Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review

Fried, David A.; Rhyu, Jane; Odato, Karen; Blunt, Heather; Gilbert‐Diamond, Diane

doi:10.1093/nutrit/nuv108

Cited by 15 publications

(12 citation statements)

References 82 publications

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“…Similar results in adults were reported by Jolliffe et al [126]. Some SRs on prenatal vitamin D status (assessed by maternal or cord blood 25(OH)D mainly derived from birth cohort studies) and ARI reported mixed results [71,74,126,128]. In the MA by Pacheco-Gonzalez et al, the pooled odds ratio for ARI in the offspring was 0.64 (95% CI 0.47 to 0.87) when comparing the highest with the lowest 25(OH)D category [74], whereas there was no significant result for such an association in the MA by Feng et al [71].…”

Section: Primary Preventionsupporting

confidence: 82%

“…In our search for SRs on vitamin D and ARI, we identified 14 records [71,74,77,100,[126][127][128][129][130][131][132][133][134][135]; of which five reported data on cohort studies; [71,74,100,126,128] and 11 included MAs from RCTs [77,100,126,127,[129][130][131][132][133][134][135] (Supplemental Tables S10-S13 and Figure S3). Using AMSTAR 2 as an instrument for assessing methodological quality, 8 of the 14 SRs that examined the association between vitamin D and the prevention or treatment of ARI can be categorised as high quality; three studies were categorised as medium quality; and the other two studies as low and very low quality, whereas AMSTAR 2 was not developed to assess the quality of the only IPD MA.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the association of vitamin D status and risk of ARI, we identified five SRs of cohort studies with very heterogeneous study quality according to AMSTAR 2 assessment [71,74,100,126,128]. In adults, Autier et al found two studies reporting on an inverse association between serum 25(OH)D and respiratory infections and one study showing an inverse association between serum 25(OH)D and days of absence due to respiratory infections [100].…”

Section: Primary Preventionmentioning

confidence: 99%

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Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Maretzke¹,

Bechthold²,

Egert

et al. 2020

Nutrients

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Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observational data only for the risk of ARI. No respective RCTs are available for the prevention of chronic obstructive pulmonary disease (COPD), MS, and T1DM. SRs of RCTs indicate beneficial therapeutic effects in vitamin D-deficient patients with asthma and COPD, while effects on major depression and T1DM need to be further elucidated. Mendelian randomisation studies do not consistently support the results of SRs. Since several limitations of the included SRs and existing RCTs do not permit definitive conclusions regarding vitamin D and the selected diseases, further high-quality RCTs are warranted.

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Section: Primary Preventionsupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Primary Preventionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Maretzke¹,

Bechthold²,

Egert

et al. 2020

Nutrients

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“…A recent systematic review by Fried et al. and a meta‐analysis by Beckhaus et al. concluded that higher maternal intake of vitamin D was associated with lower risk of offspring wheeze; however, no associations were found for other allergy outcomes.…”

Section: Individual Immunomodulatory Nutrient Intakementioning

confidence: 99%

Maternal dietary intake in pregnancy and lactation and allergic disease outcomes in offspring

Venter

Brown

Maslin

et al. 2017

Pediatric Allergy Immunology

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As the prevalence of allergic disease dramatically rises worldwide, prevention strategies are increasingly being considered. Given the potential modulatory effect of nutritional factors on disease, altering maternal diet during pregnancy and/or lactation has been considered in preventing allergic disease in offspring. Although there are a number of observational studies that have examined possible associations between maternal diet and allergic outcomes in offspring, interventional trials are limited. Furthermore, there is a paucity of studies that have prospectively studied maternal dietary intake as well as measuring maternal and infant biologic samples (blood, urine, breast milk) and their relation to allergic outcomes in infants. There is also a particular need to define terminology such as 'fruit and vegetables intake', 'healthy diet', and 'diet diversity' in order to make studies comparable. In this review, we discuss current evidence of maternal dietary factors during pregnancy and/or lactation that may play a role in the offspring developing allergic disease, including factors such as overall dietary intake patterns, specific whole food consumption (fish, fruit and vegetables, and common allergic foods), and individual immunomodulatory nutrient intakes. Additionally, we discuss the limitations of previous studies and propose improvements to study design for future investigation.Abbreviations CI, confidence interval; EPA, eicosapentaenoic acid; FFQ, food frequency questionnaire; HMOS, human milk oligosaccharides; Ig, immunoglobulin; n-3PUFA, omega-3 polyunsaturated fatty acids; NCD, non-communicable disease; RCT, randomized controlled trial; RR, relative risk; SCFA, short-chain fatty acids; UV, ultra violet; WAO, World Allergy Organization.

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“…Vitamin 25(OH)D deficiency results primarily from unawareness that moderate sun exposure constitutes the principal source of vitamin D3 in most humans [2]. The active form of vitamin D, i.e., 1,25(OH) 2 D, is now recognized as an important hormone playing a crucial role in skeletal homeostasis (classical effects) and exerting non-classical effects in various pathological and physiological conditions, such as cancer, arterial hypertension, cardiovascular diseases, brain development and immunomodulation [3,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Serum 25(OH) Vitamin D Levels in Polish Women during Pregnancies Complicated by Hypertensive Disorders and Gestational Diabetes

Domaracki

Sadłecki

Odrowąż-Sypniewska

et al. 2016

IJMS

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Background: An association between the level of vitamin D and the risk of pregnancy-related complications remains unclear. The aim of this study was to examine concentrations of 25(OH) vitamin D in Polish women with normal pregnancies and pregnancies complicated by gestational hypertension, preeclampsia or gestational diabetes mellitus (GDM). Moreover, we analyzed an association between maternal serum 25(OH)D and the risk of gestational hypertension, preeclampsia and GDM. Material and Methods: The study included 207 pregnant women, among them 171 with pregnancy-related complications: gestational hypertension (n = 45), preeclampsia (n = 23) or GDM (n = 103). The control group consisted of 36 women with normal pregnancies. Concentrations of serum 25(OH)D were measured at admission to the hospital prior to delivery Results: Patients with hypertension did not differ significantly from the controls in terms of their serum 25(OH)D concentrations (18.20 vs. 22.10 ng/mL, p = 0.15). Highly significant differences were found in 25(OH)D concentrations of women with preeclampsia and the controls (14.75 vs. 22.10 ng/mL, p = 0.0021). GDM was not associated with significant differences in 25(OH)D concentration. A low level of 25(OH)D turned out to be associated with an increased risk of preeclampsia during pregnancy on both univariate and multivariate regression analysis, and was a significant predictor of this condition on ROC (receiver operating characteristic) analysis (AUC = 0.70, p < 0.01). Conclusions: 25(OH)D deficiency is common among pregnant Polish women. Low concentrations of 25(OH)D may play a role in the etiopathogenesis of preeclampsia. Routine assessment of the 25(OH)D level during pregnancy may be crucial for the identification of women at increased risk of preeclampsia.

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Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review

Cited by 15 publications

References 82 publications

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Maternal dietary intake in pregnancy and lactation and allergic disease outcomes in offspring

Serum 25(OH) Vitamin D Levels in Polish Women during Pregnancies Complicated by Hypertensive Disorders and Gestational Diabetes

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