Maternal and fetal HLA-G 14 bp gene polymorphism in pregnancy-induced hypertension, preeclampsia, intrauterine growth restricted and normal pregnancies

Mandò, Chiara; Pileri, Paolo; Mazzocco, M.; Lattuada, D.; Zolin, A.; Plebani, Maddalena; Massari, Maddalena; Calabrese, Stefania; Milani, Silvano; Cetin, Irene

doi:10.3109/14767058.2015.1052398

Cited by 21 publications

(14 citation statements)

References 29 publications

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“…Many studies have shown that the HLA-G level was associated with complications of pregnancy like recurrent miscarriages and preeclampsia (14,15,29,35,36,37). Our results did not reveal any association between the HLA-G 14 bp polymorphism and the 1597∆C polymorphism tagging the HLA-G*01:05N null allele and the risk of pre-eclampsia in Slovak women.…”

Section: Discussioncontrasting

confidence: 83%

“…The 14 bp insertion polymorphism has been associated with lower levels of soluble HLA-G suggesting its role in PE development (13,27). We did not fi nd any statistically signifi cant differences in HLA-G 14 bp ins/del allele and genotype distribution between women with PE and controls as given by others (19,20,28,29). The newest meta-analysis of several smaller studies also revealed no associations between the HLA-G 14 bp ins/del genotype and development of PE (30).…”

Section: Discussioncontrasting

confidence: 42%

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Analysis of HLA-G gene polymorphisms in Slovak women with pre-eclampsia

Ďurmanová¹,

Drobny²,

Shawkatová³

et al. 2017

BLL

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OBJECTIVES: To identify possible association between the selected HLA-G gene polymorphisms and risk of pre-eclampsia. BACKGROUND: Pre-eclampsia is a serious multisystem disorder that affects women during pregnancy. Despite many research studies, the pathology of pre-eclampsia is not fully understood. Human leukocyte antigen G (HLA-G) belongs to the molecules that induce fetal acceptance by the maternal immune system. HLA-G expression was found to be impaired in the women suffering from pre-eclampsia suggesting its involvement in the development of pre-eclampsia. METHODS: 123 women with pre-eclampsia and 102 women with normotensive pregnancy were included in the study.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussioncontrasting

confidence: 42%

Analysis of HLA-G gene polymorphisms in Slovak women with pre-eclampsia

Ďurmanová¹,

Drobny²,

Shawkatová³

et al. 2017

BLL

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“…However, we did not find any associations (Tables S1-S3). While the HLA-G 14-bp ins/del polymorphism is related to HLA-G expression in in vitro studies, several other polymorphisms may influence the expression levels in vivo (57)(58)(59). In fact, polymorphisms residing in the regulatory regions of the HLA-G gene, 5 ′ URR and 3 ′ UTR, have been shown to be in high linkage disequilibrium with the 14-bp ins/del polymorphism, and believed to affect the rate of transcription and mRNA stability conjointly (32,48).…”

Section: Discussionmentioning

confidence: 99%

Distribution of HLA‐G extended haplotypes and one HLA‐E polymorphism in a large‐scale study of mother–child dyads with and without severe preeclampsia and eclampsia

Nilsson

Djurisic

Andersen

et al. 2016

HLA

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The etiological pathways and pathogenesis of preeclampsia have rendered difficult to disentangle. Accumulating evidence points toward a maladapted maternal immune system, which may involve aberrant placental expression of immunomodulatory human leukocyte antigen (HLA) class Ib molecules during pregnancy. Several studies have shown aberrant or reduced expression of HLA-G in the placenta and in maternal blood in cases of preeclampsia compared with controls. Unlike classical HLA class Ia loci, the nonclassical HLA-G has limited polymorphic variants. Most nucleotide variations are clustered in the 5'-upstream regulatory region (5'URR) and 3'-untranslated regulatory region (3'UTR) of HLA-G and reflect a stringent expressional control. Based on genotyping and full gene sequencing of HLA-G in a large number of cases and controls (n > 900), the present study, which to our knowledge is the largest and most comprehensive performed, investigated the association between the HLA-G 14-bp ins/del (rs66554220) and HLA-E polymorphisms in mother and newborn dyads from pregnancies complicated by severe preeclampsia/eclampsia and from uncomplicated pregnancies. Furthermore, results from extended HLA-G haplotyping in the newborns are presented in order to assess whether a combined contribution of nucleotide variations spanning the 5'URR, coding region, and 3'UTR of HLA-G describes the genetic association with severe preeclampsia more closely. In contrast to earlier findings, the HLA-G 14-bp ins/del polymorphism was not associated with severe preeclampsia. Furthermore, the polymorphism (rs1264457) defining the two nonsynonymous HLA-E alleles, HLA-E*01:01:xx:xx and HLA-E*01:03:xx:xx, were not associated with severe preeclampsia. Finally, no specific HLA-G haplotypes were significantly associated with increased risk of developing severe preeclampsia/eclampsia.

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“…The same genotype (14‐bp ins/ins) was more frequent in women with more than three recurrent spontaneous abortions compared to fertile controls . However, in several studies, no relationship of the 14‐bp ins/ins genotype was reported for pregnancy complications such as preeclampsia, restricted intrauterine growth, recurrent spontaneous abortion, and implantation failure …”

Section: Discussionmentioning

confidence: 97%