Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects

Zhu, Yeyi; Zhang, Cuilin; Liu, Danping; Grantz, Katherine L.; Wallace, Maeve; Mendola, Pauline

doi:10.1016/j.envres.2015.06.002

Cited by 55 publications

(38 citation statements)

References 38 publications

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“…For the range of PM 2.5 concentrations considered in this study, the risk of having a baby with CP was estimated to increase by 43%, for every 10 μg/m 3 increase in county-level PM 2.5 concentration. These findings agree with another recent study (Zhu et al, 2015) that used data from 19 hospitals across the United States during a similar time period. Note that the Zhu et al study also used the CMAQ model to estimate exposure, which is one of two inputs used in the downscaling fusion model in our current study.…”

Section: Discussionsupporting

confidence: 93%

“…First, it has a large sample size of about 4.7 million total births and 7,000 orofacial cleft cases from four states in the United States. This is about three times the number of cases included in a study in Florida (Tanner, 2015) and at least an order of magnitude more cases than other previous analyses on this topic (Hwang and Jaakkola, 2008;Hansen, 2009;Ritz, 2002;Gilboa, 2005;Marshall et al, 2010;Zhu, 2015). In addition, except for one study (Zhu et al, 2015), previous studies in the United States used monitoring data to estimate air pollution exposure, although the spatial and temporal coverage of air pollution monitoring stations are limited.…”

Section: Discussionmentioning

confidence: 91%

“…This is about three times the number of cases included in a study in Florida (Tanner, 2015) and at least an order of magnitude more cases than other previous analyses on this topic (Hwang and Jaakkola, 2008;Hansen, 2009;Ritz, 2002;Gilboa, 2005;Marshall et al, 2010;Zhu, 2015). In addition, except for one study (Zhu et al, 2015), previous studies in the United States used monitoring data to estimate air pollution exposure, although the spatial and temporal coverage of air pollution monitoring stations are limited. In our study, a Bayesian downscaler fusion model, which had both monitoring and modeling data as inputs, was used to estimate daily PM 2.5 and ozone concentration data ((Berrocal et al, 2012)) for the entire contiguous United States; this model has been shown to have better performance compared with other fusion models.…”

Section: Discussionmentioning

confidence: 91%

“…Also, several U.S. studies (in California, Texas, New Jersey, and Florida) reported no association between the criteria air pollutants evaluated and orofacial clefts (Ritz et al, 2002;Gilboa et al, 2005;Marshall et al, 2010;Tanner et al, 2015;Padula et al, 2013). Recently, a study covering multiple regions in the United States found that exposure to several criteria air pollutants during preconception and early gestation was associated with elevated odds for CP, while CL+/-CP was only associated with preconceptional SO 2 exposure (Zhu et al, 2015). Two recent meta-analyses concluded that there was no association between ambient air pollution and risk of orofacial clefts (Vrijheid et al, 2011;Chen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Maternal exposure to ozone and PM2.5 and the prevalence of orofacial clefts in four U.S. states

Zhou*¹,

Gilboa²,

Herdt³

et al. 2016

ISEE Conference Abstracts

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Background-While there is some evidence that maternal exposure to ambient air pollution is associated with orofacial clefts in offspring, the epidemiologic studies have been largely equivocal. We evaluated whether maternal exposure to elevated county-level ambient fine particulate matter with aerodynamic diameter ≤2.5 μm (PM 2.5 ) and ozone during early gestation was associated with a higher prevalence of orofacial clefts. * Corresponding author. yzhou2@cdc.gov (Y. Zhou). New York City), and Texas. The air pollution exposure assessment for gestational weeks 5-10 was based on county-level average concentrations of PM 2.5 and ozone data generated using a Bayesian fusion model available through CDC's Environmental Public Health Tracking Network. Two outcomes were analyzed separately: cleft lip with or without cleft palate, cleft palate alone. In logistic regression analyses, we adjusted for factors that were suspected confounders or modifiers of the association between the prevalence of orofacial clefts and air pollution, i.e., infant sex, race-ethnicity, maternal education, smoking status during pregnancy, whether this was mother's first baby, maternal age.Results-Each 10 μg/m 3 increase in PM 2.5 concentration was significantly associated with cleft palate alone (OR =1.43, 95% CI: 1.11-1.86). There was no significant association between PM 2.5 concentration and cleft lip with or without cleft palate. No associations were observed between ozone exposure and the two outcomes of orofacial clefts.Conclusions-Our study suggests that PM 2.5 significantly increased the risk of cleft palate alone, but did not change the incidence of cleft lip with or without palate. Ozone levels did not correlate with incidence of orofacial clefts.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal exposure to ozone and PM2.5 and the prevalence of orofacial clefts in four U.S. states

