Maternal and congenital cytomegalovirus infections in a population‐based pregnancy cohort study

Abstract

CMV is the most common cause of congenital infection. During the past few decades, there has been a change in behaviour that possibly has affected the CMV infection rate of mother and child. We investigated 1350 randomly selected pregnant women from the Norwegian Mother and Child Cohort Study using an algorithm for detection of maternal and congenital CMV (cCMV) infection including both serology and nucleic acid amplification assay. The CMV IgG seroprevalence was 54% and 23 (3.7%) mothers seroconverted. Three (0.22%) children had a positive CMV PCR in the umbilical cord blood. The transmission rate was lower than reported in previous studies, probably due to lower sensitivity in plasma compared to saliva and urine. The prevalence of cCMV in the present study was compared with the number registered with the ICD‐10 code P.35.1‐congenital CMV infection in the Norwegian Patient Register. The number registered was lower than the number of estimated infections. Factors like lower level of education and parity were associated with higher CMV IgG seroprevalence, but no significant difference could be linked to age. In conclusion, in this cohort of pregnant women, a high CMV IgG seroconversion rate was found, while the vertical transmission rate was low.

Seroepidemiology Study of Cytomegalovirus and Rubella in Pregnant Women in Luanda, Angola: Geospatial Distribution and its Association with Socio-Demographic and Clinical-Obstetric Determinants

“…Moreover, our data were also similar with results report in other world countries with values between 92.6% and 100%: Iran [22], Palestine [23], China [24], Brazil [25], Turkey [26], Nigeria [27] and Cuba [28]. In contrast, our prevalence was higher than that reported in developed countries: 42.3% in Germany [29], 46.8% in France, 49% in the United Kingdom [30], 54% in Norway [31], 56.3% in Finland [32], 58.7% in France [33], 65.9% in Italy [34], 66% in Japan [35], 62.4% in Poland [12] and 70.0% in the United States [36].…”

Risk for the occupational infection by cytomegalovirus among health-care workers

“…Moreover, we demonstrated that the annual CMV seroconversion rates after BBFE were also approximately 3%, which was statistically not different from those with natural courses. The annual CMV seroconversion rates observed in this study were consistent with previous data obtained from pregnant women: 2.1% (24/1122) between first and third trimesters [8], 3.7% (23/621) between gestational week 17 and birth [9], and average of 2.3% in pregnancy period [10]. These results might suggest the rarity of CMV infection through the exposure events in healthcare settings.…”

Prevalence of herpes -, measles morbillivirus-, parvovirus B19 - and rubella viruses immunoglobulin G among women with chronic hepatitis B of reproductive age in Denmark: A cross-sectional study

“…This difference in seroprevalence remained when stratifying by age, region of origin, or year of blood sampling. A 2017 study from Norway also showed a seroprevalence of antibodies against CMV among pregnant women to be lower (54%) than what is found in our study population of mainly immigrant background (Barlinn et al 2018). A 2014 metanalysis investigating the prevalence of congenital CMV infection found that the maternal prevalence of antibodies against CMV in Africa and Asia ranged from 90% to 100%, in line with our observations (Lanzieri et al 2014).…”