocytopenia was 98028.84±25679.67/µL and in pregnant women without thrombocytopenia, it was 243198.66±49245.80/µL. A total of 56(53.85%) women had mild thrombocytopenia, 41(39.42%) had moderate and 7(6.73%) women had severe thrombocytopenia. Most common diagnosis observed was gestational thrombocytopenia i.e. 72(69.23%) cases followed by preeclampsia (16.34%). Vaginal delivery found to be most common i.e. 72(69.23%) followed by 32(30.77%) cases of cesarean delivery. Fetal distress was the most common indication of cesarean section i.e. 18 (17.30%) cases. Mean birth weight was 2.84±0.62kgs. Apgar score of 7/9 observed in 96(92.30%) neonates. Out of 104 babies, 4(3.84%) intrauterine death were occurred and 18(17.30%) babies were premature. Mean hospital stay of the women was 5.01±4.25 days. In mild category, mean hospital stay was 4.75±3.89 days, in moderate it was 5±4.18 days and in severe in severe, it was 6.71±0.677 days (p >0.05). Conclusion:Present study concluded that early interdisciplinary evaluation of thrombocytopenia in pregnancy is required for optimal care of mother and the neonate as risk varies greatly depending on cause of thrombocytopenia. Accurate etiological diagnosis is essential for optimal therapeutic management and timely monitoring of platelet count is mandatory.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 92%

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A prospective study to evaluate the role of maternal thrombocytopenia on maternal and fetal outcome

Chauhan¹,

Chaudhary²,

Mehta³

et al. 2021

Int. J. Clin. Obstet. Gynaecol.

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Thrombocytopenia and associated factors among pregnant women attending antenatal care at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia: A cross-sectional study

Arkew,

Asmerom,

Sileshi

et al. 2024

Medicine

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Thrombocytopenia (TCP) is the second most common hematological change during pregnancy and is considered as a major source of maternal and neonatal morbidity and mortality. Despite its effects to morbidity and mortality, it is frequently ignored or disregarded, particularly in resource-limited nations. Thus, the purpose of this study was to determine the prevalence of thrombocytopenia and associated factors among pregnant women attending antenatal care at Hiwot Fana Comprehensive Specialized University Hospital, Eastern Ethiopia from June 20 to August 30, 2022. A hospital-based cross-sectional study was conducted among 199 pregnant women selected through a systematic sampling technique. Ethical approval was obtained from the Ethics Review Committee of Haramaya University. Data related to sociodemographic and reproductive variables were collected using structured questionnaires. Four milliliters of venous blood were collected from each study participant and a complete blood cell count was determined using UniCel DxH 800 hematology analyzer. Logistic regression analysis was done to assess the association between TCP and independent variables and P < .05 was considered statistically significant. In this study, the prevalence of TCP was 14.1% (95% CI: 9.6–19.7). Of them, 10 (35.7%), 12 (42.9%), and 4 (21.4%) had mild, moderate, and severe TCP, respectively. Having more than 3 children (adjusted odds ratio, AOR = 7.90, 95% CI: 2.60, 24.3), no antenatal care follow-up (AOR = 7.90, 95% CI: 2.40–26.2), being in the second and third trimester (AOR = 6.90, 95% CI: 1.70, 28.9 and AOR = 5.04, 95% CI: 1.12, 22.7, respectively), and history of heavy menstrual bleeding (AOR = 4.03, 95% CI: 1.25, 13.1) were significantly associated with TCP. TCP is a public health problem among pregnant women in the study area. Having more than 3 children, lack of antenatal care follow-up, being in the second and third trimesters, and having history of heavy menstrual bleeding was significantly associated with TCP. As a result, regular platelet count monitoring and appropriate intervention approaches based on identified predictors should be explored to mitigate adverse outcomes in pregnant women.

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The diagnostic accuracy of mean platelet volume in differentiating immune thrombocytopenic purpura from hypo-productive thrombocytopenia: A systematic review and meta-analysis

Walle,

Arkew,

Asmerom

et al. 2023

PLoS ONE

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Background Thrombocytopenia is defined as a decreased number of platelets in the circulating blood as a result of hypo-proliferation in marrow or peripheral destruction of platelets. Several diagnostic methods have been proposed to discriminate the underline cause of thrombocytopenia. Recent studies showed that mean platelet volume (MPV) could be used for differential diagnosis of immune thrombocytopenic purpura (ITP). Thus, we aimed to investigate the diagnostic accuracy of MPV for differential diagnosis of ITP from hypo-productive thrombocytopenia. Methods This study was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines (PRISMA). The study protocol was registered on PROSPERO with the reference number CRD42023447789. Relevant published studies that were published up to April 10, 2023, in peer-reviewed journals were searched on electronic different databases. The methodological quality of the included studies was appraised using the quality assessment of diagnostic accuracy studies 2 (QADAS-2) tool. The pooled weight mean difference (WMD) of MPV between the ITP group and hypo-productive group was analyzed using a random-effects model meta-analysis. Relevant data were extracted using a Microsoft Excel spreadsheet and analyzed using STATA 11.0 and Meta-disc 1.4 software. Publication bias was evaluated using Deek’s funnel plot asymmetry test. Results A total of 14 articles were included in this systematic review and meta-analysis. The comparison of MPV between groups revealed that the pooled mean value of MPV increased significantly in ITP patients compared to patients with hypo-productive thrombocytopenia (WMD = 2.03; 95% CI, 1.38–2.69). The pooled sensitivity and specificity of MPV in differentiating ITP from hypo-productive thrombocytopenia were 76.0% (95% CI: 71.0%, 80.0%) and 79.0% (95% CI: 75.0%, 83.0%), respectively. The summary positive likelihood ratio (PLR) and negative likelihood ratio (NLR)using the random effects model were 3.89 (95% CI: 2.49, 6.10) and 0.29 (95% CI: 0.18, 0.46), respectively. Conclusion MPV can be used to discriminate ITP from hypo-productive thrombocytopenia. It can possess large advantages as it is noninvasive, simple, quick, inexpensive, easy to perform, reliable, and routinely generated by automated cell counters.

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Maternal and fetal outcome among pregnant women presenting with thrombocytopenia

Cited by 10 publications

References 14 publications

A prospective study to evaluate the role of maternal thrombocytopenia on maternal and fetal outcome

A prospective study to evaluate the role of maternal thrombocytopenia on maternal and fetal outcome

Thrombocytopenia and associated factors among pregnant women attending antenatal care at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia: A cross-sectional study

The diagnostic accuracy of mean platelet volume in differentiating immune thrombocytopenic purpura from hypo-productive thrombocytopenia: A systematic review and meta-analysis

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