Zhou*¹,

Gilboa²,

Herdt³

et al. 2016

ISEE Conference Abstracts

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“…In addition to the effect for CO mentioned above, we also observed an effect for NO x that is consistent with this notion but for the other criteria pollutants the preconception window risks were null or inverse. Chronic effects of air pollution are well known with respect to respiratory and cardiac effects ( 38), including increased mortality (39), and we have also observed a chronic effect of preconception exposure on other pregnancy outcomes (40;41). Collectively, these findings suggest further investigation of chronic preconception air pollutant exposure on pregnancy outcomes is warranted.…”

Section: Discussionsupporting

confidence: 57%

Preterm birth and air pollution: Critical windows of exposure for women with asthma

Mendola

Wallace

Hwang

et al. 2016

Journal of Allergy and Clinical Immunology

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Background Ambient air pollutants may increase preterm birth (PTB) risk but critical exposure windows are uncertain. The interaction of asthma and pollutant exposure is rarely studied. Objective To assess the interaction of maternal asthma and air pollutant exposures in relation to PTB risk. Methods Electronic medical records for 223,502 U.S. deliveries were linked with modified Community Multiscale Air Quality model outputs. Logistic regression with generalized estimating equations estimated the odds ratio (OR) and 95% confidence intervals (CI) for PTB based on the interaction of maternal asthma and particulate matter <2.5 microns (PM2.5) and <10 microns (PM10), ozone (O3), nitrogen oxides (NOx), sulfur dioxide (SO2) and carbon monoxide (CO) per interquartile range. For each gestational week 23–36, exposures among women who delivered were compared to those remaining pregnant. Three-months preconception, whole pregnancy, weeks 1–28 and the last six weeks of gestation averages were also evaluated. Results Assessing PTB by gestational week, significant asthma interactions were sporadic before 30 weeks but more common during weeks 34–36 with higher risk among asthmatic mothers for NOx, CO and SO2 exposure and an inverse association with O3 in week 34. Odds of PTB were significantly higher among asthmatics for CO and NOx preconception and early in pregnancy. In the last six weeks of pregnancy, PM10 risk for PTB was higher among asthmatics. Conclusion Asthmatic mothers may experience higher risk for PTB after exposure to traffic-related pollutants such as CO and NOx particularly for exposures three-months preconception and in the early weeks of pregnancy.

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Associations between cumulative environmental quality and ten selected birth defects in Texas

Krajewski

Rappazzo

Langlois

et al. 2020

Birth Defects Research

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BackgroundCauses of most birth defects are largely unknown. Genetics, maternal factors (e.g., age, smoking) and environmental exposures have all been linked to some birth defects, including neural tube, oral cleft, limb reduction, and gastroschisis; however, the contribution of cumulative exposures across several environmental domains in association with these defects is not well understood.MethodsThe Environmental Quality Index (EQI) and its domains (air, water, land, sociodemographic, built) were used to estimate county‐level cumulative environmental exposures from 2006–2010 and matched to birth defects identified from Texas Birth Defects Registry and live birth records from births in years 2007–2010 (N = 1,610,709). Poisson regression models estimated prevalence ratios (PR) and 95% confidence intervals (CI) for associations between 10 birth defects and the EQI.ResultsWe observed some positive associations between worst environmental quality and neural tube, anencephaly, spina bifida, oral cleft, cleft palate, cleft lip with and without cleft palate, and gastroschisis [PR range: 1.12–1.55], but near null associations with limb reduction defects. Among domain specific results, we observed the strongest positive associations with the sociodemographic domain across birth defects but varied positive associations among the air and water domains, and negative or null associations with the land and built domains. Overall, few exposure‐response patterns were evident.ConclusionsOur results highlight the complexities of cumulative, simultaneous environmental exposures in the prevalence rates of 10 selected birth defects. We were able to explore the impact of overall and domain specific environmental quality on birth defects and identify potential domain specific drivers of these associations.

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Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects

Cited by 55 publications

References 38 publications

Maternal exposure to ozone and PM2.5 and the prevalence of orofacial clefts in four U.S. states

Maternal exposure to ozone and PM2.5 and the prevalence of orofacial clefts in four U.S. states

Preterm birth and air pollution: Critical windows of exposure for women with asthma

Associations between cumulative environmental quality and ten selected birth defects in Texas

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