Maternal alcohol use and medically indicated vs. spontaneous preterm birth outcomes: a population-based study

Aliyu, Muktar H.; Lynch, O’Neil; Belogolovkin, Victoria; Zoorob, Roger; Salihu, Hamisu M.

doi:10.1093/eurpub/ckq036

Cited by 23 publications

(29 citation statements)

References 30 publications

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“…Some baseline characteristics varied significantly between the countries, highlighting the diversity of the HIV-infected pregnant population and resource availability in sub-Saharan Africa. Whereas the higher risk of PTD in Zambia may be attributable to differences in maternal characteristics, such as higher parity [17], higher prevalence of syphilis [18], and higher rate of alcohol use [19], the disparity between the settings may also contribute. Syphilis and hemoglobin screening were often not done in Zambia.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes and birth defects from an antiretroviral drug safety study of women in South Africa and Zambia

Liu

Farahani

Mashamba

et al. 2014

Aids

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Objective To evaluate the safety of combination antiretroviral therapy (ART) in conception and pregnancy in different health systems. Design A pilot ART registry to measure the prevalence of birth defects and adverse pregnancy outcomes in South Africa and Zambia. Methods HIV-infected pregnant women on ART prior to conception were enrolled until delivery, and their infants were followed until 1 year old. Results Between October 2010 and April 2011, 600 women were enrolled. The median CD4+ cell count at study enrollment was lower in South Africa than Zambia (320 vs. 430 cells/μl; P < 0.01). The most common antiretroviral drugs at the time of conception included stavudine, lamivudine, and nevirapine. There were 16 abortions (2.7%), one ectopic pregnancy (0.2%), 12 (2.0%) stillbirths, and 571 (95.2%) live infants. Deliveries were more often preterm (29.7 vs. 18.4%; P = 0.01) and the infants had lower birth weights (2900 vs. 2995 g; P = 0.11) in Zambia compared to South Africa. Thirty-six infants had birth defects: 13 major and 23 minor. There were more major anomalies detected in South Africa and more minor ones in Zambia. No neonatal deaths were attributed to congenital birth defects. Conclusions An Africa-specific, multi-site antiretroviral drug safety registry for pregnant women is feasible. Different prevalence for preterm delivery, delivery mode, and birth defect types between women on preconception ART in South Africa and Zambia highlight the potential impact of health systems on pregnancy outcomes. As countries establish ART drug safety registries, documenting health facility limitations may be as essential as the specific ART details.

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Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes and birth defects from an antiretroviral drug safety study of women in South Africa and Zambia

Liu

Farahani

Mashamba

et al. 2014

Aids

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“…It should be noted, however, that no studies conducted in Asian countries were included in this meta-analysis [2]. Four studies in the USA have shown significant positive relationships between low to moderate maternal alcohol consumption during pregnancy and the risk of LBW, PTB, and/or SGA [3-6], while equally significant inverse associations have been observed in two studies in Canada and Spain [7,8]. To our knowledge, there have been only three previous studies on alcohol consumption during pregnancy and birth weight or LBW in Japan, none of which have revealed any associations [9-11]; however, no epidemiological studies in Japan have examined the association of maternal alcohol consumption during pregnancy with the risk of PTB and SGA.…”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study

Miyake

Tanaka

Okubo

et al. 2014

BMC Pregnancy Childbirth

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BackgroundA recent meta-analysis showed no relationships between light to moderate alcohol consumption during pregnancy and the risk of low birth weight (LBW), preterm birth (PTB), or small-for-gestational-age (SGA). Here, we present the first epidemiological study on this topic in Japan.MethodsStudy subjects were 1565 Japanese mothers with singleton pregnancies and the babies born from these pregnancies. Alcohol consumption during pregnancy was assessed using a self-administered diet history questionnaire. Alcohol consumption during pregnancy was classified into three categories (none, < 1 g/day, and ≥ 1 g/day).ResultsThe mean birth weight of the babies was 3006.3 g. 7.7% were classified as LBW, 4.0% as PTB, and 7.8% as SGA. The range of maternal alcohol consumption during pregnancy was 0.0 to 11.7 g per day: 1356 (86.7%) mothers were abstainers and the 95th percentile value was 0.84 g per day. Compared with abstinence, alcohol consumption of 1.0 g or more per day during pregnancy was significantly associated with an increased risk of PTB with a significant positive linear trend: the adjusted OR for PTB associated with maternal alcohol consumption of 1.0 g or more per day was 2.58 (95% CI: 1.004 - 5.80, P for trend = 0.03). No significant relationships were observed between maternal alcohol consumption during pregnancy and the risk of LBW or SGA, and there was no material association between maternal alcohol consumption during pregnancy and birth weight.ConclusionsThis is the first study in Japan to show that maternal alcohol consumption during pregnancy of 1.0 g or more per day was significantly positively associated with the risk of PTB, but not LBW or SGA.

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“…For multiple linkages, the most likely potential linkage was based on the weighted score and quality of agreement indicator. The methods and algorithm used in linking vital records information into sibling relationships and the process of validation have been described in detail previously [31,32]. …”

Section: Methodsmentioning

confidence: 99%

“…The Missouri vital record system is a reliable one that has been used as the gold standard to validate U.S. national datasets that involve matching and linking procedures [32,33]. The Missouri maternally linked cohort dataset contains information on both live births and fetal deaths for each sibling and provides a platform for a longitudinal study of birth outcomes for a given cohort of mothers.…”

Section: Methodsmentioning

confidence: 99%

Small size for gestational age and the risk for infant mortality in the subsequent pregnancy

Salihu

Salinas

August

et al. 2012

Annals of Epidemiology

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Purpose To examine the association between small for gestational age (SGA) in the first pregnancy and risk for infant mortality in the second pregnancy. Methods This is a population-based, retrospective cohort study in which we used the Missouri maternally linked cohort dataset for 1978–2005. Analyses were restricted to women who had two singleton pregnancies during the study period. The exposure was SGA in the first pregnancy, whereas the primary outcome was infant mortality in the second pregnancy. Kaplan-Meier Estimate and Cox proportional hazard regression were conducted. Results Infant mortality was significantly greater among mothers with previous SGA (P < .01). A persistent association of previous SGA with subsequent infant mortality was observed (adjusted hazard ratio [AHR] 1.35, 95% confidence interval [95% CI] 1.24–1.48). Race-specific data illustrated that black women with a previous SGA birth were 40% more likely to experience infant mortality (AHR 1.40, 95% CI 1.21–1.63) than their counterparts without a history of SGA, but white women with a previous SGA had an increased risk of 31% (AHR 1.31, 95% CI 1.17–1.46). Conclusions Women with previous SGA bear increased risks for subsequent infant mortality, which was greater among black mothers. Hence, SGA plays an important role in the black–white disparity in infant mortality. Women’s previous childbearing experiences could serve as important criterion in determining appropriate interconception strategies to improve infant health and survival.

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Maternal alcohol use and medically indicated vs. spontaneous preterm birth outcomes: a population-based study

Cited by 23 publications

References 30 publications

Pregnancy outcomes and birth defects from an antiretroviral drug safety study of women in South Africa and Zambia

Pregnancy outcomes and birth defects from an antiretroviral drug safety study of women in South Africa and Zambia

Alcohol consumption during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study

Small size for gestational age and the risk for infant mortality in the subsequent pregnancy

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